HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	24189400, 16729043, 22973453, 16273093
Identification Methods	affinity chromatography technology, pull down, unspecified method, protein array, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1342
+	Hs
		601964 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		129152 P85B_HUMAN (1-728): 0: 549: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338776 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (696-1307): 1.8e-127: 435: 22.51
+	Hs
		129278 P85B_HUMAN (1-728): 0: 549: 100.00		ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13
+	Hs
		129282 P85B_HUMAN (1-728): 0: 549: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51
+	Hs
		111148 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19