HitPredict

Interactor 1: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Interactor 2: INCE (Q9NQS7)
Inner centromere protein
Gene: INCENP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 19951914, 18773538, 11050385, 16239925, 12925766, 20562864, 17956729, 16571674, 15316025, 15249581, 29568061, 31586073, 33961781, 35271311, 32707033, 36736316, 19995937, 21554500, 18477699, 19357306 and 5 others

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Identification Methods affinity chromatography technology, pull down, proximity labelling technology, two hybrid, protein kinase assay, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains INCENP_ARK-bind~Pkinase
Common GO terms GO:0000278 - mitotic cell cycle
GO:0000281 - mitotic cytokinesis
GO:0000776 - kinetochore
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 12 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024