Protein: PRS4
26S proteasome regulatory subunit 4 (P26s4)

Gene: PRS4, Rpt2
Organism: Drosophila melanogaster
Interactions: 132
UniProt ID: P48601

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005838 - proteasome regulatory particle
GO:0008540 - proteasome regulatory particle, base subcomplex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

821820

PSA2
Proteasome subunit alpha type-2

4

20

High-throughput

0.866

High

875039

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

4

20

High-throughput

0.866

High

198032

PRS8
26S proteasome regulatory subunit 8

3

18

High-throughput

0.812

High

556649

PSA1
Proteasome subunit alpha type-1

3

20

High-throughput

0.812

High

874974

Q7KMQ0
26S proteasome regulatory subunit 7

3

19

High-throughput

0.812

High

875020

Q9VJJ0
Proteasome subunit beta

3

20

High-throughput

0.812

High

875054

Q9W414
Regulatory particle triple-A ATPase 4

3

19

High-throughput

0.812

High

47754

A0AQH0
Proteasome subunit beta

2

20

High-throughput

0.737

High

611471

PSA4
Proteasome subunit alpha type-4

2

20

High-throughput

0.737

High

652730

PSA71
Proteasome subunit alpha type-7-1

2

20

High-throughput

0.737

High

684544

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

20

High-throughput

0.737

High

822036

PSB1
Proteasome subunit beta type-1

2

20

High-throughput

0.737

High

874969

Q7K148
Proteasome subunit beta

2

20

High-throughput

0.737

High

874988

PSA5
Proteasome subunit alpha type-5

2

20

High-throughput

0.737

High

874994

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

20

High-throughput

0.737

High

874995

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

20

High-throughput

0.737

High

874997

Q9V3V6
26S proteasome regulatory complex subunit p50

2

20

High-throughput

0.737

High

874998

Q9V405
26S proteasome regulatory subunit 6B

2

17

High-throughput

0.737

High

875002

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.737

High

875025

PSB4
Proteasome subunit beta type-4

2

20

High-throughput

0.737

High

875036

Q9VUJ1
Proteasome subunit beta

2

20

High-throughput

0.737

High

875056

PSB3
Proteasome subunit beta type-3

2

20

High-throughput

0.737

High

875040

Q9VWD9
Ubiquilin-like protein

1

20

Small-scale

0.647

High

875057

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

874976

TERA
Transitional endoplasmic reticulum ATPase TER94

1

11

High-throughput

0.590

High

874983

Q8IRD1
AAA+ ATPase domain-containing protein

1

13

High-throughput

0.590

High

875008

Q9VCD5
UV excision repair protein RAD23

1

20

High-throughput

0.590

High

875021

Q9VK14
Proteasome subunit alpha type

1

20

High-throughput

0.590

High

875034

Q9VTQ9
AT06668p

1

19

High-throughput

0.590

High

875046

PSMD5
26S proteasome non-ATPase regulatory subunit 5

3

9

Small-scale

0.590

High

875013

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

10

High-throughput

0.587

High

875010

ATD3A
ATPase family AAA domain-containing protein 3A homolog

1

20

High-throughput

0.575

High

669685

PSMD3
Probable 26S proteasome non-ATPase regulatory subunit 3

2

14

High-throughput

0.571

High

874963

ROP
Protein ROP

2

6

High-throughput

0.571

High

874970

ADRM1
Proteasomal ubiquitin receptor ADRM1 homolog

2

11

High-throughput

0.571

High

874971

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

20

High-throughput

0.571

High

874973

Q7KMP8
26S proteasome non-ATPase regulatory subunit 13

2

14

High-throughput

0.571

High

874986

Q8T8W3
AT21416p

2

5

High-throughput

0.571

High

874996

PSMD1
26S proteasome non-ATPase regulatory subunit 1

2

20

High-throughput

0.571

High

875001

Q9V470
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

2

9

High-throughput

0.571

High

875045

Q9VXQ5
Chaperonin containing TCP1 subunit 6

2

7

High-throughput

0.571

High

874993

CSN4
COP9 signalosome complex subunit 4

1

20

High-throughput

0.528

High

355920

O96692
small monomeric GTPase

2

10

High-throughput

0.521

High

360525

COX2
Cytochrome c oxidase subunit 2

2

5

High-throughput

0.521

High

715080

CLH
Clathrin heavy chain

2

4

High-throughput

0.521

High

874978

Q7KN94
Electron transfer flavoprotein subunit alpha

2

5

High-throughput

0.521

High

875038

Q9VV75
AT02348p

2

4

High-throughput

0.521

High

874956

ACT3
Actin-57B

1

2

High-throughput

0.508

High

875015

Q9VGU4
FI02822p

1

10

High-throughput

0.489

High

874966

SIMA
Protein similar

1

9

High-throughput

0.479

High

874975

Q7KMQ6
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.479

High

874980

AKT1
RAC serine/threonine-protein kinase

1

7

High-throughput

0.479

High

874990

FOXO
Forkhead box protein O

1

1

High-throughput

0.479

High

875009

Q9VEC2
Proteasome assembly chaperone 2

1

6

High-throughput

0.479

High

875018

Q9VIJ5
GEO05038p1

1

5

High-throughput

0.479

High

875048

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

14

High-throughput

0.479

High

875026

Q9VNE0
PHD and RING finger domain-containing protein 1

1

2

High-throughput

0.464

High

432179

MYSA
Myosin heavy chain, muscle

1

1

High-throughput

0.457

High

660428

CDK2
Cyclin-dependent kinase 2

1

5

High-throughput

0.457

High

661920

PP2A
Serine/threonine-protein phosphatase PP2A

1

2

High-throughput

0.457

High

874957

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

16

High-throughput

0.457

High

874959

JNK
Stress-activated protein kinase JNK

1

6

High-throughput

0.457

High

874961

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.457

High

874979

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

1

High-throughput

0.457

High

564957

ATNA
Sodium/potassium-transporting ATPase subunit alpha

1

10

High-throughput

0.445

High

726316

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.445

High

782695

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

5

High-throughput

0.445

High

834834

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

3

High-throughput

0.445

High

852922

ACTZ
Actin-related protein 1

1

7

High-throughput

0.445

High

874955

TCPG
T-complex protein 1 subunit gamma

1

13

High-throughput

0.445

High

874964

Q0E9E2
Pyruvate carboxylase

1

6

High-throughput

0.445

High

874984

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.445

High

874985

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.445

High

874987

LDH
L-lactate dehydrogenase

1

6

High-throughput

0.445

High

874999

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.445

High

875000

Q9V455
Importin subunit alpha

1

5

High-throughput

0.445

High

875003

Q9V9Q4
LD43819p

1

5

High-throughput

0.445

High

875014

IPO9
Importin-9

1

6

High-throughput

0.445

High

875016

Q9VHL2
T-complex protein 1 subunit eta

1

8

High-throughput

0.445

High

875022

Q9VK69
T-complex protein 1 subunit delta

1

6

High-throughput

0.445

High

875023

NFS1
Cysteine desulfurase, mitochondrial

1

5

High-throughput

0.445

High

875028

Q9VQI5
Interferon-related developmental regulator 1

1

4

High-throughput

0.445

High

875031

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

4

High-throughput

0.445

High

875052

Q9W392
T-complex protein 1 subunit beta

1

13

High-throughput

0.445

High

118685

M9NF85
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

874992

Q9N6D8
GH11591p

1

3

High-throughput

0.439

High

875058

X2JCD3
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

52646

A1Z729
NADP-retinol dehydrogenase

1

13

High-throughput

0.437

High

874958

CCD1P
Probable cytochrome P450 12d1 proximal, mitochondrial

1

5

High-throughput

0.437

High

874968

Q76NQ0
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

10

High-throughput

0.437

High

875011

RS5B
Small ribosomal subunit protein uS7B

1

2

Small-scale

0.437

High

875027

Q9VNI4
Proteasome assembly chaperone 1

1

5

High-throughput

0.437

High

875043

Q9VWL0
Mec2

1

6

High-throughput

0.437

High

853006

ARP6
Actin-related protein 6

1

5

High-throughput

0.417

High

874982

Q8IQG0
Uncharacterized protein, isoform A

1

1

High-throughput

0.417

High

875035

Q9VU13
LD45603p

1

1

High-throughput

0.417

High

144860

ATPG
ATP synthase subunit gamma, mitochondrial

1

5

High-throughput

0.407

High

304189

ERD2
ER lumen protein-retaining receptor

1

4

High-throughput

0.407

High

756728

FAS2
Fasciclin-2

1

2

High-throughput

0.407

High

829628

ARF4
ADP ribosylation factor 4

1

6

High-throughput

0.407

High

852164

COPB
Coatomer subunit beta

1

5

High-throughput

0.407

High

874962

ARL2
ADP-ribosylation factor-like protein 2

1

12

High-throughput

0.407

High

874965

Q0KIB3
Histone acetyltransferase type B catalytic subunit

1

5

High-throughput

0.407

High

874967

Q6NP35
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

10

High-throughput

0.407

High

874972

Q7KLX3
Translocon-associated protein subunit delta

1

2

High-throughput

0.407

High

874977

Q7KN75
Dodeca-satellite-binding protein 1, isoform A

1

6

High-throughput

0.407

High

874981

Q8IPU8
BNIP3, isoform B

1

3

High-throughput

0.407

High

874991

Q960C7
NADP-retinol dehydrogenase

1

13

High-throughput

0.407

High

875005

Q9VAL7
Calnexin 99A, isoform A

1

3

High-throughput

0.407

High

875007

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

5

High-throughput

0.407

High

875017

ARL8
ADP-ribosylation factor-like protein 8

1

6

High-throughput

0.407

High

875019

Q9VJD1
Glucosidase 2 subunit beta

1

4

High-throughput

0.407

High

875029

Q9VQL7
Fatty acid synthase

1

3

High-throughput

0.407

High

875032

SRP68
Signal recognition particle subunit SRP68

1

5

High-throughput

0.407

High

875037

Q9VV51
1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform A

1

6

High-throughput

0.407

High

875041

RS10B
Small ribosomal subunit protein eS10B

1

7

High-throughput

0.407

High

875042

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

6

High-throughput

0.407

High

875044

Q9VXG0
Cell division cycle 50, isoform A

1

5

High-throughput

0.407

High

875047

Q9W0E4
Aminopeptidase

1

6

High-throughput

0.407

High

875050

Q9W1H8
acetyl-CoA C-acyltransferase

1

3

High-throughput

0.407

High

875051

Q9W335
Translocon-associated protein subunit alpha

1

1

High-throughput

0.407

High

875053

Q9W3N1
RH59310p

1

4

High-throughput

0.407

High

875055

Q9W4N8
LD30122p

1

3

High-throughput

0.407

High

874960

HLES
Protein hairless

2

0

Small-scale

0.323

High

875033

Q9VTL6
DNA-directed RNA polymerase III subunit RPC8

2

0

High-throughput

0.310

High

875049

Q9W139
GH14476p

1

0

High-throughput

0.251

Low

874989

Q95RF6
LD34461p

1

0

High-throughput

0.249

Low

875024

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

875030

MELT
Protein melted

1

0

High-throughput

0.249

Low

875012

Q9VFL8
FI01135p

1

0

High-throughput

0.238

Low

875004

FRIL
Ferritin light chain

1

0

High-throughput

0.232

Low

875006

CISD2
CDGSH iron-sulfur domain protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025