HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019903 - protein phosphatase binding GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 770
+	Hs
		776765 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		729741 BTK_MOUSE (529-727): 3.53e-31: 132: 19.25		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		776597 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		412065 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776660 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		411624 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		442788 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		433628 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		454804 FGR_HUMAN (556-728): 2.44e-29: 125: 22.10		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		403422 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		522829 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776611 BLK_HUMAN (556-724): 7.19e-29: 123: 22.16		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776617 BMX_HUMAN (541-726): 1.9e-24: 110: 19.69		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		655247 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		849903 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		522836 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		337403 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786602 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		337381 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Dm
		1096410 Q7JVF1_DROME (312-474): 4.32e-15: 79.1: 23.56		STAT_DROME (1-755): 0: 648: 22.58