HitPredict

Interactor 1: RN185 (Q96GF1)
E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)
Gene: RNF185

Interactor 2: UBQL4 (Q9NRR5)
Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)
Gene: UBQLN4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17558393
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006914 - autophagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 601
+	Xl
		1140144 Q5XGX4_XENLA (1-192): 1.06e-55: 176: 91.15		Q801P8_XENLA (2-601): 7.53e-137: 413: 71.33
+	Hs
		1292364 RN185_HUMAN (1-192): 2.35e-56: 178: 100.00		UBQL1_HUMAN (11-601): 1.16e-127: 389: 59.16
+	Xl
		1140127 Q5XGX4_XENLA (1-192): 1.06e-55: 176: 91.15		Q6DCM1_XENLA (12-601): 1.46e-124: 380: 60.14
+	Hs
		1292361 RN185_HUMAN (1-192): 2.35e-56: 178: 100.00		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		1019380 TRI26_HUMAN (26-132): 1.42e-27: 109: 23.48		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		1295780 RN170_HUMAN (26-191): 1.11e-28: 109: 18.64		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		1318731 TRIM4_HUMAN (29-181): 3.24e-27: 108: 19.61		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		803715 RNF5_HUMAN (15-173): 2.18e-37: 129: 60.38		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		803694 TRI11_HUMAN (27-130): 9.09e-27: 107: 25.00		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		584896 RO52_HUMAN (26-144): 2e-26: 106: 20.17		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		803801 AMFR_HUMAN (27-171): 2.12e-24: 101: 19.18		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		872296 RN185_HUMAN (1-192): 2.35e-56: 178: 100.00		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Xl
		1140136 Q5XGX4_XENLA (1-192): 1.06e-55: 176: 91.15		Q7ZT10_XENLA (13-275): 3.77e-37: 144: 17.30
+	Xl
		1140133 Q5XGX4_XENLA (1-192): 1.06e-55: 176: 91.15		Q6GQF3_XENLA (13-103): 6.24e-34: 127: 28.26
+	Hs
		872220 TRI39_HUMAN (12-144): 3.88e-26: 106: 18.80		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Hs
		924117 RN185_HUMAN (1-192): 2.35e-56: 178: 100.00		RS27A_HUMAN (13-99): 1.11e-12: 68.1: 29.55
+	Hs
		872267 HLTF_HUMAN (1-129): 3.34e-24: 101: 20.93		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Xl
		1140130 Q5XGX4_XENLA (1-192): 1.06e-55: 176: 91.15		Q6GMC1_XENLA (13-99): 1.11e-12: 68.1: 29.55
+	Mm
		924253 RO52_MOUSE (21-142): 6.24e-28: 110: 16.39		RL40_MOUSE (13-103): 6.24e-34: 127: 28.26
+	Mm
		924236 RO52_MOUSE (21-142): 6.24e-28: 110: 16.39		RS27A_MOUSE (13-99): 1.13e-12: 68.1: 29.55