Protein: PKP1
Plakophilin-1 (Band 6 protein) (B6P)

Gene: PKP1
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q13835

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002159 - desmosome assembly
GO:0002160 - desmosome maintenance
GO:0003677 - DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036722

DSG1
Desmoglein-1

3

20

Small-scale

0.840

High

1117968

IKBD
NF-kappa-B inhibitor delta

2

10

High-throughput

0.783

High

1117985

CPLN2
Ciliogenesis and planar polarity effector 2

2

0

High-throughput

0.748

High

251341

CIDEA
Lipid transferase CIDEA

3

1

High-throughput

0.667

High

1117959

ARMC8
Armadillo repeat-containing protein 8

1

7

Small-scale

0.656

High

587654

DESP
Desmoplakin

2

17

Small-scale

0.634

High

1117962

CCD82
Coiled-coil domain-containing protein 82

2

1

High-throughput

0.628

High

1118010

FCF1
rRNA-processing protein FCF1 homolog

2

1

High-throughput

0.628

High

1118011

KIF3A
Kinesin-like protein KIF3A

2

6

High-throughput

0.628

High

371980

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.611

High

764226

CAH8
Carbonic anhydrase-related protein

2

4

High-throughput

0.611

High

1117943

SGO2
Shugoshin 2

2

1

High-throughput

0.611

High

1117976

TFG
Protein TFG

2

6

High-throughput

0.611

High

1117987

RBM24
RNA-binding protein 24

2

10

High-throughput

0.611

High

1117981

MITOK
Mitochondrial potassium channel

3

2

High-throughput

0.609

High

50136

BICL2
BICD family-like cargo adapter 2

2

16

High-throughput

0.606

High

1063236

GOGA2
Golgin subfamily A member 2

2

13

High-throughput

0.606

High

1117980

HOOK2
Protein Hook homolog 2

2

14

High-throughput

0.606

High

1117986

CAR10
Caspase recruitment domain-containing protein 10

2

11

High-throughput

0.606

High

474664

VIME
Vimentin

1

8

Small-scale

0.589

High

1064424

DSC1
Desmocollin-1

2

20

Small-scale

0.586

High

437164

K2C8
Keratin, type II cytoskeletal 8

1

4

Small-scale

0.586

High

269197

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1118006

FBXL4
F-box/LRR-repeat protein 4

2

3

High-throughput

0.574

High

1118004

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

3

Small-scale

0.573

High

1117949

TENS2
Tensin-2

1

8

High-throughput

0.573

High

521343

ARAF
Serine/threonine-protein kinase A-Raf

2

12

High-throughput

0.571

High

385101

K1C14
Keratin, type I cytoskeletal 14

1

8

Small-scale

0.561

High

255011

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.536

High

301803

ANXA9
Annexin A9

1

3

High-throughput

0.536

High

317173

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

9

High-throughput

0.536

High

370664

FOS
Protein c-Fos

1

6

High-throughput

0.536

High

436860

K1C18
Keratin, type I cytoskeletal 18

1

11

Small-scale

0.536

High

602784

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

733345

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

943047

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

1055597

GABPA
GA-binding protein alpha chain

1

4

High-throughput

0.536

High

1086581

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.536

High

1117946

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

6

High-throughput

0.536

High

1117951

JADE1
Protein Jade-1

1

5

High-throughput

0.536

High

1117953

OPN5
Opsin-5

1

6

High-throughput

0.536

High

1117954

CD109
CD109 antigen

1

4

High-throughput

0.536

High

1117955

FOXI2
Forkhead box protein I2

1

6

High-throughput

0.536

High

1117956

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.536

High

1117966

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.536

High

1117974

ZDH19
Palmitoyltransferase ZDHHC19

1

1

High-throughput

0.536

High

1117979

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

3

High-throughput

0.536

High

1117988

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

13

High-throughput

0.536

High

1117989

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

1117998

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1117999

RFOX1
RNA binding protein fox-1 homolog 1

1

10

High-throughput

0.536

High

1118000

GPT2L
G patch domain-containing protein 2-like

1

1

High-throughput

0.536

High

1118005

PHF11
PHD finger protein 11

1

9

High-throughput

0.536

High

1118007

OAZ3
Ornithine decarboxylase antizyme 3

1

2

High-throughput

0.536

High

1118009

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

194465

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

983653

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

1117961

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.513

High

1118001

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.513

High

1118008

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

1118012

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

Small-scale

0.501

High

1117940

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

229229

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

2

High-throughput

0.489

High

325316

OR2A4
Olfactory receptor 2A4

1

2

High-throughput

0.489

High

423905

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

866675

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.489

High

876323

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

1023771

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.489

High

1117942

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

1117957

MICU3
Calcium uptake protein 3, mitochondrial

1

2

High-throughput

0.489

High

1117960

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1117972

CPLX3
Complexin-3

1

1

High-throughput

0.489

High

1117995

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.489

High

141476

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

179203

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

9

Small-scale

0.479

High

293671

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

302515

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

High-throughput

0.479

High

349073

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

443784

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

3

High-throughput

0.479

High

456723

ANXA2
Annexin A2

1

3

High-throughput

0.479

High

457863

INVO
Involucrin

1

7

High-throughput

0.479

High

485131

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.479

High

566373

K2C5
Keratin, type II cytoskeletal 5

1

4

Small-scale

0.479

High

618030

K1C15
Keratin, type I cytoskeletal 15

1

8

Small-scale

0.479

High

635587

FILA
Filaggrin

1

6

High-throughput

0.479

High

655823

TBG1
Tubulin gamma-1 chain

1

5

High-throughput

0.479

High

695416

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

713376

SPB3
Serpin B3

1

6

High-throughput

0.479

High

729552

CASPE
Caspase-14

1

4

High-throughput

0.479

High

765491

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.479

High

768147

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

787641

SPB5
Serpin B5

1

7

High-throughput

0.479

High

830704

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

888047

MCM2
DNA replication licensing factor MCM2

1

15

High-throughput

0.479

High

908825

NEK2
Serine/threonine-protein kinase Nek2

1

6

Small-scale

0.479

High

970472

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

986414

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

1026370

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

1062230

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.479

High

1095991

TADBP
TAR DNA-binding protein 43

1

7

High-throughput

0.479

High

1106839

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1117937

DX39B
Spliceosome RNA helicase DDX39B

1

10

High-throughput

0.479

High

1117939

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.479

High

1117945

FILA2
Filaggrin-2

1

10

High-throughput

0.479

High

1117948

MYOME
Myomegalin

1

20

High-throughput

0.479

High

1117952

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1117958

TRI50
E3 ubiquitin-protein ligase TRIM50

1

5

Small-scale

0.479

High

1117970

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.479

High

1117975

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

High-throughput

0.479

High

1117978

FBXW7
F-box/WD repeat-containing protein 7

1

20

High-throughput

0.479

High

1117982

SPB12
Serpin B12

1

6

High-throughput

0.479

High

1117983

RANB9
Ran-binding protein 9

1

6

Small-scale

0.479

High

1117984

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1117990

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1117991

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1117992

DDX24
ATP-dependent RNA helicase DDX24

1

7

High-throughput

0.479

High

1117994

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1117996

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1117997

ANLN
Anillin

1

7

High-throughput

0.479

High

1118003

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

1040797

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1117938

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

1117973

POF1B
Protein POF1B

1

0

High-throughput

0.458

High

563737

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

952157

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.445

High

1117944

ODFP2
Outer dense fiber protein 2

1

11

High-throughput

0.445

High

1117947

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1117967

MSPD2
Motile sperm domain-containing protein 2

1

1

High-throughput

0.445

High

1117993

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

7

High-throughput

0.445

High

105901

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

456230

CATD
Cathepsin D

1

1

High-throughput

0.437

High

1117965

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

1117950

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.407

High

1117964

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

4

High-throughput

0.407

High

1117969

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

231225

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

331864

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.279

Low

755480

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

1087049

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.279

Low

1117941

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.279

Low

1117963

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

1117971

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1118002

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1093461

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.249

Low

1117977

WNT2B
Protein Wnt-2b

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025