Protein: ZC3C1
Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase)

Gene: ZC3C1, ZC3HC1
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q86WB0

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
GO:0019901 - protein kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992240

SKP1
S-phase kinase-associated protein 1

8

0

Small-scale

0.718

High

552829

TPR
Nucleoprotein TPR

4

1

Small-scale

0.692

High

920086

PLK1
Serine/threonine-protein kinase PLK1

4

0

High-throughput

0.670

High

573854

CCNB1
G2/mitotic-specific cyclin-B1

4

0

Small-scale

0.666

High

1292344

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

3

0

High-throughput

0.638

High

1112581

CUL1
Cullin-1

2

1

Small-scale

0.624

High

703638

MK01
Mitogen-activated protein kinase 1

2

1

Small-scale

0.619

High

1292341

NXF2
Nuclear RNA export factor 2

2

0

High-throughput

0.602

High

1292342

GAN
Gigaxonin

2

0

High-throughput

0.576

High

980894

H2B1C
Histone H2B type 1-C/E/F/G/I

2

0

High-throughput

0.559

High

248733

PEPL
Periplakin

2

3

High-throughput

0.549

High

787671

SPB5
Serpin B5

2

4

High-throughput

0.549

High

1292327

EVPL
Envoplakin

2

5

High-throughput

0.549

High

436696

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

1292356

FZR1
Fizzy-related protein homolog

1

0

Small-scale

0.537

High

407649

S100B
Protein S100-B

1

3

High-throughput

0.536

High

587724

DESP
Desmoplakin

1

3

High-throughput

0.536

High

635610

FILA
Filaggrin

1

3

High-throughput

0.536

High

868728

LEG7
Galectin-7

1

1

High-throughput

0.536

High

1036761

DSG1
Desmoglein-1

1

2

High-throughput

0.536

High

1117956

PKP1
Plakophilin-1

1

2

High-throughput

0.536

High

1292317

RDHE2
Epidermal retinol dehydrogenase 2

1

1

High-throughput

0.536

High

1292349

IL36G
Interleukin-36 gamma

1

1

High-throughput

0.536

High

1292354

SPB13
Serpin B13

1

4

High-throughput

0.536

High

1292358

PKP3
Plakophilin-3

1

2

High-throughput

0.536

High

126242

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

129232

MEN1
Menin

1

0

High-throughput

0.513

High

384694

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.513

High

423675

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

577811

PLAK
Junction plakoglobin

1

0

High-throughput

0.513

High

729585

CASPE
Caspase-14

1

0

High-throughput

0.513

High

1120917

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.513

High

1244455

DCNL2
DCN1-like protein 2

1

0

High-throughput

0.513

High

1292315

AHNK2
Protein AHNAK2

1

0

High-throughput

0.513

High

1292334

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1292336

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

1292345

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

1292348

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.513

High

1292359

SALL2
Sal-like protein 2

1

0

High-throughput

0.513

High

691785

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.501

High

488511

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

High-throughput

0.493

High

927391

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

1279603

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

220093

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.489

High

276601

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.489

High

289265

SPB7
Serpin B7

1

5

High-throughput

0.489

High

424519

PAI2
Plasminogen activator inhibitor 2

1

4

High-throughput

0.489

High

592857

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.489

High

652347

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.489

High

706197

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

722795

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.489

High

892113

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

895452

SPB8
Serpin B8

1

4

High-throughput

0.489

High

945814

EPIPL
Epiplakin

1

3

High-throughput

0.489

High

1062256

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.489

High

1064448

DSC1
Desmocollin-1

1

1

High-throughput

0.489

High

1128527

DSC3
Desmocollin-3

1

2

High-throughput

0.489

High

1192164

LEGL
Galectin-related protein

1

1

High-throughput

0.489

High

1292316

SPA12
Serpin A12

1

4

High-throughput

0.489

High

1292321

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.489

High

1292339

LOXE3
Hydroperoxide isomerase ALOXE3

1

1

High-throughput

0.489

High

1292350

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.489

High

1292353

I36RA
Interleukin-36 receptor antagonist protein

1

1

High-throughput

0.489

High

193593

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

High-throughput

0.486

High

1152437

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.486

High

1292328

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.481

High

1292340

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.481

High

971733

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.480

High

831007

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

966561

1433G
14-3-3 protein gamma

1

1

High-throughput

0.479

High

1113588

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1254479

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

227602

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

242176

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

700681

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

942725

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

983870

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1008793

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.458

High

1067480

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1097397

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1276435

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1292314

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.458

High

1292320

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

575156

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.426

High

711717

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.426

High

1216221

H37
Histone H3-7

1

0

High-throughput

0.426

High

1292324

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.407

High

1292346

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.407

High

1292351

KLK14
Kallikrein-14

1

1

High-throughput

0.407

High

1292352

CRNN
Cornulin

1

3

High-throughput

0.407

High

705447

GRN
Progranulin

3

0

High-throughput

0.347

High

1292322

VATC2
V-type proton ATPase subunit C 2

3

0

High-throughput

0.342

High

1279004

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

1292319

SRBD1
S1 RNA-binding domain-containing protein 1

2

0

High-throughput

0.328

High

1292333

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

1292323

AT2L1
Ethanolamine-phosphate phospho-lyase

2

0

High-throughput

0.324

High

1248145

SAS6
Spindle assembly abnormal protein 6 homolog

2

0

High-throughput

0.319

High

1256954

FBX50
F-box only protein 50

2

0

High-throughput

0.313

High

1292326

POF1B
Protein POF1B

2

0

High-throughput

0.313

High

1292357

ALK
ALK tyrosine kinase receptor

1

0

Small-scale

0.301

High

161880

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.279

Low

174776

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

0

High-throughput

0.279

Low

350317

LY66C
Lymphocyte antigen 6 complex locus protein G6c

1

0

High-throughput

0.279

Low

457878

INVO
Involucrin

1

0

High-throughput

0.279

Low

636175

ENDOU
Uridylate-specific endoribonuclease

1

0

High-throughput

0.279

Low

649740

SPR1B
Cornifin-B

1

0

High-throughput

0.279

Low

692738

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1142993

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.279

Low

1149514

CDSN
Corneodesmosin

1

0

High-throughput

0.279

Low

1200312

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

1200349

APRV1
Retroviral-like aspartic protease 1

1

0

High-throughput

0.279

Low

1248700

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

1272454

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

1292325

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

0

High-throughput

0.279

Low

1292330

RDH12
Retinol dehydrogenase 12

1

0

High-throughput

0.279

Low

1292331

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

1292332

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1292335

SEPT5
Septin-5

1

0

High-throughput

0.279

Low

1292337

TPPP3
Tubulin polymerization-promoting protein family member 3

1

0

High-throughput

0.279

Low

1292338

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.279

Low

1292347

PICK1
PRKCA-binding protein

1

0

High-throughput

0.279

Low

1292355

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.279

Low

164696

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.265

Low

422479

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

755497

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.249

Low

1292318

ARL14
ADP-ribosylation factor-like protein 14

1

0

High-throughput

0.249

Low

1292343

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

69510

A2ML1
Alpha-2-macroglobulin-like protein 1

1

0

High-throughput

0.232

Low

358887

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.232

Low

379267

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.232

Low

839579

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

963197

LYSC
Lysozyme C

1

0

High-throughput

0.232

Low

1048469

AK1C1
Aldo-keto reductase family 1 member C1

1

0

High-throughput

0.232

Low

1157293

PROL4
Proline-rich protein 4

1

0

High-throughput

0.232

Low

1292329

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025