HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	17620599, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0015031 - protein transport GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 418
+	Hs
		827176 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		433291 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		522859 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Mm
		980969 YES_MOUSE (556-728): 3.4e-30: 127: 18.79		ARRB1_MOUSE (1-418): 0: 703: 98.57
+	Mm
		403452 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		ARRB1_MOUSE (1-418): 0: 703: 98.57
+	Hs
		782757 CSK_HUMAN (324-446): 1.13e-24: 109: 26.02		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		522813 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Mm
		403455 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		ARRB2_MOUSE (1-407): 0: 615: 75.00
+	Hs
		685825 CSK_HUMAN (324-446): 1.13e-24: 109: 26.02		ARRB2_HUMAN (1-407): 0: 626: 76.15