HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: FXL15 (Q9H469)
F-box/LRR-repeat protein 15 (F-box only protein 37)
Gene: FBXL15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21572392
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 300
+	Hs
		1327912 WWP1_HUMAN (1-903): 0: 832: 57.54		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		125710 WWP2_HUMAN (1-903): 0: 816: 54.08		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1299633 NED4L_HUMAN (5-900): 0: 762: 32.14		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		808271 NEDD4_HUMAN (90-900): 0: 673: 34.16		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		808329 NEDD4_HUMAN (90-900): 0: 673: 34.16		KDM2A_HUMAN (24-284): 2.19e-35: 137: 15.88
+	Hs
		1330594 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1330593 SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1336111 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		FBXL2_HUMAN (5-249): 1.36e-30: 120: 22.05
+	Hs
		1330595 HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1176348 HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00