Protein: EI2BA
Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)

Gene: EI2BA, EIF2B1
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q14232

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1124182

EI2BA
Translation initiation factor eIF2B subunit alpha

5

13

Small-scale

0.918

High

1124236

EI2BG
Translation initiation factor eIF2B subunit gamma

4

15

High-throughput

0.900

High

890117

EI2BB
Translation initiation factor eIF2B subunit beta

4

14

Small-scale

0.895

High

1124240

EI2BD
Translation initiation factor eIF2B subunit delta

3

14

High-throughput

0.861

High

1095879

EI2BE
Translation initiation factor eIF2B subunit epsilon

5

19

Small-scale

0.716

High

1124234

GORS2
Golgi reassembly-stacking protein 2

5

0

High-throughput

0.691

High

1124200

RD3
Protein RD3

4

0

High-throughput

0.668

High

1124220

NTAQ1
Protein N-terminal glutamine amidohydrolase

4

0

High-throughput

0.668

High

733495

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.667

High

845424

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

10

High-throughput

0.667

High

1124222

NECT4
Nectin-4

3

5

High-throughput

0.667

High

1124226

P2RX4
P2X purinoceptor 4

3

2

High-throughput

0.667

High

1124238

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

2

High-throughput

0.667

High

1124243

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.667

High

1124208

SIGL1
SIGLEC family-like protein 1

3

2

High-throughput

0.662

High

426269

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

4

Small-scale

0.647

High

1124203

STX12
Syntaxin-12

4

2

High-throughput

0.630

High

438078

GLPB
Glycophorin-B

2

4

High-throughput

0.628

High

1022852

EFNB1
Ephrin-B1

2

5

High-throughput

0.601

High

1124184

CD226
CD226 antigen

2

6

High-throughput

0.601

High

1124209

SYT2
Synaptotagmin-2

2

5

High-throughput

0.601

High

1124241

CC018
Uncharacterized protein C3orf18

2

2

High-throughput

0.601

High

1124247

5MP1
eIF5-mimic protein 1

2

9

Small-scale

0.595

High

241665

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

363279

EGFR
Epidermal growth factor receptor

2

4

Small-scale

0.584

High

1124183

TNIP1
TNFAIP3-interacting protein 1

2

1

High-throughput

0.584

High

1124207

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

0

High-throughput

0.580

High

1124246

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

0

High-throughput

0.580

High

1124191

A16L1
Autophagy-related protein 16-1

2

7

High-throughput

0.571

High

458396

ADRB2
Beta-2 adrenergic receptor

1

1

Small-scale

0.561

High

886269

ARL4D
ADP-ribosylation factor-like protein 4D

1

1

High-throughput

0.541

High

140913

NOP56
Nucleolar protein 56

1

2

High-throughput

0.536

High

250608

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.536

High

486559

TACD2
Tumor-associated calcium signal transducer 2

1

2

High-throughput

0.536

High

592721

LEUK
Leukosialin

1

2

High-throughput

0.536

High

621872

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.536

High

669269

PTAFR
Platelet-activating factor receptor

1

9

High-throughput

0.536

High

683240

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

High-throughput

0.536

High

693735

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

762403

BTC
Probetacellulin [Cleaved into: Betacellulin

1

2

High-throughput

0.536

High

832039

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

7

High-throughput

0.536

High

845973

DCC
Netrin receptor DCC

1

2

Small-scale

0.536

High

933317

IF5
Eukaryotic translation initiation factor 5

1

7

High-throughput

0.536

High

958264

ARP2
Actin-related protein 2

1

3

High-throughput

0.536

High

1027451

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1124194

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.536

High

1124202

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

2

High-throughput

0.536

High

1124206

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.536

High

1124214

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.536

High

1124224

SEC62
Translocation protein SEC62

1

2

High-throughput

0.536

High

1124244

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.536

High

576398

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

High-throughput

0.515

High

912562

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.515

High

964112

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.513

High

1124212

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.513

High

1124213

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1124219

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.513

High

1124225

SORT
Sortilin

1

0

High-throughput

0.513

High

1124227

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.513

High

612346

ADA2B
Alpha-2B adrenergic receptor

1

2

Small-scale

0.501

High

616698

ADA2C
Alpha-2C adrenergic receptor

1

2

Small-scale

0.501

High

1124229

RM04
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.494

High

772796

MYH9
Myosin-9

1

0

High-throughput

0.493

High

1010620

DCD
Dermcidin

1

0

High-throughput

0.493

High

1124185

STK11
Serine/threonine-protein kinase STK11

1

0

Small-scale

0.493

High

484530

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1124230

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

1124245

EXOG
Nuclease EXOG, mitochondrial

1

3

High-throughput

0.489

High

993566

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

47982

RBM47
RNA-binding protein 47

1

1

High-throughput

0.479

High

172808

XPO1
Exportin-1

1

10

High-throughput

0.479

High

315581

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

400826

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

411921

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

659474

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

661267

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

2

High-throughput

0.479

High

710239

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

710832

EPHB2
Ephrin type-B receptor 2

1

4

High-throughput

0.479

High

830724

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

931946

EPHB4
Ephrin type-B receptor 4

1

4

High-throughput

0.479

High

971520

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.479

High

1024574

VIGLN
Vigilin

1

1

High-throughput

0.479

High

1047003

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

4

Small-scale

0.479

High

1106855

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1124186

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.479

High

1124192

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1124195

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1124218

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1124221

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1124232

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1124239

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1124196

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

332758

EPM2A
Laforin

1

0

Small-scale

0.460

High

485139

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

787018

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.458

High

867123

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1096540

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1124188

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1124216

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

388195

GLPA
Glycophorin-A

1

4

High-throughput

0.445

High

532172

CD28
T-cell-specific surface glycoprotein CD28

1

2

High-throughput

0.445

High

639132

SYT1
Synaptotagmin-1

1

5

High-throughput

0.445

High

754023

CD80
T-lymphocyte activation antigen CD80

1

4

High-throughput

0.445

High

914414

EFNB2
Ephrin-B2

1

5

High-throughput

0.445

High

934603

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

1124189

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1124217

IGSF8
Immunoglobulin superfamily member 8

1

2

High-throughput

0.445

High

1124223

CK5P2
CDK5 regulatory subunit-associated protein 2

1

4

High-throughput

0.445

High

1124233

PACC1
Proton-activated chloride channel

1

2

High-throughput

0.445

High

259938

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

588681

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695439

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768174

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1124199

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1124211

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.437

High

1124215

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1124231

EMRE
Essential MCU regulator, mitochondrial

1

2

High-throughput

0.437

High

1124242

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

1124210

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.426

High

429878

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

1124201

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.407

High

1124205

TM192
Transmembrane protein 192

1

1

High-throughput

0.407

High

288170

CLC3A
C-type lectin domain family 3 member A

2

0

High-throughput

0.328

High

1124198

BHA15
Class A basic helix-loop-helix protein 15

2

0

High-throughput

0.328

High

1124204

TRI59
Tripartite motif-containing protein 59

2

0

High-throughput

0.316

High

1124228

CA050
Uncharacterized protein C1orf50

2

0

High-throughput

0.316

High

1124237

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.316

High

1124235

LUC7L
Putative RNA-binding protein Luc7-like 1

2

0

High-throughput

0.298

High

244695

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

410476

PRM2
Protamine-2

1

0

High-throughput

0.279

Low

1124248

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

566669

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.269

Low

1124187

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1124193

FOXR2
Forkhead box protein R2

1

0

High-throughput

0.249

Low

1124197

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

337727

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.232

Low

1124190

Z385C
Zinc finger protein 385C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025