Protein: EI2BB
Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)

Gene: EI2BB, EIF2B2
Organism: Homo sapiens
Interactions: 110
UniProt ID: P49770

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890170

EI2BD
Translation initiation factor eIF2B subunit delta

8

15

High-throughput

0.971

High

890117

EI2BA
Translation initiation factor eIF2B subunit alpha

4

14

Small-scale

0.895

High

890167

EI2BG
Translation initiation factor eIF2B subunit gamma

3

15

High-throughput

0.861

High

890114

EI2BE
Translation initiation factor eIF2B subunit epsilon

4

19

Small-scale

0.696

High

890154

CI072
Guanine nucleotide exchange factor C9orf72

4

3

High-throughput

0.690

High

890161

OPN3
Opsin-3

3

3

High-throughput

0.667

High

890168

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

2

High-throughput

0.667

High

171413

S27A2
Long-chain fatty acid transport protein 2

3

1

High-throughput

0.662

High

639110

SYT1
Synaptotagmin-1

3

5

High-throughput

0.662

High

890138

STX12
Syntaxin-12

4

2

High-throughput

0.630

High

507118

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

2

High-throughput

0.628

High

640123

EPHA1
Ephrin type-A receptor 1

2

4

High-throughput

0.628

High

890109

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

3

High-throughput

0.628

High

890120

VAMP3
Vesicle-associated membrane protein 3

2

1

High-throughput

0.628

High

845959

DCC
Netrin receptor DCC

2

2

Small-scale

0.611

High

890158

P2RX4
P2X purinoceptor 4

2

2

High-throughput

0.611

High

733488

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.609

High

845409

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

10

High-throughput

0.609

High

890105

EFNB2
Ephrin-B2

3

5

High-throughput

0.609

High

890155

NECT4
Nectin-4

3

5

High-throughput

0.609

High

890173

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.609

High

890142

SIGL1
SIGLEC family-like protein 1

3

2

High-throughput

0.604

High

890111

EFNB1
Ephrin-B1

2

5

High-throughput

0.601

High

362975

EGFR
Epidermal growth factor receptor

2

4

High-throughput

0.584

High

438071

GLPB
Glycophorin-B

2

4

High-throughput

0.574

High

890144

GOLM1
Golgi membrane protein 1

2

1

High-throughput

0.574

High

890175

EXOG
Nuclease EXOG, mitochondrial

2

3

High-throughput

0.574

High

890127

A16L1
Autophagy-related protein 16-1

2

7

High-throughput

0.571

High

592716

LEUK
Leukosialin

2

2

High-throughput

0.558

High

683213

TNR5
Tumor necrosis factor receptor superfamily member 5

2

2

High-throughput

0.549

High

890119

CD226
CD226 antigen

2

6

High-throughput

0.549

High

890143

SYT2
Synaptotagmin-2

2

5

High-throughput

0.549

High

890164

PACC1
Proton-activated chloride channel

2

2

High-throughput

0.549

High

890171

CC018
Uncharacterized protein C3orf18

2

2

High-throughput

0.549

High

881828

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.541

High

486548

TACD2
Tumor-associated calcium signal transducer 2

1

2

High-throughput

0.536

High

648267

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

1

High-throughput

0.536

High

693606

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

831965

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

7

High-throughput

0.536

High

890107

IF5
Eukaryotic translation initiation factor 5

1

7

High-throughput

0.536

High

890110

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

890112

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

3

High-throughput

0.536

High

890118

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.536

High

890131

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.536

High

890150

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.536

High

890174

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.536

High

890176

E41L3
Band 4.1-like protein 3

1

1

High-throughput

0.536

High

890177

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

890151

IGSF8
Immunoglobulin superfamily member 8

2

2

High-throughput

0.521

High

890108

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.513

High

890159

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

253823

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

484434

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

669262

PTAFR
Platelet-activating factor receptor

1

9

High-throughput

0.489

High

749182

CD70
CD70 antigen

1

1

High-throughput

0.489

High

762401

BTC
Probetacellulin [Cleaved into: Betacellulin

1

2

High-throughput

0.489

High

890115

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

10

High-throughput

0.489

High

890129

GOLM2
Protein GOLM2

1

1

High-throughput

0.489

High

890133

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

890136

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

2

High-throughput

0.489

High

890141

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

890148

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

890149

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.489

High

890157

SEC62
Translocation protein SEC62

1

2

High-throughput

0.489

High

890165

PCDH9
Protocadherin-9

1

1

High-throughput

0.489

High

625252

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.481

High

421727

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

172584

XPO1
Exportin-1

1

10

High-throughput

0.479

High

241091

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

315287

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

445782

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

487088

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

890132

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

890134

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

890153

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

890163

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

890169

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

890172

AGO1
Protein argonaute-1

1

1

High-throughput

0.479

High

890178

5MP1
eIF5-mimic protein 1

1

9

High-throughput

0.479

High

890116

CUL3
Cullin-3

1

0

High-throughput

0.458

High

890124

RC3H1
Roquin-1

1

0

High-throughput

0.458

High

388168

GLPA
Glycophorin-A

1

4

High-throughput

0.445

High

532164

CD28
T-cell-specific surface glycoprotein CD28

1

2

High-throughput

0.445

High

722866

SSR2
Somatostatin receptor type 2

1

6

High-throughput

0.445

High

890123

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

890137

STING
Stimulator of interferon genes protein

1

1

Small-scale

0.445

High

890156

CK5P2
CDK5 regulatory subunit-associated protein 2

1

4

High-throughput

0.445

High

890152

MR1L1
MORF4 family-associated protein 1-like 1

1

2

High-throughput

0.439

High

588202

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

694927

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

767696

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

890130

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

890140

PNKD
Probable thioesterase PNKD

1

1

High-throughput

0.437

High

890146

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.437

High

890162

EMRE
Essential MCU regulator, mitochondrial

1

2

High-throughput

0.437

High

890121

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

890106

MOT1
Monocarboxylate transporter 1

1

1

High-throughput

0.407

High

890135

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.407

High

890139

TM192
Transmembrane protein 192

1

1

High-throughput

0.407

High

890166

SO1B3
Solute carrier organic anion transporter family member 1B3

1

2

High-throughput

0.407

High

890113

NTCP7
Sodium/bile acid cotransporter 7

2

0

High-throughput

0.328

High

890125

MFS4B
Sodium-dependent glucose transporter 1

2

0

High-throughput

0.328

High

890145

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.328

High

890128

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.288

High

890122

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.279

Low

890126

TM164
Transmembrane protein 164

1

0

High-throughput

0.279

Low

890147

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.279

Low

890160

PCGF6
Polycomb group RING finger protein 6

1

0

High-throughput

0.251

Low

71198

HIDE1
Protein HIDE1

1

0

High-throughput

0.232

Low

760415

SDC2
Syndecan-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025