HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: GGA3 (Q9NZ52)
ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Gene: GGA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25195858
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031901 - early endosome membrane GO:0032991 - protein-containing complex GO:0045732 - positive regulation of protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 723
+	Hs
		277114 ITCH_HUMAN (1-903): 0: 926: 100.00		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		1270607 ITCH_HUMAN (1-903): 0: 926: 100.00		STAM1_HUMAN (1-522): 4.18e-75: 254: 17.10
+	Hs
		160143 ITCH_HUMAN (1-903): 0: 926: 100.00		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		808298 NEDD4_HUMAN (90-900): 0: 673: 34.16		GGA3_HUMAN (1-723): 3.49e-148: 451: 100.00
+	Hs
		125533 WWP2_HUMAN (1-903): 0: 816: 54.08		TM1L2_HUMAN (7-511): 5.58e-88: 287: 21.58
+	Hs
		125035 WWP2_HUMAN (1-903): 0: 816: 54.08		TOM1_HUMAN (7-402): 8.19e-85: 278: 22.76
+	Hs
		125613 WWP2_HUMAN (1-903): 0: 816: 54.08		STAM1_HUMAN (1-522): 4.18e-75: 254: 17.10
+	Hs
		125001 WWP2_HUMAN (1-903): 0: 816: 54.08		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		160160 NED4L_HUMAN (5-900): 0: 762: 32.14		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		808171 NEDD4_HUMAN (90-900): 0: 673: 34.16		TM1L2_HUMAN (7-511): 5.58e-88: 287: 21.58
+	Hs
		241153 NEDD4_HUMAN (90-900): 0: 673: 34.16		TOM1_HUMAN (7-402): 8.19e-85: 278: 22.76
+	Hs
		159925 NEDD4_HUMAN (90-900): 0: 673: 34.16		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		276359 NEDD4_HUMAN (90-900): 0: 673: 34.16		AP1G2_HUMAN (602-720): 5.74e-10: 64.7: 32.77
+	Hs
		1173029 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		TM1L2_HUMAN (7-511): 5.58e-88: 287: 21.58
+	Hs
		241199 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		TOM1_HUMAN (7-402): 8.19e-85: 278: 22.76
+	Sc
		765278 RSP5_YEAST (16-440): 9.75e-40: 160: 19.07		VPS27_YEAST (1-595): 9.4e-65: 228: 14.56