Protein: ZNT8
Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8)

Gene: ZNT8, SLC30A8
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q8IWU4

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005385 - zinc ion transmembrane transporter activity
GO:0005886 - plasma membrane
GO:0006829 - zinc ion transport
GO:0006882 - intracellular zinc ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1310934

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

16

High-throughput

0.783

High

1310912

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

4

2

High-throughput

0.647

High

252611

TSN2
Tetraspanin-2

2

6

High-throughput

0.606

High

258647

G37L1
G-protein coupled receptor 37-like 1

2

7

High-throughput

0.606

High

328946

RTN3
Reticulon-3

2

1

High-throughput

0.606

High

339224

SFT2B
Vesicle transport protein SFT2B

2

1

High-throughput

0.606

High

592942

ANK1
Ankyrin-1

2

4

High-throughput

0.606

High

602241

TMM11
Transmembrane protein 11, mitochondrial

2

1

High-throughput

0.606

High

662352

VAMP1
Vesicle-associated membrane protein 1

2

7

High-throughput

0.606

High

719980

HMOX2
Heme oxygenase 2

2

1

High-throughput

0.606

High

926802

VMAT1
Chromaffin granule amine transporter

2

6

High-throughput

0.606

High

989354

VAMP2
Vesicle-associated membrane protein 2

2

6

High-throughput

0.606

High

1281170

CPLX4
Complexin-4

2

1

High-throughput

0.606

High

1310896

RELL2
RELT-like protein 2

2

2

High-throughput

0.606

High

1310900

C99L2
CD99 antigen-like protein 2

2

2

High-throughput

0.606

High

1310901

SFT2A
Vesicle transport protein SFT2A

2

1

High-throughput

0.606

High

1310914

YIPF6
Protein YIPF6

2

4

High-throughput

0.606

High

1310933

CGRF1
Cell growth regulator with RING finger domain protein 1

2

1

High-throughput

0.606

High

1310938

YIPF4
Protein YIPF4

2

4

High-throughput

0.606

High

1310956

S39A2
Zinc transporter ZIP2

2

4

High-throughput

0.606

High

1310969

SCN3B
Sodium channel regulatory subunit beta-3

2

5

High-throughput

0.606

High

1310971

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

2

2

High-throughput

0.606

High

590305

MUC1
Mucin-1

2

0

High-throughput

0.580

High

688397

PPLA
Phospholamban

2

0

High-throughput

0.580

High

951941

SYCY2
Syncytin-2

2

0

High-throughput

0.580

High

1126118

GRM2
Metabotropic glutamate receptor 2

2

0

High-throughput

0.580

High

1159477

NKG7
Protein NKG7

2

0

High-throughput

0.580

High

1212745

ZFY27
Protrudin

2

0

High-throughput

0.580

High

1310891

SYS1
Protein SYS1 homolog

2

0

High-throughput

0.580

High

1310893

SYT2
Synaptotagmin-2

2

0

High-throughput

0.580

High

1310904

THAP4
Peroxynitrite isomerase THAP4

2

0

High-throughput

0.580

High

1310905

BSND
Barttin

2

0

High-throughput

0.580

High

1310927

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

1310931

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

2

0

High-throughput

0.580

High

1310939

TM208
Transmembrane protein 208

2

0

High-throughput

0.580

High

1310992

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

181367

PGRC2
Membrane-associated progesterone receptor component 2

2

2

High-throughput

0.553

High

561040

CCL4
C-C motif chemokine 4

2

3

High-throughput

0.553

High

849016

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

4

High-throughput

0.553

High

1108953

AQP6
Aquaporin-6

2

3

High-throughput

0.553

High

1195238

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.553

High

1310895

DHB11
Estradiol 17-beta-dehydrogenase 11

2

6

High-throughput

0.553

High

1310916

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

1

High-throughput

0.553

High

1310919

TMM80
Transmembrane protein 80

2

2

High-throughput

0.553

High

1310920

REEP6
Receptor expression-enhancing protein 6

2

2

High-throughput

0.553

High

1310923

F210B
Protein FAM210B, mitochondrial

2

2

High-throughput

0.553

High

1310929

RMD3
Regulator of microtubule dynamics protein 3

2

2

High-throughput

0.553

High

1310940

DERL1
Derlin-1

2

1

High-throughput

0.553

High

1310948

ELOV4
Very long chain fatty acid elongase 4

2

7

High-throughput

0.553

High

1310951

REEP4
Receptor expression-enhancing protein 4

2

2

High-throughput

0.553

High

1310953

AT131
Endoplasmic reticulum transmembrane helix translocase

2

6

High-throughput

0.553

High

1310961

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

1310962

OTULL
Inactive ubiquitin thioesterase OTULINL

2

4

High-throughput

0.553

High

1310966

ARL8B
ADP-ribosylation factor-like protein 8B

2

11

High-throughput

0.553

High

193426

GPR42
G-protein coupled receptor 42

1

19

High-throughput

0.515

High

1310947

THS7B
Thrombospondin type-1 domain-containing protein 7B

1

5

High-throughput

0.515

High

1310984

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

7

High-throughput

0.515

High

942275

CLD6
Claudin-6

1

0

High-throughput

0.493

High

1142871

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.493

High

1310903

SSMM1
Serine-rich single-pass membrane protein 1

1

1

High-throughput

0.470

High

1310959

SAR1A
Small COPII coat GTPase SAR1A

1

13

High-throughput

0.470

High

718711

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.460

High

791515

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

125762

STXB3
Syntaxin-binding protein 3

1

7

High-throughput

0.445

High

169642

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.445

High

189686

STX7
Syntaxin-7

1

7

High-throughput

0.445

High

239856

PCDH7
Protocadherin-7

1

11

High-throughput

0.445

High

243808

ADCY3
Adenylate cyclase type 3

1

3

High-throughput

0.445

High

287585

LRP6
Low-density lipoprotein receptor-related protein 6

1

4

High-throughput

0.445

High

322968

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

4

High-throughput

0.445

High

331891

GOSR1
Golgi SNAP receptor complex member 1

1

6

High-throughput

0.445

High

350247

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.445

High

390656

TFR1
Transferrin receptor protein 1

1

4

High-throughput

0.445

High

410933

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

9

High-throughput

0.445

High

582178

INGR1
Interferon gamma receptor 1

1

3

High-throughput

0.445

High

600506

ZNF3
Zinc finger protein 3

1

1

High-throughput

0.445

High

604081

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.445

High

699798

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

High-throughput

0.445

High

773554

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.445

High

777719

VGFR3
Vascular endothelial growth factor receptor 3

1

4

High-throughput

0.445

High

857496

NOTC1
Neurogenic locus notch homolog protein 1

1

8

High-throughput

0.445

High

890354

NU153
Nuclear pore complex protein Nup153

1

5

High-throughput

0.445

High

921710

COPB
Coatomer subunit beta

1

6

High-throughput

0.445

High

1008436

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

4

High-throughput

0.445

High

1037007

DSC2
Desmocollin-2

1

13

High-throughput

0.445

High

1063408

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.445

High

1083122

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

20

High-throughput

0.445

High

1085445

SRBP2
Sterol regulatory element-binding protein 2

1

3

High-throughput

0.445

High

1087178

STX4
Syntaxin-4

1

7

High-throughput

0.445

High

1097827

STX5
Syntaxin-5

1

13

High-throughput

0.445

High

1104435

ILK
Scaffold protein ILK

1

2

High-throughput

0.445

High

1105856

TMED1
Transmembrane emp24 domain-containing protein 1

1

12

High-throughput

0.445

High

1118377

BMPR2
Bone morphogenetic protein receptor type-2

1

2

High-throughput

0.445

High

1128531

DSC3
Desmocollin-3

1

11

High-throughput

0.445

High

1129832

EPN4
Clathrin interactor 1

1

3

High-throughput

0.445

High

1144632

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

4

High-throughput

0.445

High

1145000

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.445

High

1147368

EPHA7
Ephrin type-A receptor 7

1

5

High-throughput

0.445

High

1208110

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

11

High-throughput

0.445

High

1210069

SNP47
Synaptosomal-associated protein 47

1

4

High-throughput

0.445

High

1245089

RHDF2
Inactive rhomboid protein 2

1

3

High-throughput

0.445

High

1249971

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

2

High-throughput

0.445

High

1278282

LRP10
Low-density lipoprotein receptor-related protein 10

1

7

High-throughput

0.445

High

1290574

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.445

High

1293255

LSR
Lipolysis-stimulated lipoprotein receptor

1

1

High-throughput

0.445

High

1307996

RELL1
RELT-like protein 1

1

2

High-throughput

0.445

High

1310897

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.445

High

1310898

VANG1
Vang-like protein 1

1

1

High-throughput

0.445

High

1310902

SCFD1
Sec1 family domain-containing protein 1

1

7

High-throughput

0.445

High

1310909

NEO1
Neogenin

1

1

High-throughput

0.445

High

1310911

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.445

High

1310922

KIRR1
Kin of IRRE-like protein 1

1

5

High-throughput

0.445

High

1310925

ANR27
Ankyrin repeat domain-containing protein 27

1

5

High-throughput

0.445

High

1310930

PKP4
Plakophilin-4

1

6

High-throughput

0.445

High

1310932

OSMR
Oncostatin-M-specific receptor subunit beta

1

2

High-throughput

0.445

High

1310935

PKP2
Plakophilin-2

1

6

High-throughput

0.445

High

1310937

ESYT1
Extended synaptotagmin-1

1

5

High-throughput

0.445

High

1310942

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.445

High

1310944

CADM1
Cell adhesion molecule 1

1

5

High-throughput

0.445

High

1310945

B3GN5
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

1

14

High-throughput

0.445

High

1310946

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.445

High

1310952

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

1

High-throughput

0.445

High

1310954

WDR6
tRNA

1

4

High-throughput

0.445

High

1310965

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.445

High

1310967

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.445

High

1310975

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

11

High-throughput

0.445

High

1310977

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

2

High-throughput

0.445

High

1310978

VANG2
Vang-like protein 2

1

1

High-throughput

0.445

High

1310979

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

10

High-throughput

0.445

High

1310980

NOTC3
Neurogenic locus notch homolog protein 3

1

8

High-throughput

0.445

High

1310981

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.445

High

1310982

PCDGK
Protocadherin gamma-C3

1

6

High-throughput

0.445

High

1310983

JAG2
Protein jagged-2

1

4

High-throughput

0.445

High

1310985

NISCH
Nischarin

1

1

High-throughput

0.445

High

1310987

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.445

High

1310989

RN115
E3 ubiquitin-protein ligase RNF115

1

4

High-throughput

0.445

High

1310990

LRP12
Low-density lipoprotein receptor-related protein 12

1

7

High-throughput

0.445

High

385936

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

High-throughput

0.439

High

584686

MCP
Membrane cofactor protein

1

0

High-throughput

0.426

High

702994

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.426

High

714252

PML
Protein PML

1

0

High-throughput

0.426

High

1095971

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

0

High-throughput

0.426

High

1144846

RABE1
Rab GTPase-binding effector protein 1

1

0

High-throughput

0.426

High

1310703

PHF6
PHD finger protein 6

1

0

High-throughput

0.426

High

1310928

ERBIN
Erbin

1

0

High-throughput

0.426

High

1310976

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.426

High

1310988

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.426

High

136410

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

9

High-throughput

0.407

High

161825

RIOK3
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.407

High

262537

MCE1
mRNA-capping enzyme

1

1

High-throughput

0.407

High

295206

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.407

High

295517

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

7

High-throughput

0.407

High

322423

HAUS5
HAUS augmin-like complex subunit 5

1

2

High-throughput

0.407

High

347796

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.407

High

660669

IF4B
Eukaryotic translation initiation factor 4B

1

2

High-throughput

0.407

High

679371

DNJB2
DnaJ homolog subfamily B member 2

1

2

High-throughput

0.407

High

958468

ACTZ
Alpha-centractin

1

1

High-throughput

0.407

High

1010494

EREP3
Protein ENTREP3

1

2

High-throughput

0.407

High

1102865

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.407

High

1147537

UBE3C
Ubiquitin-protein ligase E3C

1

6

High-throughput

0.407

High

1148250

RSU1
Ras suppressor protein 1

1

1

High-throughput

0.407

High

1218153

CAHD1
VWFA and cache domain-containing protein 1

1

1

High-throughput

0.407

High

1290450

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

4

High-throughput

0.407

High

1310889

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.407

High

1310890

RDH10
Retinol dehydrogenase 10

1

8

High-throughput

0.407

High

1310906

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.407

High

1310907

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

9

High-throughput

0.407

High

1310908

APBP2
Amyloid protein-binding protein 2

1

1

High-throughput

0.407

High

1310918

MYO19
Unconventional myosin-XIX

1

2

High-throughput

0.407

High

1310926

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

3

High-throughput

0.407

High

1310936

KLDC3
Kelch domain-containing protein 3

1

1

High-throughput

0.407

High

1310941

SFXN3
Sideroflexin-3

1

1

High-throughput

0.407

High

1310950

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

1

High-throughput

0.407

High

1310958

PDLI7
PDZ and LIM domain protein 7

1

2

High-throughput

0.407

High

1310963

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

1

High-throughput

0.407

High

1310968

BABA1
BRISC and BRCA1-A complex member 1

1

1

High-throughput

0.407

High

1310972

SENP1
Sentrin-specific protease 1

1

1

High-throughput

0.407

High

1310973

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

2

High-throughput

0.407

High

1310974

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.407

High

1310986

TR150
Thyroid hormone receptor-associated protein 3

1

3

High-throughput

0.407

High

71852

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

346715

TM50A
Transmembrane protein 50A

2

0

High-throughput

0.316

High

551146

PCNA
Proliferating cell nuclear antigen

2

0

High-throughput

0.316

High

1207542

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1308340

TM139
Transmembrane protein 139

2

0

High-throughput

0.316

High

1310917

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

1310921

FXDC2
Fatty acid hydroxylase domain-containing protein 2

2

0

High-throughput

0.316

High

1310924

JSPR1
Junctional sarcoplasmic reticulum protein 1

2

0

High-throughput

0.316

High

1310943

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.316

High

1310970

ORML1
ORM1-like protein 1

2

0

High-throughput

0.316

High

1102410

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.268

Low

1310899

FNDC9
Fibronectin type III domain-containing protein 9

1

0

High-throughput

0.268

Low

1310955

HM20A
High mobility group protein 20A

1

0

High-throughput

0.268

Low

1310957

SPAG4
Sperm-associated antigen 4 protein

1

0

High-throughput

0.268

Low

1207713

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

72664

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.232

Low

219976

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.232

Low

292166

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.232

Low

344239

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

829241

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.232

Low

922744

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.232

Low

1143636

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.232

Low

1310892

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.232

Low

1310894

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.232

Low

1310910

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.232

Low

1310913

FAF2
FAS-associated factor 2

1

0

High-throughput

0.232

Low

1310915

DAZP1
DAZ-associated protein 1

1

0

High-throughput

0.232

Low

1310949

TRABD
TraB domain-containing protein

1

0

High-throughput

0.232

Low

1310960

HELLS
Lymphoid-specific helicase

1

0

High-throughput

0.232

Low

1310964

INT9
Integrator complex subunit 9

1

0

High-throughput

0.232

Low

1310991

PEX16
Peroxisomal membrane protein PEX16

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025