HitPredict

Interactor 1: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Interactor 2: PAK6 (Q9NQU5)
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Gene: PAK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.80	0.700

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 681
+	Hs
		331035 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330976 RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		331065 RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330967 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		568715 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Sp
		963937 CDC42_SCHPO (32-217): 1.58e-88: 261: 52.15		SHK2_SCHPO (385-671): 6.04e-73: 248: 44.56
+	Dd
		710122 RACC_DICDI (32-214): 9.48e-88: 259: 46.45		PAKB_DICDI (388-676): 6.93e-65: 231: 45.39
+	Dd
		710121 RACB_DICDI (31-220): 5.71e-87: 257: 48.69		PAKB_DICDI (388-676): 6.93e-65: 231: 45.39
+	Dd
		710120 RACB_DICDI (31-220): 5.71e-87: 257: 48.69		PAKC_DICDI (394-675): 1e-63: 220: 41.96
+	Hs
		1026182 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Hs
		277609 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		PAK3_HUMAN (3-215): 8.38e-34: 138: 14.78
+	Hs
		1026925 RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63
+	Hs
		950963 RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Hs
		1026207 RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Mm
		103566 RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23		G5E884_MOUSE (3-205): 2.63e-39: 154: 17.16
+	Mm
		292040 RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23		PAK1_MOUSE (3-205): 7.18e-39: 153: 16.67
+	Hs
		950964 RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63
+	Hs
		1026939 RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63
+	Hs
		277602 RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23		PAK3_HUMAN (3-215): 8.38e-34: 138: 14.78
+	Mm
		925809 RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23		PAK2_MOUSE (9-162): 9.08e-34: 137: 19.26