HitPredict

Interactor 1: VP26B (Q8C0E2)
Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)
Gene: Vps26b

Interactor 2: VPS35 (Q9EQH3)
Vacuolar protein sorting-associated protein 35 (Maternal-embryonic 3) (Vesicle protein sorting 35)
Gene: VPS35

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.759

Property	Details
Experiments	18656452, 21040701
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Vps26~Vps35
Common GO terms	GO:0005769 - early endosome GO:0005770 - late endosome GO:0005829 - cytosol GO:0030904 - retromer complex GO:0042147 - retrograde transport, endosome to Golgi and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 336 Mm			1 796
+	Hs
		1194113 VP26B_HUMAN (1-336): 0: 523: 99.11		VPS35_HUMAN (1-796): 0: 1185: 99.37
+	Mm
		822492 VP26A_MOUSE (1-326): 6.01e-168: 472: 69.21		VPS35_MOUSE (1-796): 0: 1190: 100.00
+	Rn
		108185 VP26A_RAT (1-326): 4.97e-167: 469: 69.21		G3V8A5_RAT (1-796): 0: 1187: 99.75
+	Hs
		281777 VP26A_HUMAN (1-326): 2.19e-167: 470: 69.51		VPS35_HUMAN (1-796): 0: 1185: 99.37
+	At
		99943 VP26B_ARATH (1-297): 2.38e-151: 429: 54.67		VP35B_ARATH (10-796): 0: 1086: 42.93
+	Dm
		1489728 VPS26_DROME (1-300): 3.61e-159: 455: 73.00		Q9W277_DROME (10-786): 0: 1058: 61.87
+	At
		99941 VP26A_ARATH (1-298): 2.39e-148: 421: 53.82		VP35B_ARATH (10-796): 0: 1086: 42.93
+	At
		1274676 VP26A_ARATH (1-298): 2.39e-148: 421: 53.82		VP35A_ARATH (10-796): 0: 1047: 43.13
+	Hs
		71788 A8MY26_HUMAN (152-277): 1.92e-48: 162: 21.43		VPS35_HUMAN (1-796): 0: 1185: 99.37
+	Sc
		757379 PEP8_YEAST (1-296): 5.18e-111: 329: 34.47		VPS35_YEAST (17-766): 0: 754: 31.68