HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: RAB3C (P62823)
Ras-related protein Rab-3C
Gene: RAB3C

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	27507650, 28706196, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 227
+	Hs
		914291 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RB11A_HUMAN (20-227): 4.3e-99: 288: 35.85
+	Mm
		99942 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		RAB1A_MOUSE (20-227): 5.99e-93: 272: 43.75
+	Hs
		1289059 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RAB3C_HUMAN (1-227): 8.06e-95: 278: 97.36
+	Hs
		918932 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RAB1A_HUMAN (20-227): 5.99e-93: 272: 43.75
+	Mm
		99946 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		RAB3A_MOUSE (9-227): 2.43e-88: 261: 82.73
+	Hs
		591487 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RAB3A_HUMAN (9-227): 3.93e-88: 261: 82.73
+	Hs
		591660 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RAB3B_HUMAN (9-227): 4.36e-87: 258: 80.37
+	Mm
		99936 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		RAB10_MOUSE (23-194): 4.97e-63: 196: 52.91
+	Hs
		895541 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RAB10_HUMAN (23-194): 4.97e-63: 196: 52.91
+	Hs
		914440 NGAP_HUMAN (84-1338): 0: 800: 43.48		RB11A_HUMAN (20-227): 4.3e-99: 288: 35.85
+	Mm
		926075 GAPD1_MOUSE (412-1068): 7.48e-131: 440: 13.18		RAB3A_MOUSE (9-227): 2.43e-88: 261: 82.73