HitPredict

Interactor 1: CEP63 (Q96MT8)
Centrosomal protein of 63 kDa (Cep63)
Gene: CEP63

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.50	0.576

Property	Details
Experiments	17043677, unassigned1973, 35709258
Identification Methods	two hybrid, two hybrid fragment pooling approach, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 703 Hs			1 7388
+	Hs
		725073 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		110636 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		H3BPE1_HUMAN (66-7004): 0: 1955: 82.41
+	Mm
		513799 DEUP1_MOUSE (8-523): 3.71e-62: 220: 27.78		DMD_MOUSE (69-1516): 9.33e-77: 290: 18.75
+	Hs
		1068639 CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		1244124 CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00		SYNE1_HUMAN (343-1742): 3.05e-13: 80.2: 8.97
+	Hs
		974132 CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164656 CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		963396 CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		1045489 CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		93570 MYH9_MOUSE (1-520): 1.09e-21: 102: 11.22		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Hs
		724839 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		148330 CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29		SPTB1_HUMAN (3013-4737): 1.1e-28: 131: 8.92
+	Hs
		1068548 GRDN_HUMAN (150-697): 6.94e-17: 87.5: 12.91		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		724786 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164575 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		724781 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521484 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		724817 MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		148142 CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		148339 CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07