Protein: RTKN
Rhotekin

Gene: RTKN
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q9BST9

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000915 - actomyosin contractile ring assembly
GO:0005095 - GTPase inhibitor activity
GO:0005525 - GTP binding
GO:0005826 - actomyosin contractile ring

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962429

RHOA
Transforming protein RhoA

18

7

Small-scale

0.985

High

466435

RHOC
Rho-related GTP-binding protein RhoC

2

7

High-throughput

0.811

High

978259

RHOB
Rho-related GTP-binding protein RhoB

2

7

Small-scale

0.768

High

250324

VINEX
Vinexin

1

3

Small-scale

0.700

High

1360891

ACO11
Acyl-coenzyme A thioesterase 11

1

0

High-throughput

0.656

High

1086382

AKP13
A-kinase anchor protein 13

1

1

Small-scale

0.647

High

730202

1433B
14-3-3 protein beta/alpha

2

5

High-throughput

0.628

High

246124

KIF1B
Kinesin-like protein KIF1B

1

2

High-throughput

0.618

High

988661

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

Small-scale

0.618

High

1065758

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

1

High-throughput

0.618

High

1092484

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.618

High

1216088

SPD2A
SH3 and PX domain-containing protein 2A

1

2

High-throughput

0.618

High

1234930

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.618

High

1412880

PKHA5
Pleckstrin homology domain-containing family A member 5

1

3

High-throughput

0.618

High

1412882

KI13B
Kinesin-like protein KIF13B

1

2

High-throughput

0.618

High

1412895

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.618

High

1412897

STA13
StAR-related lipid transfer protein 13

1

1

High-throughput

0.618

High

167528

TX1B3
Tax1-binding protein 3

2

2

High-throughput

0.601

High

269607

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.586

High

1025589

CDK16
Cyclin-dependent kinase 16

1

0

High-throughput

0.586

High

1129978

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.586

High

1216024

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.586

High

1286538

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.586

High

1309245

KSR1
Kinase suppressor of Ras 1

1

0

High-throughput

0.586

High

1322641

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.586

High

1412894

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.586

High

1412876

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.578

High

1049723

1433F
14-3-3 protein eta

1

5

High-throughput

0.554

High

230565

KIF1C
Kinesin-like protein KIF1C

1

2

High-throughput

0.553

High

1352633

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

3

High-throughput

0.553

High

1412878

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.553

High

691380

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

867387

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

966819

1433G
14-3-3 protein gamma

1

5

High-throughput

0.536

High

990675

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.536

High

176876

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.517

High

245268

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

0

High-throughput

0.517

High

1293241

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

0

High-throughput

0.517

High

1402213

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.517

High

1412898

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

0

High-throughput

0.513

High

296820

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

948580

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

971942

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

1132530

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.513

High

1383832

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1403188

AEDO
2-aminoethanethiol dioxygenase

1

0

High-throughput

0.513

High

1410274

KLDC3
Kelch domain-containing protein 3

1

0

High-throughput

0.513

High

1412755

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

423015

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1412877

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

Small-scale

0.480

High

173292

XPO1
Exportin-1

1

1

High-throughput

0.479

High

281405

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.479

High

637946

NF1
Neurofibromin

1

1

High-throughput

0.479

High

719263

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719368

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

941051

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

1219616

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.479

High

1251424

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

1257038

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.479

High

1277707

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.479

High

1349475

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1352606

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1356762

HDAC7
Histone deacetylase 7

1

1

High-throughput

0.479

High

1401109

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.479

High

1410254

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1412889

XPO7
Exportin-7

1

1

High-throughput

0.479

High

1412890

NGAP
Ras GTPase-activating protein nGAP

1

1

High-throughput

0.479

High

252156

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

339104

NADK
NAD kinase

1

0

High-throughput

0.458

High

487694

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

1114152

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1245719

LARP1
La-related protein 1

1

0

High-throughput

0.458

High

1272879

RFIP2
Rab11 family-interacting protein 2

1

0

High-throughput

0.458

High

1350434

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1367147

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1409780

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1412875

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

1412879

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1412883

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1412887

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1412888

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

1412891

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1412892

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1412893

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

1412896

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1090177

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

High-throughput

0.437

High

1152033

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.437

High

1229902

AN34A
Ankyrin repeat domain-containing protein 34A

1

1

High-throughput

0.437

High

1338105

NAV1
Neuron navigator 1

1

1

High-throughput

0.437

High

1357416

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.437

High

261548

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

342656

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

1324452

CLASR
CLK4-associating serine/arginine rich protein

1

0

High-throughput

0.279

Low

1412873

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.279

Low

1412874

TR61B
tRNA

1

0

High-throughput

0.279

Low

1259236

TLC3B
Ceramide synthase

1

0

High-throughput

0.269

Low

208730

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.249

Low

294261

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

589554

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696361

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769033

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1134048

ZN638
Zinc finger protein 638

1

0

High-throughput

0.249

Low

1360399

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.249

Low

1410845

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

1412881

TANC2
Protein TANC2

1

0

High-throughput

0.249

Low

1412884

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1412885

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1412886

CING
Cingulin

1

0

High-throughput

0.249

Low

1412899

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low

1185868

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025