HitPredict

Interactor 1: MEIS1 (O00470)
Homeobox protein Meis1
Gene: MEIS1

Interactor 2: LMX1B (O60663)
LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)
Gene: LMX1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 390 Hs			1 402
+	Hs
		154457 MEIS2_HUMAN (1-385): 2.83e-116: 348: 80.81		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		238116 PKNX2_HUMAN (1-376): 8.49e-80: 254: 35.47		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		238102 PBX3_HUMAN (6-390): 8.78e-52: 180: 15.71		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Hs
		1251444 MEIS3_HUMAN (1-390): 1.47e-116: 345: 61.91		LMO3_HUMAN (53-171): 8.74e-26: 103: 40.32
+	Hs
		238101 PBX2_HUMAN (273-372): 1.59e-28: 117: 34.19		LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00
+	Dm
		773239 EXD_DROME (223-388): 2.81e-39: 146: 24.85		Q9VJ37_DROME (49-388): 2.14e-50: 179: 23.90
+	Ce
		447572 UNC62_CAEEL (189-383): 6e-26: 111: 35.78		MEC3_CAEEL (47-291): 1.81e-55: 187: 25.73
+	Ce
		589698 UNC62_CAEEL (189-383): 6e-26: 111: 35.78		LIN11_CAEEL (1-114): 5.74e-16: 80.8: 16.95