Protein: PFKAL
ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)

Gene: PFKAL, PFKL
Organism: Homo sapiens
Interactions: 175
UniProt ID: P17858

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005829 - cytosol
GO:0005945 - 6-phosphofructokinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

608865

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

3

14

High-throughput

0.861

High

608820

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

2

14

Small-scale

0.793

High

467869

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

2

14

Small-scale

0.757

High

345344

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

0

High-throughput

0.613

High

563147

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.601

High

240692

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

362732

EGFR
Epidermal growth factor receptor

2

7

High-throughput

0.584

High

608825

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.573

High

608828

KRA59
Keratin-associated protein 5-9

1

2

High-throughput

0.573

High

608856

KR107
Keratin-associated protein 10-7

1

1

High-throughput

0.573

High

395451

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

608889

CE162
Centrosomal protein of 162 kDa

2

3

High-throughput

0.571

High

608896

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.571

High

608928

KR412
Keratin-associated protein 4-12

1

1

High-throughput

0.541

High

608932

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.541

High

608901

DAAF5
Dynein axonemal assembly factor 5

1

0

Small-scale

0.537

High

161941

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

6

High-throughput

0.536

High

389001

FINC
Fibronectin

1

1

High-throughput

0.536

High

608846

GRK6
G protein-coupled receptor kinase 6

1

5

High-throughput

0.536

High

608852

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.536

High

608867

TIE2
Angiopoietin-1 receptor

1

10

High-throughput

0.536

High

608902

FOXP4
Forkhead box protein P4

1

2

High-throughput

0.536

High

608918

FAF2
FAS-associated factor 2

1

1

High-throughput

0.536

High

608931

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

608934

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

2

High-throughput

0.536

High

608882

TESK1
Dual specificity testis-specific protein kinase 1

1

0

High-throughput

0.518

High

608897

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

608927

MYD88
Myeloid differentiation primary response protein MyD88

1

0

High-throughput

0.518

High

188811

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.515

High

459218

CATL1
Procathepsin L

1

3

High-throughput

0.515

High

460768

CATB
Cathepsin B

1

5

High-throughput

0.515

High

488716

FURIN
Furin

1

1

High-throughput

0.515

High

608827

CATS
Cathepsin S

1

3

High-throughput

0.515

High

608831

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

608899

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.515

High

608909

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.515

High

608945

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.515

High

608950

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.515

High

608886

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

0

High-throughput

0.513

High

608903

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

608908

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

608925

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

608930

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

608944

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

608887

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

4

Small-scale

0.512

High

280494

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.508

High

608830

1433T
14-3-3 protein theta

1

6

High-throughput

0.501

High

410600

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

7

High-throughput

0.500

High

608833

EPHA8
Ephrin type-A receptor 8

1

7

High-throughput

0.500

High

608874

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.489

High

421461

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

129986

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

156934

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

164243

NRP1
Neuropilin-1

1

2

High-throughput

0.479

High

222702

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

238380

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

325678

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

379865

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

411315

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

439940

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.479

High

477204

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

13

High-throughput

0.479

High

536456

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

560301

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

565133

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

608821

VGFR1
Vascular endothelial growth factor receptor 1

1

11

High-throughput

0.479

High

608823

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

608824

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.479

High

608826

FGFR3
Fibroblast growth factor receptor 3

1

18

High-throughput

0.479

High

608829

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

608834

PML
Protein PML

1

2

High-throughput

0.479

High

608835

UFO
Tyrosine-protein kinase receptor UFO

1

12

High-throughput

0.479

High

608837

BASI
Basigin

1

1

High-throughput

0.479

High

608839

VGFR3
Vascular endothelial growth factor receptor 3

1

11

High-throughput

0.479

High

608840

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

10

High-throughput

0.479

High

608843

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

608844

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

3

High-throughput

0.479

High

608847

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

608848

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

608851

CDK9
Cyclin-dependent kinase 9

1

10

High-throughput

0.479

High

608853

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.479

High

608860

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

608861

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

608862

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

2

High-throughput

0.479

High

608863

RELB
Transcription factor RelB

1

2

High-throughput

0.479

High

608866

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

608868

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

608871

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.479

High

608873

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

608875

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

608876

CUL7
Cullin-7

1

1

High-throughput

0.479

High

608878

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

608879

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

608885

DDR2
Discoidin domain-containing receptor 2

1

12

High-throughput

0.479

High

608891

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

608892

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

608893

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

608900

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

608906

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

608907

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

608910

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

608914

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

608919

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.479

High

608920

AURKB
Aurora kinase B

1

7

High-throughput

0.479

High

608922

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

608923

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

608926

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

3

High-throughput

0.479

High

608929

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.479

High

608933

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

608937

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

608940

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

608942

ANLN
Anillin

1

1

High-throughput

0.479

High

608943

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

608947

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

608948

HDAC6
Protein deacetylase HDAC6

1

5

Small-scale

0.479

High

608949

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

608953

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

608854

ATN1
Atrophin-1

1

1

High-throughput

0.464

High

553114

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

590786

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

608842

COIL
Coilin

1

0

High-throughput

0.458

High

608857

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

608884

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

608894

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

608917

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

608938

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

608946

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.458

High

608858

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.457

High

95944

E7ET36
Transferrin receptor 2

1

1

High-throughput

0.445

High

397891

ANGI
Angiogenin

1

1

High-throughput

0.445

High

529030

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

608822

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.445

High

608855

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

608888

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

608935

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

608952

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

105288

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

352319

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

371105

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

587870

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

608832

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

608836

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

608841

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.437

High

608859

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

608864

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

608869

DMWD
Dystrophia myotonica WD repeat-containing protein

1

5

High-throughput

0.437

High

608877

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

Small-scale

0.437

High

608881

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

608883

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

608895

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

608898

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

608905

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

608911

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

608912

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.437

High

608916

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

608924

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.437

High

608936

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

608939

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

608941

SHCAF
SIN3-HDAC complex-associated factor

1

1

Small-scale

0.437

High

608951

TFR2
Transferrin receptor protein 2

1

1

High-throughput

0.437

High

608845

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

608850

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

608870

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.407

High

608904

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

608915

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

0

High-throughput

0.299

High

193982

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

227361

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

247659

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

608838

FUS
RNA-binding protein FUS

1

0

High-throughput

0.249

Low

608849

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

608872

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.249

Low

608880

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.249

Low

608890

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

608913

DPF3
Zinc finger protein DPF3

1

0

Small-scale

0.249

Low

608921

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025