Protein: PFKAP
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)

Gene: PFKAP, PFKP
Organism: Homo sapiens
Interactions: 227
UniProt ID: Q01813

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

467897

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

7

14

Small-scale

0.956

High

608865

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

3

14

High-throughput

0.861

High

1032453

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

2

14

Small-scale

0.794

High

363146

EGFR
Epidermal growth factor receptor

3

7

Small-scale

0.664

High

724677

MK04
Mitogen-activated protein kinase 4

2

12

High-throughput

0.628

High

965543

NTF2
Nuclear transport factor 2

2

2

High-throughput

0.606

High

1032517

NELL1
Protein kinase C-binding protein NELL1

2

0

High-throughput

0.602

High

529654

TAU
Microtubule-associated protein tau

2

10

High-throughput

0.601

High

411759

NTRK1
High affinity nerve growth factor receptor

2

14

High-throughput

0.594

High

241431

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

371797

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

536994

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

1032454

MECOM
Histone-lysine N-methyltransferase MECOM

2

3

High-throughput

0.584

High

1032469

DX39B
Spliceosome RNA helicase DDX39B

2

2

Small-scale

0.584

High

1032536

ACE2
Angiotensin-converting enzyme 2

2

2

Small-scale

0.584

High

1032558

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

728180

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.578

High

395935

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

1032494

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.571

High

699699

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.561

High

623286

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.554

High

928420

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.552

High

1032483

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

1032544

WNK1
Serine/threonine-protein kinase WNK1

1

6

High-throughput

0.541

High

1032561

AGO2
Protein argonaute-2

1

1

High-throughput

0.541

High

389304

FINC
Fibronectin

1

1

High-throughput

0.536

High

400675

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.536

High

690916

1433T
14-3-3 protein theta

1

6

High-throughput

0.536

High

765407

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

846739

GRK6
G protein-coupled receptor kinase 6

1

5

High-throughput

0.536

High

872215

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

966203

1433G
14-3-3 protein gamma

1

6

High-throughput

0.536

High

1032455

KPCZ
Protein kinase C zeta type

1

3

High-throughput

0.536

High

1032457

DMWD
Dystrophia myotonica WD repeat-containing protein

1

5

High-throughput

0.536

High

1032462

ILK
Scaffold protein ILK

1

3

High-throughput

0.536

High

1032466

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1032467

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1032488

PKN3
Serine/threonine-protein kinase N3

1

3

High-throughput

0.536

High

1032508

HIPK4
Homeodomain-interacting protein kinase 4

1

10

High-throughput

0.536

High

1032509

WDR19
WD repeat-containing protein 19

1

3

High-throughput

0.536

High

1032518

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

1032530

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1032538

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

2

High-throughput

0.536

High

1032548

IF122
Intraflagellar transport protein 122 homolog

1

4

High-throughput

0.536

High

1032572

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

7

High-throughput

0.536

High

105775

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

1032521

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.529

High

188864

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.515

High

352405

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.515

High

459271

CATL1
Procathepsin L

1

3

High-throughput

0.515

High

460803

CATB
Cathepsin B

1

5

High-throughput

0.515

High

488774

FURIN
Furin

1

1

High-throughput

0.515

High

580616

AMPN
Aminopeptidase N

1

2

High-throughput

0.515

High

659448

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.515

High

692932

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

774295

BASI
Basigin

1

1

High-throughput

0.515

High

830587

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

1032496

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.515

High

1032513

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.515

High

1032555

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.515

High

1032562

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.515

High

1032498

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

964228

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

410777

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

7

High-throughput

0.500

High

439703

INSR
Insulin receptor

1

14

High-throughput

0.500

High

465489

IGF1R
Insulin-like growth factor 1 receptor

1

15

High-throughput

0.500

High

484107

PGFRB
Platelet-derived growth factor receptor beta

1

16

High-throughput

0.500

High

541442

FGFR1
Fibroblast growth factor receptor 1

1

18

High-throughput

0.500

High

641157

FGFR2
Fibroblast growth factor receptor 2

1

19

High-throughput

0.500

High

648487

FGFR4
Fibroblast growth factor receptor 4

1

18

High-throughput

0.500

High

710699

EPHA8
Ephrin type-A receptor 8

1

7

High-throughput

0.500

High

777671

VGFR3
Vascular endothelial growth factor receptor 3

1

11

High-throughput

0.500

High

1032456

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

13

High-throughput

0.500

High

1032478

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.500

High

1032487

STYK1
Tyrosine-protein kinase STYK1

1

5

High-throughput

0.500

High

1032491

LMTK1
Serine/threonine-protein kinase LMTK1

1

18

High-throughput

0.500

High

1032511

SP7
Transcription factor Sp7

1

1

High-throughput

0.500

High

1032563

ALK
ALK tyrosine kinase receptor

1

13

High-throughput

0.500

High

1032524

FAF2
FAS-associated factor 2

1

1

High-throughput

0.489

High

1032519

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.480

High

1032535

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.479

High

130073

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

157257

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

159611

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

164316

NRP1
Neuropilin-1

1

2

High-throughput

0.479

High

259814

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

294854

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

3

High-throughput

0.479

High

334547

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

380006

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

440031

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.479

High

472041

MET
Hepatocyte growth factor receptor

1

8

High-throughput

0.479

High

507852

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

521315

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.479

High

560367

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

565352

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

588493

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

609988

VGFR1
Vascular endothelial growth factor receptor 1

1

11

High-throughput

0.479

High

630252

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

695242

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

728579

AKT2
RAC-beta serine/threonine-protein kinase

1

3

Small-scale

0.479

High

799005

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

862050

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

883221

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

887984

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

907385

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

910016

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

919894

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.479

High

952113

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.479

High

955070

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

959566

MAX
Protein max

1

4

High-throughput

0.479

High

961964

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

970357

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

977944

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

984079

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

984721

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

988291

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

990111

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

1032459

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.479

High

1032461

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1032464

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1032468

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.479

High

1032471

CUL7
Cullin-7

1

1

High-throughput

0.479

High

1032472

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

Small-scale

0.479

High

1032473

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

1032474

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1032475

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1032476

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.479

High

1032477

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1032480

DUS6
Dual specificity protein phosphatase 6

1

2

High-throughput

0.479

High

1032484

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1032485

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

1032486

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1032493

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1032497

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

Small-scale

0.479

High

1032500

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1032501

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

1032506

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.479

High

1032507

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1032510

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

1032512

PARD3
Partitioning defective 3 homolog

1

3

Small-scale

0.479

High

1032514

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1032515

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1032516

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.479

High

1032520

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1032523

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

1032525

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

1032526

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1032527

MIA2
Melanoma inhibitory activity protein 2

1

4

High-throughput

0.479

High

1032528

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1032529

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

1032531

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1032540

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

1032541

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

1032543

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1032545

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.479

High

1032546

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1032547

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

1032549

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

1032550

SHCAF
SIN3-HDAC complex-associated factor

1

1

Small-scale

0.479

High

1032551

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1032552

ANLN
Anillin

1

1

High-throughput

0.479

High

1032554

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

1032559

HDAC6
Protein deacetylase HDAC6

1

5

Small-scale

0.479

High

1032560

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

1032565

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

Small-scale

0.479

High

1032570

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

1032571

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

822618

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

166900

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

190876

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

293581

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

420498

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

472296

CFAH
Complement factor H

1

0

Small-scale

0.458

High

521648

H14
Histone H1.4

1

0

High-throughput

0.458

High

555379

SKI
Ski oncogene

1

0

Small-scale

0.458

High

555664

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.458

High

556021

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

664715

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

681342

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.458

High

948791

CD81
CD81 antigen

1

0

High-throughput

0.458

High

974990

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1032460

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

1032463

GAB1
GRB2-associated-binding protein 1

1

0

Small-scale

0.458

High

1032465

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

Small-scale

0.458

High

1032470

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1032479

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

1032481

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1032482

FBX43
F-box only protein 43

1

0

Small-scale

0.458

High

1032489

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1032492

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.458

High

1032495

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1032499

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1032504

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.458

High

1032505

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.458

High

1032532

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1032534

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

1032542

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1032553

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1032557

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1032564

SNX6
Sorting nexin-6

1

0

High-throughput

0.458

High

1032568

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

1032569

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

397940

ANGI
Angiogenin

1

1

High-throughput

0.445

High

563637

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

619748

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.445

High

626185

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.445

High

1032458

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.445

High

1032503

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

1032539

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1032566

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

1032567

ST38L
Serine/threonine-protein kinase 38-like

1

4

High-throughput

0.445

High

228703

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

6

High-throughput

0.437

High

680692

CATS
Cathepsin S

1

3

High-throughput

0.437

High

767984

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1031342

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

1032522

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

1032537

RHBT2
Rho-related BTB domain-containing protein 2

1

9

High-throughput

0.437

High

218070

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.298

High

1032533

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.288

High

1032556

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

276113

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

353257

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1032490

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1032502

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1032573

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.249

Low

1015

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025