HitPredict

Interactor 1: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Interactor 2: KS6B2 (Q9UBS0)
Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta)
Gene: RPS6KB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 975 Hs			1 482
+	Hs
		1299664 NED4L_HUMAN (1-975): 0: 1033: 100.00		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		681988 NED4L_HUMAN (1-975): 0: 1033: 100.00		AKT1_HUMAN (5-391): 6.01e-153: 445: 39.19
+	Hs
		117024 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK1_HUMAN (55-393): 4e-100: 308: 47.03
+	Hs
		1285839 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK3_HUMAN (46-393): 3.33e-94: 295: 45.00
+	Mm
		1208292 NED4L_MOUSE (17-975): 0: 1014: 98.02		SGK1_MOUSE (28-392): 3.09e-100: 309: 44.73
+	Xl
		1151478 Q6GMD5_XENLA (7-975): 0: 1003: 89.69		SGK1A_XENLA (55-392): 3.81e-100: 309: 47.01
+	Hs
		616684 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6B1_HUMAN (1-476): 3.36e-173: 499: 68.58
+	Hs
		568765 ITCH_HUMAN (9-972): 0: 772: 33.16		KAPCA_HUMAN (31-387): 1.3e-144: 419: 34.17
+	Mm
		93288 E9PXB7_MOUSE (122-975): 0: 863: 95.79		SGK1_MOUSE (28-392): 3.09e-100: 309: 44.73
+	Hs
		808324 NEDD4_HUMAN (94-975): 0: 724: 49.78		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		681731 NEDD4_HUMAN (94-975): 0: 724: 49.78		AKT1_HUMAN (5-391): 6.01e-153: 445: 39.19
+	Hs
		1285838 ITCH_HUMAN (9-972): 0: 772: 33.16		SGK3_HUMAN (46-393): 3.33e-94: 295: 45.00
+	Hs
		808054 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6A3_HUMAN (5-380): 2.45e-105: 331: 26.85
+	Hs
		116984 NEDD4_HUMAN (94-975): 0: 724: 49.78		SGK1_HUMAN (55-393): 4e-100: 308: 47.03
+	Hs
		272855 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07
+	Hs
		566484 SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71		KPCA_HUMAN (9-401): 2.4e-148: 440: 35.82
+	Hs
		272906 HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07