HitPredict

Interactor 1: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 975 Hs			1 479
+	Hs
		681988 NED4L_HUMAN (1-975): 0: 1033: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		1285839 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		1299657 NED4L_HUMAN (1-975): 0: 1033: 100.00		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		117024 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		1299638 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Mm
		1208292 NED4L_MOUSE (17-975): 0: 1014: 98.02		SGK1_MOUSE (102-476): 8.59e-147: 428: 47.34
+	Xl
		1151478 Q6GMD5_XENLA (7-975): 0: 1003: 89.69		SGK1A_XENLA (99-476): 2.89e-148: 431: 45.38
+	Hs
		808324 NEDD4_HUMAN (94-975): 0: 724: 49.78		AKT3_HUMAN (1-479): 0: 589: 100.00
+	Mm
		93288 E9PXB7_MOUSE (122-975): 0: 863: 95.79		SGK1_MOUSE (102-476): 8.59e-147: 428: 47.34
+	Hs
		681731 NEDD4_HUMAN (94-975): 0: 724: 49.78		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		1285838 ITCH_HUMAN (9-972): 0: 772: 33.16		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		616684 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		116984 NEDD4_HUMAN (94-975): 0: 724: 49.78		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		808277 NEDD4_HUMAN (94-975): 0: 724: 49.78		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Hs
		808054 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		408640 HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		784035 HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94
+	Hs
		566484 SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		784093 SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94