Protein: VPS60
Vacuolar protein-sorting-associated protein 60 (Charged multivesicular body protein 5)

Gene: VPS60
Organism: Saccharomyces cerevisiae S288C
Interactions: 79
UniProt ID: Q03390

Gene Ontology (top 5):
GO:0000329 - fungal-type vacuole membrane
GO:0005737 - cytoplasm
GO:0005771 - multivesicular body
GO:0006900 - vesicle budding from membrane
GO:0010008 - endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042558

VTA1
Vacuolar protein sorting-associated protein VTA1

10

1

Small-scale

0.977

High

815055

SNF7
Vacuolar-sorting protein SNF7

6

18

Small-scale

0.946

High

781017

VPS24
Vacuolar protein-sorting-associated protein 24

3

20

Small-scale

0.857

High

999492

DID2
Vacuolar protein-sorting-associated protein 46

3

20

Small-scale

0.827

High

781335

DID4
DOA4-independent degradation protein 4

2

20

Small-scale

0.806

High

1042553

VPS60
Vacuolar protein-sorting-associated protein 60

2

18

Small-scale

0.793

High

923807

IST1
Vacuolar protein sorting-associated protein IST1

2

11

Small-scale

0.754

High

1042554

VPS20
Vacuolar protein sorting-associated protein 20

2

18

Small-scale

0.754

High

546065

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

Small-scale

0.571

High

963683

H3
Histone H3

2

3

Small-scale

0.533

High

750767

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.515

High

692427

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.501

High

477622

MYO1
Myosin-1

1

7

High-throughput

0.481

High

735664

SMY1
Kinesin-related protein SMY1

1

3

High-throughput

0.481

High

753133

NIP80
Protein NIP100

1

6

High-throughput

0.481

High

809224

END3
Actin cytoskeleton-regulatory complex protein END3

1

2

High-throughput

0.481

High

815661

LIS1
Nuclear distribution protein PAC1

1

8

High-throughput

0.481

High

924895

AF9
Protein AF-9 homolog

1

1

High-throughput

0.481

High

364715

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.479

High

435320

RS3
Small ribosomal subunit protein uS3

1

3

Small-scale

0.479

High

656600

KC11
Casein kinase I homolog 1

1

7

Small-scale

0.479

High

656853

KC12
Casein kinase I homolog 2

1

7

Small-scale

0.479

High

739843

MSS1
tRNA modification GTPase MSS1, mitochondrial

1

4

Small-scale

0.479

High

742935

HSP79
Heat shock protein homolog SSE2

1

11

Small-scale

0.479

High

747096

PTR2
Peptide transporter PTR2

1

7

Small-scale

0.479

High

817110

YAT2
Carnitine O-acetyltransferase YAT2

1

1

Small-scale

0.479

High

823081

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

3

Small-scale

0.479

High

865451

VPS55
Vacuolar protein sorting-associated protein 55

1

1

Small-scale

0.479

High

919248

YG3A
Uncharacterized protein YGR130C

1

14

Small-scale

0.479

High

1042561

NEW1
[NU+] prion formation protein 1

1

3

Small-scale

0.479

High

1042562

VPS68
Vacuolar protein sorting-associated protein 68

1

1

Small-scale

0.479

High

1042563

TMS1
Membrane protein TMS1

1

2

Small-scale

0.479

High

1042565

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.479

High

755287

NUF2
Kinetochore protein NUF2

1

3

High-throughput

0.470

High

664344

SSD1
Protein SSD1

1

0

High-throughput

0.460

High

416473

HXKA
Hexokinase-1

1

0

Small-scale

0.458

High

726589

VATC
V-type proton ATPase subunit C

1

0

Small-scale

0.458

High

735440

TREA
Cytosolic neutral trehalase

1

0

Small-scale

0.458

High

739091

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

0

Small-scale

0.458

High

782279

YK55
Uncharacterized protein YKR075C

1

0

Small-scale

0.458

High

796824

EXO84
Exocyst complex component EXO84

1

0

Small-scale

0.458

High

806992

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

Small-scale

0.458

High

924418

CBK1
Serine/threonine-protein kinase CBK1

1

0

Small-scale

0.458

High

1026965

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

Small-scale

0.458

High

1042559

HBT1
Protein HBT1

1

0

Small-scale

0.458

High

1042566

ATC4
Phospholipid-transporting ATPase DNF2

1

0

Small-scale

0.458

High

524975

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

527541

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

804413

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

737030

CDC3
Cell division control protein 3

1

1

High-throughput

0.439

High

777107

BDF1
Bromodomain-containing factor 1

1

5

High-throughput

0.439

High

804913

LAM4
Membrane-anchored lipid-binding protein LAM4

1

1

High-throughput

0.439

High

1042560

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

1

High-throughput

0.439

High

359521

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

Small-scale

0.437

High

399877

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

Small-scale

0.437

High

420979

PMA1
Plasma membrane ATPase 1

1

3

Small-scale

0.437

High

680010

CDC48
Cell division control protein 48

1

6

High-throughput

0.437

High

708017

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

734383

OAC1
Mitochondrial oxaloacetate transport protein

1

5

Small-scale

0.437

High

737246

HXT1
Low-affinity glucose transporter HXT1

1

2

Small-scale

0.437

High

780885

STB6
Protein STB6

1

2

Small-scale

0.437

High

801103

FKS1
1,3-beta-glucan synthase component FKS1

1

1

Small-scale

0.437

High

805497

TOM71
Protein TOM71

1

3

Small-scale

0.437

High

817503

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

1

Small-scale

0.437

High

822015

PSA4
Proteasome subunit alpha type-4

1

4

Small-scale

0.437

High

865582

ARP3
Actin-related protein 3

1

6

Small-scale

0.437

High

902669

RL9B
Large ribosomal subunit protein uL6B

1

1

Small-scale

0.437

High

925480

EF3B
Elongation factor 3B

1

3

Small-scale

0.437

High

1042564

BAG7
Rho-GTPase-activating protein BAG7

1

2

Small-scale

0.437

High

871556

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

1042555

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.269

Low

439163

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

Small-scale

0.249

Low

454231

LEUC
3-isopropylmalate dehydratase

1

0

Small-scale

0.249

Low

814125

HPH2
Protein HPH2

1

0

Small-scale

0.249

Low

863589

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

Small-scale

0.249

Low

1017956

TIM10
Mitochondrial import inner membrane translocase subunit TIM10

1

0

Small-scale

0.249

Low

1042556

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

Small-scale

0.249

Low

1042557

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025