HitPredict

Interactor 1: MEIS1 (O00470)
Homeobox protein Meis1
Gene: MEIS1

Interactor 2: HME1 (Q05925)
Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)
Gene: EN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 392
+	Mm
		1141918 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXA13_MOUSE (139-360): 3.8e-32: 126: 21.74
+	Mm
		488048 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXB4_MOUSE (254-367): 5.02e-33: 125: 33.33
+	Hs
		129972 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		EMX2_HUMAN (156-391): 2.59e-32: 123: 24.79
+	Mm
		446924 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXA5_MOUSE (114-368): 3.19e-29: 116: 21.18
+	Mm
		936326 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXD13_MOUSE (121-360): 1.5e-28: 115: 16.74
+	Mm
		679059 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXA11_MOUSE (89-365): 3.2e-27: 111: 18.12
+	Mm
		956310 MEIS2_MOUSE (1-385): 7e-117: 350: 80.81		HXA13_MOUSE (139-360): 3.8e-32: 126: 21.74
+	Mm
		956309 MEIS2_MOUSE (1-385): 7e-117: 350: 80.81		EMX1_MOUSE (184-389): 1.95e-32: 124: 26.07
+	Mm
		956313 MEIS3_MOUSE (1-390): 4.89e-115: 342: 62.66		HXA13_MOUSE (139-360): 3.8e-32: 126: 21.74
+	Dm
		221139 HTH_DROME (1-389): 3.2e-87: 274: 47.00		HMEN_DROME (221-391): 1.93e-32: 130: 50.58
+	Dm
		221160 HTH_DROME (1-389): 3.2e-87: 274: 47.00		UBX_DROME (180-361): 8.35e-29: 117: 20.67
+	Hs
		829802 PKNX1_HUMAN (13-379): 5.44e-82: 259: 35.08		HXA1_HUMAN (140-376): 1.7e-32: 126: 21.99
+	Hs
		174014 PKNX1_HUMAN (13-379): 5.44e-82: 259: 35.08		SHOX_HUMAN (292-364): 1.09e-28: 115: 34.25
+	Mm
		447608 PKNX2_MOUSE (1-376): 1.74e-80: 256: 35.47		HXA6_MOUSE (131-375): 2.6e-30: 118: 20.41
+	Mm
		192602 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXB5_MOUSE (200-366): 3.43e-32: 124: 25.15
+	Mm
		192610 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXC5_MOUSE (184-370): 1.54e-32: 123: 27.41
+	Mm
		192606 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXD4_MOUSE (178-367): 4.63e-31: 120: 25.26
+	Mm
		192607 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXC6_MOUSE (151-362): 9.2e-31: 119: 18.40
+	Mm
		192603 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXA6_MOUSE (131-375): 2.6e-30: 118: 20.41
+	Mm
		192609 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXD10_MOUSE (83-372): 2.54e-27: 112: 14.48