HitPredict

Interactor 1: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14968112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1091 Hs			1 1620
+	Hs
		1221833 SMC5_HUMAN (5-1069): 1.28e-69: 255: 16.18		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		725268 MYH10_HUMAN (472-979): 2.06e-21: 103: 10.92		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		725069 MYH9_HUMAN (588-990): 2.42e-19: 96.6: 12.90		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		311483 SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		311477 SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		311462 SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		311465 SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		311530 SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19		TIE2_HUMAN (954-1389): 7.66e-115: 393: 29.30
+	Hs
		385385 SMC6_HUMAN (1-1091): 2.11e-115: 385: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		609617 SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		445885 SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		665375 MYH9_HUMAN (588-990): 2.42e-19: 96.6: 12.90		EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87
+	Hs
		311459 SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		385736 SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		385587 SMC4_HUMAN (2-977): 1e-39: 162: 10.55		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		384210 DESP_HUMAN (126-744): 7.41e-23: 108: 8.27		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		384385 MYH10_HUMAN (472-979): 2.06e-21: 103: 10.92		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		426943 DESP_HUMAN (126-744): 7.41e-23: 108: 8.27		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80
+	Hs
		384384 MYH9_HUMAN (588-990): 2.42e-19: 96.6: 12.90		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07