Protein: ACVR1
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)

Gene: ACVR1
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q04771

Gene Ontology (top 5):
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001649 - osteoblast differentiation
GO:0001701 - in utero embryonic development
GO:0001702 - gastrulation with mouth forming second
GO:0001707 - mesoderm formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787152

BMR1A
Bone morphogenetic protein receptor type-1A

4

20

Small-scale

0.899

High

1048353

BMPR2
Bone morphogenetic protein receptor type-2

4

20

Small-scale

0.898

High

788457

ACVL1
Activin receptor type-1-like

3

19

High-throughput

0.861

High

787289

ACV1B
Activin receptor type-1B

3

19

Small-scale

0.847

High

611723

BMP7
Bone morphogenetic protein 7

2

20

Small-scale

0.778

High

690085

AVR2A
Activin receptor type-2A

2

20

Small-scale

0.754

High

986847

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

7

Small-scale

0.737

High

1048381

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

19

High-throughput

0.726

High

1048374

TGFA1
Transforming growth factor-beta receptor-associated protein 1

5

5

High-throughput

0.709

High

410788

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.691

High

440502

FYN
Tyrosine-protein kinase Fyn

1

5

High-throughput

0.691

High

572917

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

720197

UFO
Tyrosine-protein kinase receptor UFO

1

8

High-throughput

0.691

High

1048352

AVR2B
Activin receptor type-2B

1

20

High-throughput

0.691

High

1048377

ASTRA
Protein Aster-A

4

0

High-throughput

0.661

High

643194

BMP6
Bone morphogenetic protein 6

1

20

Small-scale

0.647

High

1048346

ACVR1
Activin receptor type-1

1

20

Small-scale

0.647

High

1048399

GDF2
Growth/differentiation factor 2

1

20

Small-scale

0.647

High

1048359

SMAD1
Mothers against decapentaplegic homolog 1

3

20

Small-scale

0.642

High

1048379

MRAP2
Melanocortin-2 receptor accessory protein 2

2

5

High-throughput

0.628

High

1048393

CD320
CD320 antigen

2

3

High-throughput

0.628

High

788904

TGFR2
TGF-beta receptor type-2

1

18

Small-scale

0.621

High

470368

INHBA
Inhibin beta A chain

1

20

Small-scale

0.618

High

845231

GDF5
Growth/differentiation factor 5

1

20

Small-scale

0.618

High

1048350

SQSTM
Sequestosome-1

1

4

Small-scale

0.618

High

1048397

EPHA6
Ephrin type-A receptor 6

1

15

Small-scale

0.618

High

1048370

RN149
E3 ubiquitin-protein ligase RNF149

3

11

High-throughput

0.609

High

1048407

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

6

High-throughput

0.601

High

787385

TGFR1
TGF-beta receptor type-1

1

19

High-throughput

0.590

High

219857

SMAD6
Mothers against decapentaplegic homolog 6

2

20

Small-scale

0.584

High

1048385

SMAD5
Mothers against decapentaplegic homolog 5

2

20

Small-scale

0.584

High

1048391

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

19

Small-scale

0.584

High

1048375

NECT2
Nectin-2

1

5

High-throughput

0.575

High

1048376

OSTF1
Osteoclast-stimulating factor 1

1

10

High-throughput

0.553

High

1048403

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.547

High

1048371

CCNY
Cyclin-Y

1

0

High-throughput

0.546

High

127669

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

8

High-throughput

0.536

High

163286

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

11

High-throughput

0.536

High

1048363

KCNKI
Potassium channel subfamily K member 18

1

5

High-throughput

0.536

High

1048382

OPALI
Opalin

1

3

High-throughput

0.536

High

1048384

MYADM
Myeloid-associated differentiation marker

1

1

High-throughput

0.536

High

1048400

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

4

High-throughput

0.536

High

1048361

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

2

High-throughput

0.514

High

1048398

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.514

High

1048402

DJC16
DnaJ homolog subfamily C member 16

1

1

High-throughput

0.514

High

561354

TDGF1
Protein Cripto

1

7

Small-scale

0.501

High

1048348

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.501

High

1048404

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

1048366

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

1048347

SRSF4
Serine/arginine-rich splicing factor 4

1

0

High-throughput

0.481

High

1048396

SACS
Sacsin

1

0

High-throughput

0.481

High

881654

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

1

Small-scale

0.481

High

138077

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

Small-scale

0.479

High

177671

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.479

High

608254

EGLN
Endoglin

1

12

Small-scale

0.479

High

1048351

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

1048358

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.479

High

1048360

DCAF6
DDB1- and CUL4-associated factor 6

1

5

High-throughput

0.479

High

1048362

RGMB
Repulsive guidance molecule B

1

6

Small-scale

0.479

High

1048364

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.479

High

1048369

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

1048401

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

1048405

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

Small-scale

0.479

High

1004475

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

731219

STIP1
Stress-induced-phosphoprotein 1

1

2

Small-scale

0.457

High

1048378

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.457

High

624630

SL9A1
Sodium/hydrogen exchanger 1

1

2

High-throughput

0.445

High

641942

CD9
CD9 antigen

1

4

High-throughput

0.445

High

839244

MTOR
Serine/threonine-protein kinase mTOR

1

3

High-throughput

0.445

High

907744

CLCN5
H(+)/Cl(-) exchange transporter 5

1

1

High-throughput

0.445

High

913128

STAT2
Signal transducer and activator of transcription 2

1

3

High-throughput

0.445

High

942485

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

2

High-throughput

0.445

High

1048349

STX5
Syntaxin-5

1

1

High-throughput

0.445

High

1048354

DOCK1
Dedicator of cytokinesis protein 1

1

2

High-throughput

0.445

High

1048365

EXOC8
Exocyst complex component 8

1

1

High-throughput

0.445

High

1048367

S39AB
Zinc transporter ZIP11

1

3

High-throughput

0.445

High

1048372

RAI3
Retinoic acid-induced protein 3

1

2

High-throughput

0.445

High

1048387

AP1M1
AP-1 complex subunit mu-1

1

1

High-throughput

0.445

High

1048389

DOCK5
Dedicator of cytokinesis protein 5

1

2

High-throughput

0.445

High

1048392

AT131
Endoplasmic reticulum transmembrane helix translocase

1

4

High-throughput

0.445

High

698598

CALX
Calnexin

1

7

High-throughput

0.437

High

282372

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.426

High

361693

F13A
Coagulation factor XIII A chain

1

0

High-throughput

0.426

High

602209

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.426

High

895346

S26A2
Sulfate transporter

1

0

High-throughput

0.426

High

1048356

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

High-throughput

0.426

High

994908

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

1

High-throughput

0.407

High

1006188

CNTP1
Contactin-associated protein 1

1

3

High-throughput

0.407

High

1048357

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.407

High

1048373

RHBL4
Rhomboid-related protein 4

1

6

High-throughput

0.407

High

1048406

SPCS1
Signal peptidase complex subunit 1

1

1

High-throughput

0.407

High

1048388

ARV1
Protein ARV1

3

0

High-throughput

0.347

High

60328

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.232

Low

1048355

ABRX2
BRISC complex subunit Abraxas 2

1

0

High-throughput

0.232

Low

1048368

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.232

Low

1048380

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.232

Low

1048383

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.232

Low

1048386

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.232

Low

1048390

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.232

Low

1048394

F1142
Protein FAM114A2

1

0

High-throughput

0.232

Low

1048395

TM160
Transmembrane protein 160

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025