Protein: IF5A1
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)

Gene: IF5A1, EIF5A
Organism: Homo sapiens
Interactions: 198
UniProt ID: P63241

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003746 - translation elongation factor activity
GO:0005634 - nucleus
GO:0005642 - annulate lamellae
GO:0005643 - nuclear pore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

929359

IF5A2
Eukaryotic translation initiation factor 5A-2

2

3

High-throughput

0.789

High

227121

PRKN
E3 ubiquitin-protein ligase parkin

4

3

High-throughput

0.686

High

826509

DHYS
Deoxyhypusine synthase

3

7

High-throughput

0.675

High

929285

REL
Proto-oncogene c-Rel

3

1

High-throughput

0.675

High

929352

DOHH
Deoxyhypusine hydroxylase

3

2

High-throughput

0.667

High

837919

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.633

High

929311

IF5AL
Eukaryotic translation initiation factor 5A-1-like

1

3

High-throughput

0.618

High

303134

HEXI1
Protein HEXIM1

2

2

High-throughput

0.611

High

132818

SDCB1
Syntenin-1

2

1

High-throughput

0.606

High

180977

GSC2
Homeobox protein goosecoid-2

2

2

High-throughput

0.606

High

858127

LBX1
Transcription factor LBX1

2

1

High-throughput

0.606

High

369361

ESR1
Estrogen receptor

2

1

Small-scale

0.595

High

929286

KPCZ
Protein kinase C zeta type

2

0

High-throughput

0.585

High

929371

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

929292

CUL3
Cullin-3

2

4

High-throughput

0.571

High

929351

SH3G3
Endophilin-A3

2

2

High-throughput

0.571

High

929379

GAB2
GRB2-associated-binding protein 2

2

2

High-throughput

0.571

High

503860

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

874805

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.559

High

916133

RL23A
Large ribosomal subunit protein uL23

2

0

Small-scale

0.559

High

929354

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

805949

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.549

High

197688

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.549

High

929377

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.536

High

547775

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

570519

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.536

High

617278

SP100
Nuclear autoantigen Sp-100

1

3

High-throughput

0.536

High

640231

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

1

High-throughput

0.536

High

647536

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

734908

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

851380

NEK3
Serine/threonine-protein kinase Nek3

1

3

High-throughput

0.536

High

929283

CDK6
Cyclin-dependent kinase 6

1

1

High-throughput

0.536

High

929291

CUL2
Cullin-2

1

4

High-throughput

0.536

High

929301

MYLK
Myosin light chain kinase, smooth muscle

1

2

High-throughput

0.536

High

929303

DUS7
Dual specificity protein phosphatase 7

1

4

High-throughput

0.536

High

929332

MK15
Mitogen-activated protein kinase 15

1

3

High-throughput

0.536

High

929334

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

929343

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

929369

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.536

High

929310

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

128529

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

154946

NDC80
Kinetochore protein NDC80 homolog

1

0

High-throughput

0.513

High

201294

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

236740

CCNT1
Cyclin-T1

1

0

High-throughput

0.513

High

336463

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

528946

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

725766

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

739064

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

929296

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

929298

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

929307

TENS2
Tensin-2

1

0

High-throughput

0.513

High

929316

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.513

High

929323

RBM45
RNA-binding protein 45

1

0

High-throughput

0.513

High

929328

RETR2
Reticulophagy regulator 2

1

0

High-throughput

0.513

High

929331

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

929355

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

929363

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.513

High

929380

TDRKH
Tudor and KH domain-containing protein

1

0

High-throughput

0.513

High

929360

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.508

High

902508

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

929279

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.501

High

929342

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.501

High

929358

XPO4
Exportin-4

1

1

Small-scale

0.501

High

157315

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

High-throughput

0.489

High

929321

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.489

High

162611

XPO1
Exportin-1

1

0

Small-scale

0.480

High

929372

SENP1
Sentrin-specific protease 1

1

0

Small-scale

0.480

High

244256

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

318602

EYA4
Eyes absent homolog 4

1

3

High-throughput

0.479

High

346471

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

445361

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

551496

TFE2
Transcription factor E2-alpha

1

1

High-throughput

0.479

High

569561

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

590820

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

613408

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

High-throughput

0.479

High

643317

HMGB2
High mobility group protein B2

1

3

High-throughput

0.479

High

742205

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

759609

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.479

High

771894

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

874071

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.479

High

896023

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

898259

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.479

High

908332

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

916493

RS6
Small ribosomal subunit protein eS6

1

1

Small-scale

0.479

High

922513

RL10A
Large ribosomal subunit protein uL1

1

1

Small-scale

0.479

High

929284

EWS
RNA-binding protein EWS

1

3

High-throughput

0.479

High

929287

DUS2
Dual specificity protein phosphatase 2

1

4

High-throughput

0.479

High

929290

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

1

High-throughput

0.479

High

929293

SRC8
Src substrate cortactin

1

2

High-throughput

0.479

High

929295

CUL7
Cullin-7

1

2

High-throughput

0.479

High

929297

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

929299

PDIA6
Protein disulfide-isomerase A6

1

2

High-throughput

0.479

High

929300

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.479

High

929302

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.479

High

929305

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

929308

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

929314

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

929318

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

929324

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

929326

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.479

High

929333

BICD2
Protein bicaudal D homolog 2

1

2

High-throughput

0.479

High

929336

DUS19
Dual specificity protein phosphatase 19

1

5

High-throughput

0.479

High

929337

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

1

High-throughput

0.479

High

929339

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.479

High

929341

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

929345

OPTN
Optineurin

1

2

High-throughput

0.479

High

929353

DUS26
Dual specificity protein phosphatase 26

1

4

High-throughput

0.479

High

929357

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

929365

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

929370

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

929375

DS13B
Dual specificity protein phosphatase 13B

1

4

High-throughput

0.479

High

929376

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

929378

DUS12
Dual specificity protein phosphatase 12

1

4

High-throughput

0.479

High

119323

LEG9
Galectin-9

1

0

High-throughput

0.458

High

199711

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

214903

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

263585

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.458

High

294679

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298402

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

315342

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.458

High

322458

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

335086

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

359839

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

381919

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

418152

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

455309

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

508442

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

521851

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

552466

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

632241

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

632684

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

641708

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

650920

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

673058

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

718735

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

724213

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

823854

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

828977

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

832344

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

833401

RBM25
RNA-binding protein 25

1

0

High-throughput

0.458

High

877684

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

903108

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

929280

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

929281

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.458

High

929282

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.458

High

929288

SRSF9
Serine/arginine-rich splicing factor 9

1

0

High-throughput

0.458

High

929289

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

929306

DDI2
Protein DDI1 homolog 2

1

0

High-throughput

0.458

High

929309

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

929312

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.458

High

929315

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

929317

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

929320

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

929322

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

929327

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

929329

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

929335

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

929338

ATX2L
Ataxin-2-like protein

1

0

High-throughput

0.458

High

929340

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

929344

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

929346

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

929348

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

929349

NECD
Necdin

1

0

High-throughput

0.458

High

929350

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

929361

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.458

High

929366

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

929368

ZN532
Zinc finger protein 532

1

0

High-throughput

0.458

High

929373

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

929374

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

929382

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

306094

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

401810

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

551111

ITF2
Transcription factor 4

1

1

High-throughput

0.445

High

883473

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

929362

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

929364

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

329624

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

929313

WDR82
WD repeat-containing protein 82

1

3

High-throughput

0.437

High

378023

PRIO
Major prion protein

1

0

High-throughput

0.426

High

496804

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

596533

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

717668

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

929325

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

929356

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

68351

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

929319

ST32C
Serine/threonine-protein kinase 32C

1

0

High-throughput

0.279

Low

929330

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

1010

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.253

Low

100666

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

225601

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

433138

LAMB1
Laminin subunit beta-1

1

0

High-throughput

0.249

Low

674647

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

720202

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

929294

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

929304

FA76B
Protein FAM76B

1

0

High-throughput

0.249

Low

929347

DYH8
Dynein axonemal heavy chain 8

1

0

High-throughput

0.249

Low

929367

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.249

Low

929381

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024