HitPredict

Interactor 1: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Interactor 2: MNT (Q99583)
Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)
Gene: MNT

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	9184233
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1273 Hs			1 582
+	Mm
		139906 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		MNT_MOUSE (1-582): 3.17e-74: 249: 92.56
+	Hs
		840222 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MXI1_HUMAN (180-363): 8.42e-39: 144: 24.87
+	Mm
		840195 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		MAD1_MOUSE (195-354): 2.84e-38: 142: 23.81
+	Mm
		840232 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		MXI1_MOUSE (180-363): 1.43e-37: 140: 24.35
+	Hs
		983439 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MAD1_HUMAN (195-341): 1.76e-33: 128: 23.68
+	Mm
		1141057 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		Q91VN7_MOUSE (195-357): 2.53e-31: 122: 23.81
+	Hs
		1302436 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MAD3_HUMAN (179-337): 2.45e-29: 117: 25.60
+	Hs
		898177 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MAX_HUMAN (206-336): 2.21e-29: 115: 28.03
+	Hs
		347665 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MYC_HUMAN (107-302): 9.58e-26: 112: 18.05
+	Hs
		1302487 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		CABIN_HUMAN (6-310): 1.07e-19: 95.8: 17.18
+	Hs
		738990 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		SRBP1_HUMAN (2-376): 3.27e-19: 94.2: 16.58
+	Mm
		1141064 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		SRBP1_MOUSE (49-376): 4.44e-17: 87.3: 17.21
+	Mm
		1141059 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		Q9JIZ5_MOUSE (209-501): 7.14e-16: 81.1: 15.41
+	Hs
		966281 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		TFAP4_HUMAN (209-461): 6.52e-14: 75.4: 15.79
+	Hs
		1056948 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MDC1_HUMAN (20-504): 7.87e-10: 64.2: 11.83
+	Mm
		139907 SIN3B_MOUSE (110-1273): 0: 1237: 51.12		MNT_MOUSE (1-582): 3.17e-74: 249: 92.56
+	Mm
		840196 SIN3B_MOUSE (110-1273): 0: 1237: 51.12		MAD1_MOUSE (195-354): 2.84e-38: 142: 23.81
+	Mm
		840233 SIN3B_MOUSE (110-1273): 0: 1237: 51.12		MXI1_MOUSE (180-363): 1.43e-37: 140: 24.35
+	Ce
		60879 SIN3_CAEEL (60-1079): 0: 716: 19.90		MXL3_CAEEL (220-318): 1.56e-21: 95.7: 30.30
+	Dm
		1137188 Q5U0Y0_DROME (35-539): 2.36e-50: 198: 21.88		X2JDM5_DROME (185-305): 1.59e-19: 94.7: 39.02