HitPredict

Interactor 1: EYA1 (Q99502)
Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)
Gene: EYA1

Interactor 2: SIX2 (Q9NPC8)
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Gene: SIX2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	27880917, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus GO:0007501 - mesodermal cell fate specification GO:0009653 - anatomical structure morphogenesis GO:0042474 - middle ear morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 592 Hs			1 291
+	Hs
		1074456 EYA1_HUMAN (1-592): 0: 571: 100.00		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		956886 EYA1_MOUSE (1-592): 0: 559: 96.12		SIX2_MOUSE (1-291): 2.19e-90: 272: 90.20
+	Mm
		956885 EYA1_MOUSE (1-592): 0: 559: 96.12		SIX1_MOUSE (1-291): 1.55e-86: 262: 71.53
+	Hs
		118611 EYA2_HUMAN (67-592): 0: 532: 64.83		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		1304297 EYA1_HUMAN (1-592): 0: 571: 100.00		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Hs
		118562 EYA2_HUMAN (67-592): 0: 532: 64.83		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		956884 EYA1_MOUSE (1-592): 0: 559: 96.12		SIX4_MOUSE (5-290): 1.25e-69: 231: 44.44
+	Hs
		318733 EYA4_HUMAN (1-592): 8.84e-173: 506: 68.49		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		92588 E9PLN6_HUMAN (1-592): 4.88e-172: 503: 69.28		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Mm
		956887 EYA1_MOUSE (1-592): 0: 559: 96.12		SIX3_MOUSE (1-245): 3.44e-71: 224: 57.43
+	Hs
		1230644 EYA1_HUMAN (1-592): 0: 571: 100.00		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		318622 EYA4_HUMAN (1-592): 8.84e-173: 506: 68.49		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Hs
		92587 E9PLN6_HUMAN (1-592): 4.88e-172: 503: 69.28		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		936193 EYA1_MOUSE (1-592): 0: 559: 96.12		SIX5_MOUSE (1-263): 1.16e-60: 206: 45.87
+	Hs
		118619 EYA2_HUMAN (67-592): 0: 532: 64.83		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Mm
		1143690 EYA4_MOUSE (1-592): 6.53e-168: 493: 69.62		SIX1_MOUSE (1-291): 1.55e-86: 262: 71.53
+	Mm
		139225 EYA2_MOUSE (48-592): 2.01e-177: 514: 62.75		SIX4_MOUSE (5-290): 1.25e-69: 231: 44.44
+	Hs
		318748 EYA4_HUMAN (1-592): 8.84e-173: 506: 68.49		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Hs
		318670 EYA4_HUMAN (1-592): 8.84e-173: 506: 68.49		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		1230645 EYA3_HUMAN (41-592): 1.55e-159: 470: 50.99		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66