HitPredict

Interactor 1: DNJC7 (Q99615)
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)
Gene: DNAJC7

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	26496610, 33957083, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC3~TPR_11, ANAPC3~TPR_8
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031072 - heat shock protein binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 303
+	Hs
		1234369 DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00		WDTC1_HUMAN (21-272): 3.45e-30: 122: 18.82
+	Hs
		279360 DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		1245931 DNJB8_HUMAN (381-482): 1.21e-15: 78.2: 44.35		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		174501 OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59		TOM70_HUMAN (4-212): 8.69e-40: 148: 22.47
+	Hs
		174743 OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		685025 STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49		UN45A_HUMAN (15-161): 8.39e-42: 155: 29.30
+	Hs
		297080 TTC28_HUMAN (1-320): 1.04e-19: 95.1: 15.27		TOM70_HUMAN (4-212): 8.69e-40: 148: 22.47
+	Hs
		684549 STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		213490 STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49		SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71
+	Dm
		1366835 Q9VPN5_DROME (7-171): 3.79e-22: 101: 29.09		Q9VH81_DROME (4-246): 6.54e-32: 125: 16.87
+	Mm
		1141207 PPP5_MOUSE (139-260): 3.58e-16: 82.8: 13.93		PPP5_MOUSE (1-259): 7.23e-36: 136: 20.91
+	Hs
		672793 CDC27_HUMAN (4-128): 1.63e-15: 81.6: 20.80		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Mm
		1194908 DNJB4_MOUSE (380-479): 3.28e-18: 87.8: 44.35		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22
+	Hs
		858598 PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		174456 OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59		KDM6A_HUMAN (25-206): 2.59e-10: 63.1: 13.02
+	Hs
		858652 PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79		WDTC1_HUMAN (21-272): 3.45e-30: 122: 18.82