Protein: UBP8
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)

Gene: UBP8, USP8
Organism: Homo sapiens
Interactions: 140
UniProt ID: P40818

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0002080 - acrosomal membrane
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507635

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

10

20

Small-scale

0.973

High

828253

RNF41
E3 ubiquitin-protein ligase NRDP1

5

20

Small-scale

0.930

High

828200

CD83
CD83 antigen

2

1

High-throughput

0.811

High

828257

PD1L1
Programmed cell death 1 ligand 1

2

5

Small-scale

0.806

High

729655

1433B
14-3-3 protein beta/alpha

9

20

Small-scale

0.754

High

828197

1433Z
14-3-3 protein zeta/delta

8

20

Small-scale

0.750

High

690802

1433T
14-3-3 protein theta

8

20

Small-scale

0.749

High

828195

1433E
14-3-3 protein epsilon

7

3

Small-scale

0.748

High

362903

EGFR
Epidermal growth factor receptor

6

14

Small-scale

0.729

High

828193

1433G
14-3-3 protein gamma

5

20

High-throughput

0.716

High

292814

GRAP2
GRB2-related adapter protein 2

5

17

Small-scale

0.716

High

828190

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

13

High-throughput

0.698

High

828235

STAM1
Signal transducing adapter molecule 1

4

9

Small-scale

0.694

High

828261

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

13

High-throughput

0.691

High

828203

1433F
14-3-3 protein eta

4

20

High-throughput

0.690

High

296452

STAM2
Signal transducing adapter molecule 2

4

10

Small-scale

0.689

High

828222

CHM1B
Charged multivesicular body protein 1b

3

10

Small-scale

0.687

High

730427

1433S
14-3-3 protein sigma

3

20

Small-scale

0.657

High

828243

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

16

High-throughput

0.647

High

828259

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

High-throughput

0.647

High

828266

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

16

High-throughput

0.647

High

828256

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

3

12

Small-scale

0.640

High

192991

CFLAR
CASP8 and FADD-like apoptosis regulator

2

4

Small-scale

0.634

High

791146

SYUA
Alpha-synuclein

2

3

Small-scale

0.633

High

828255

CHM1A
Charged multivesicular body protein 1a

2

9

Small-scale

0.629

High

213846

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

9

Small-scale

0.624

High

240965

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.618

High

728078

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.618

High

828209

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.618

High

828237

CHM4C
Charged multivesicular body protein 4c

2

8

Small-scale

0.613

High

828268

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

1

High-throughput

0.601

High

411505

NTRK1
High affinity nerve growth factor receptor

2

12

High-throughput

0.584

High

603867

CXA1
Gap junction alpha-1 protein

2

2

Small-scale

0.584

High

828184

NOTC1
Neurogenic locus notch homolog protein 1

2

16

Small-scale

0.584

High

788858

TGFR2
TGF-beta receptor type-2

1

12

Small-scale

0.578

High

828206

SQSTM
Sequestosome-1

1

5

Small-scale

0.578

High

828216

NTRK2
BDNF/NT-3 growth factors receptor

1

15

Small-scale

0.578

High

828180

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

14

Small-scale

0.575

High

484071

PGFRB
Platelet-derived growth factor receptor beta

2

4

High-throughput

0.571

High

828183

EPS15
Epidermal growth factor receptor substrate 15

1

2

Small-scale

0.561

High

828215

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.561

High

828217

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.561

High

828244

EPAS1
Endothelial PAS domain-containing protein 1

1

8

Small-scale

0.561

High

828204

TADBP
TAR DNA-binding protein 43

1

10

Small-scale

0.552

High

300554

KRT36
Keratin, type I cuticular Ha6

1

19

High-throughput

0.536

High

828198

KRT85
Keratin, type II cuticular Hb5

1

7

High-throughput

0.536

High

828213

K1H1
Keratin, type I cuticular Ha1

1

18

High-throughput

0.536

High

828225

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.536

High

828229

TPC2
Two pore channel protein 2

1

1

High-throughput

0.536

High

828231

ACTT1
Actin-related protein T1

1

3

High-throughput

0.536

High

828208

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.529

High

828207

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

828230

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

0

High-throughput

0.513

High

221838

CHM2A
Charged multivesicular body protein 2a

1

6

Small-scale

0.501

High

323845

SC31A
Protein transport protein Sec31A

1

7

Small-scale

0.501

High

557148

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

Small-scale

0.501

High

572742

PA2GA
Phospholipase A2, membrane associated

1

4

Small-scale

0.501

High

828189

BACE1
Beta-secretase 1

1

1

Small-scale

0.501

High

828196

GRB2
Growth factor receptor-bound protein 2

1

9

Small-scale

0.501

High

828218

H2A2C
Histone H2A type 2-C

1

15

Small-scale

0.501

High

828219

H2B2E
Histone H2B type 2-E

1

15

Small-scale

0.501

High

828227

PJA1
E3 ubiquitin-protein ligase Praja-1

1

4

High-throughput

0.501

High

828234

CHMP7
Charged multivesicular body protein 7

1

11

Small-scale

0.501

High

828236

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

828239

CHMP6
Charged multivesicular body protein 6

1

9

Small-scale

0.501

High

828247

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

Small-scale

0.501

High

828248

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

828249

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.501

High

828252

CHM4B
Charged multivesicular body protein 4b

1

8

Small-scale

0.501

High

828258

CHMP5
Charged multivesicular body protein 5

1

12

Small-scale

0.501

High

828262

CHM2B
Charged multivesicular body protein 2b

1

11

Small-scale

0.501

High

828263

CHMP3
Charged multivesicular body protein 3

1

11

Small-scale

0.501

High

828267

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

8

Small-scale

0.501

High

828188

IST1
IST1 homolog

1

0

High-throughput

0.493

High

194809

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

2

Small-scale

0.479

High

217917

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

225946

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

395629

ESR1
Estrogen receptor

1

14

Small-scale

0.479

High

403889

GCR
Glucocorticoid receptor

1

12

High-throughput

0.479

High

468142

HS90B
Heat shock protein HSP 90-beta

1

12

High-throughput

0.479

High

488425

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

11

Small-scale

0.479

High

541380

FGFR1
Fibroblast growth factor receptor 1

1

14

High-throughput

0.479

High

555927

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

560318

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

572420

DRD2
D(2) dopamine receptor

1

1

Small-scale

0.479

High

587581

DESP
Desmoplakin

1

9

High-throughput

0.479

High

588093

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

593299

PGFRA
Platelet-derived growth factor receptor alpha

1

4

High-throughput

0.479

High

641134

FGFR2
Fibroblast growth factor receptor 2

1

11

High-throughput

0.479

High

641505

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

11

Small-scale

0.479

High

648445

FGFR4
Fibroblast growth factor receptor 4

1

14

High-throughput

0.479

High

675393

TYY1
Transcriptional repressor protein YY1

1

3

Small-scale

0.479

High

694808

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

710103

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

761185

RYK
Tyrosine-protein kinase RYK

1

16

High-throughput

0.479

High

764505

CTNB1
Catenin beta-1

1

10

Small-scale

0.479

High

788517

SCNNA
Epithelial sodium channel subunit alpha

1

6

Small-scale

0.479

High

828181

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

828182

ID1
DNA-binding protein inhibitor ID-1

1

2

Small-scale

0.479

High

828186

SCNNB
Epithelial sodium channel subunit beta

1

6

Small-scale

0.479

High

828187

SCNNG
Epithelial sodium channel subunit gamma

1

6

Small-scale

0.479

High

828192

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.479

High

828194

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.479

High

828201

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

828202

KIF23
Kinesin-like protein KIF23

1

5

Small-scale

0.479

High

828205

FZD5
Frizzled-5

1

2

Small-scale

0.479

High

828210

EEA1
Early endosome antigen 1

1

11

High-throughput

0.479

High

828211

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.479

High

828212

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

13

Small-scale

0.479

High

828214

SIX1
Homeobox protein SIX1

1

1

Small-scale

0.479

High

828220

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

828223

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

828224

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

828232

RN128
E3 ubiquitin-protein ligase RNF128

1

6

Small-scale

0.479

High

828238

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.479

High

828240

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

2

Small-scale

0.479

High

828242

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

828246

VAMP8
Vesicle-associated membrane protein 8

1

3

Small-scale

0.479

High

828250

P63
Tumor protein 63

1

6

Small-scale

0.479

High

828251

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

4

Small-scale

0.479

High

828260

MUC12
Mucin-12

1

5

Small-scale

0.479

High

828264

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

828265

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

828185

LEPR
Leptin receptor

1

2

Small-scale

0.470

High

828226

MCPH1
Microcephalin

1

0

Small-scale

0.458

High

828254

EPG5
Ectopic P granules protein 5 homolog

1

0

Small-scale

0.458

High

828199

DLK1
Protein delta homolog 1

1

11

High-throughput

0.445

High

828221

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.445

High

828241

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

179830

BET1
BET1 homolog

1

1

High-throughput

0.437

High

767585

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

828228

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.426

High

70949

IQCF5
IQ domain-containing protein F5

1

0

High-throughput

0.269

Low

522247

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

571388

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

828245

TMM79
Transmembrane protein 79

1

0

Small-scale

0.249

Low

828191

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

231793

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.232

Low

828233

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025