HitPredict

Interactor 1: CCL19 (Q99731)
C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19)
Gene: CCL19

Interactor 2: ACKR4 (Q9NPB9)
Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
Gene: ACKR4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	10706668
Identification Methods	pull down, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006955 - immune response GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 98 Hs			1 350
+	Hs
		1305163 CCL13_HUMAN (2-94): 4.26e-29: 102: 26.32		ACKR4_HUMAN (1-350): 4.66e-89: 272: 100.00
+	Hs
		561732 CL3L1_HUMAN (1-90): 3.74e-30: 104: 30.00		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		849619 CCL13_HUMAN (2-94): 4.26e-29: 102: 26.32		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		486237 CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		849616 CCL14_HUMAN (4-89): 9.46e-29: 100: 24.42		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		134400 CCL13_HUMAN (2-94): 4.26e-29: 102: 26.32		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134354 CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134380 CCL14_HUMAN (4-89): 9.46e-29: 100: 24.42		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Mm
		291526 CCL11_MOUSE (2-95): 1.24e-28: 100: 27.66		CXCR3_MOUSE (3-349): 2.46e-79: 248: 28.29
+	Hs
		783833 CCL13_HUMAN (2-94): 4.26e-29: 102: 26.32		CCR2_HUMAN (1-327): 1.37e-72: 231: 29.39
+	Hs
		561733 CL3L1_HUMAN (1-90): 3.74e-30: 104: 30.00		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		561728 CL3L1_HUMAN (1-90): 3.74e-30: 104: 30.00		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		830629 CCL13_HUMAN (2-94): 4.26e-29: 102: 26.32		CXCR3_HUMAN (2-349): 7.54e-71: 227: 29.63
+	Hs
		849654 CCL13_HUMAN (2-94): 4.26e-29: 102: 26.32		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		486239 CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		486230 CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		686667 CCL14_HUMAN (4-89): 9.46e-29: 100: 24.42		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		486238 CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78		CCR4_HUMAN (3-322): 9.71e-69: 221: 34.26
+	Mm
		849656 CCL8_MOUSE (2-95): 1.52e-28: 100: 28.72		CCR5_MOUSE (27-348): 2.3e-67: 217: 30.06
+	Hs
		486231 CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78		CXCR5_HUMAN (1-350): 1.49e-64: 210: 26.45