Protein: ERG
Transcriptional regulator ERG (Transforming protein ERG)

Gene: ERG
Organism: Homo sapiens
Interactions: 227
UniProt ID: P11308

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507357

ETS2
Protein C-ets-2

2

18

Small-scale

0.783

High

507401

FLI1
Friend leukemia integration 1 transcription factor

2

18

Small-scale

0.754

High

487080

ANDR
Androgen receptor

4

12

Small-scale

0.694

High

455029

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.664

High

507398

PRKDC
DNA-dependent protein kinase catalytic subunit

2

8

Small-scale

0.664

High

214057

SPOP
Speckle-type POZ protein

2

4

Small-scale

0.657

High

507483

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

Small-scale

0.639

High

161946

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

2

7

Small-scale

0.624

High

400727

RLA0
Large ribosomal subunit protein uL10

2

1

Small-scale

0.624

High

507367

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

6

Small-scale

0.624

High

507394

ACTB
Actin, cytoplasmic 1

2

3

Small-scale

0.624

High

507400

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

13

Small-scale

0.624

High

507431

PCBP1
Poly(rC)-binding protein 1

2

1

Small-scale

0.624

High

507450

PRP8
Pre-mRNA-processing-splicing factor 8

2

1

Small-scale

0.624

High

507352

ERG
Transcriptional regulator ERG

1

17

Small-scale

0.618

High

507362

SPI1
Transcription factor PU.1

1

17

Small-scale

0.618

High

507384

ETV1
ETS translocation variant 1

1

18

Small-scale

0.618

High

507454

BCOR
BCL-6 corepressor

1

10

High-throughput

0.618

High

277904

PIAS1
E3 SUMO-protein ligase PIAS1

2

14

High-throughput

0.614

High

507484

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

12

High-throughput

0.614

High

507407

RING1
E3 ubiquitin-protein ligase RING1

2

20

Small-scale

0.595

High

507528

TRI33
E3 ubiquitin-protein ligase TRIM33

2

20

Small-scale

0.595

High

503323

HSP7C
Heat shock cognate 71 kDa protein

2

5

Small-scale

0.584

High

507409

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

135069

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.578

High

507411

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.578

High

507421

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

Small-scale

0.578

High

243276

DNJA2
DnaJ homolog subfamily A member 2

1

4

Small-scale

0.561

High

256938

KDM4A
Lysine-specific demethylase 4A

1

4

Small-scale

0.561

High

263494

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

Small-scale

0.561

High

272021

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

3

Small-scale

0.561

High

417885

NPM
Nucleophosmin

1

1

Small-scale

0.561

High

432524

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

Small-scale

0.561

High

443120

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

453105

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

Small-scale

0.561

High

507354

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.561

High

507363

NUCL
Nucleolin

1

2

Small-scale

0.561

High

507368

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

Small-scale

0.561

High

507376

DNJA1
DnaJ homolog subfamily A member 1

1

4

Small-scale

0.561

High

507377

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

5

Small-scale

0.561

High

507378

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

Small-scale

0.561

High

507389

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

5

Small-scale

0.561

High

507392

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

Small-scale

0.561

High

507402

TOP2B
DNA topoisomerase 2-beta

1

1

Small-scale

0.561

High

507412

ILF2
Interleukin enhancer-binding factor 2

1

2

Small-scale

0.561

High

507413

ILF3
Interleukin enhancer-binding factor 3

1

3

Small-scale

0.561

High

507420

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

7

Small-scale

0.561

High

507426

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.561

High

507427

NUMA1
Nuclear mitotic apparatus protein 1

1

1

Small-scale

0.561

High

507430

NONO
Non-POU domain-containing octamer-binding protein

1

3

Small-scale

0.561

High

507432

SF3B3
Splicing factor 3B subunit 3

1

4

Small-scale

0.561

High

507435

ELAV1
ELAV-like protein 1

1

1

Small-scale

0.561

High

507439

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

13

Small-scale

0.561

High

507492

CDC5L
Cell division cycle 5-like protein

1

6

Small-scale

0.561

High

507494

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

7

Small-scale

0.561

High

507500

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

13

Small-scale

0.561

High

507501

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

Small-scale

0.561

High

507515

DDX21
Nucleolar RNA helicase 2

1

5

Small-scale

0.561

High

507517

RCC2
Protein RCC2

1

2

Small-scale

0.561

High

507524

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

Small-scale

0.561

High

71381

B2Y833
TMPRSS2-ERG prostate cancer specific isoform 1

1

15

Small-scale

0.559

High

507355

XRCC6
X-ray repair cross-complementing protein 6

1

12

Small-scale

0.554

High

507356

XRCC5
X-ray repair cross-complementing protein 5

1

12

Small-scale

0.554

High

507380

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.541

High

507393

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.541

High

507436

NDF2
Neurogenic differentiation factor 2

1

12

High-throughput

0.541

High

507455

RN111
E3 ubiquitin-protein ligase Arkadia

1

8

High-throughput

0.541

High

507463

HIPK1
Homeodomain-interacting protein kinase 1

1

6

High-throughput

0.541

High

507465

SLX4
Structure-specific endonuclease subunit SLX4

1

20

High-throughput

0.541

High

507467

ZBT44
Zinc finger and BTB domain-containing protein 44

1

5

High-throughput

0.541

High

507505

WDR13
WD repeat-containing protein 13

1

9

High-throughput

0.541

High

507519

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.541

High

507521

ZMYM2
Zinc finger MYM-type protein 2

1

5

High-throughput

0.541

High

507536

PIAS3
E3 SUMO-protein ligase PIAS3

1

14

High-throughput

0.541

High

242342

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

Small-scale

0.537

High

268589

SF3B1
Splicing factor 3B subunit 1

1

0

Small-scale

0.537

High

499489

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.537

High

507366

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.537

High

507370

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.537

High

507381

MATR3
Matrin-3

1

0

Small-scale

0.537

High

507399

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.537

High

507416

SF3B2
Splicing factor 3B subunit 2

1

0

Small-scale

0.537

High

507503

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.537

High

507471

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

High-throughput

0.536

High

507365

MSH3
DNA mismatch repair protein Msh3

1

0

High-throughput

0.518

High

507387

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.518

High

507406

EXOS9
Exosome complex component RRP45

1

0

High-throughput

0.518

High

507414

TARB1
Probable methyltransferase TARBP1

1

0

High-throughput

0.518

High

507441

ZBED5
Zinc finger BED domain-containing protein 5

1

0

High-throughput

0.518

High

507486

ARK2N
Protein ARK2N

1

0

High-throughput

0.518

High

507533

MYO5A
Unconventional myosin-Va

1

0

High-throughput

0.518

High

507360

SYN1
Synapsin-1

1

20

Small-scale

0.512

High

507405

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.512

High

304005

UBR5
E3 ubiquitin-protein ligase UBR5

1

5

Small-scale

0.501

High

319699

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

Small-scale

0.501

High

394010

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

401313

JUN
Transcription factor Jun

1

17

Small-scale

0.501

High

507422

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

5

Small-scale

0.501

High

507445

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.501

High

507446

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.501

High

507460

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

Small-scale

0.501

High

507474

DNJA4
DnaJ homolog subfamily A member 4

1

4

Small-scale

0.501

High

507491

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

20

Small-scale

0.501

High

507493

RING2
E3 ubiquitin-protein ligase RING2

1

20

Small-scale

0.501

High

507527

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

Small-scale

0.501

High

507375

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.500

High

131687

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

133857

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

Small-scale

0.479

High

146146

ARI1A
AT-rich interactive domain-containing protein 1A

1

19

High-throughput

0.479

High

152581

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

164179

ZN609
Zinc finger protein 609

1

13

High-throughput

0.479

High

170228

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

183057

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

243846

BRD4
Bromodomain-containing protein 4

1

20

Small-scale

0.479

High

252899

MITF
Microphthalmia-associated transcription factor

1

2

High-throughput

0.479

High

257445

CREST
Calcium-responsive transactivator

1

20

High-throughput

0.479

High

261385

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.479

High

398626

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

1

Small-scale

0.479

High

427986

TBB5
Tubulin beta chain

1

8

Small-scale

0.479

High

435513

IGF1R
Insulin-like growth factor 1 receptor

1

4

Small-scale

0.479

High

451182

TPM1
Tropomyosin alpha-1 chain

1

3

Small-scale

0.479

High

473465

ATX1L
Ataxin-1-like

1

10

High-throughput

0.479

High

507353

PIM1
Serine/threonine-protein kinase pim-1

1

2

Small-scale

0.479

High

507359

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.479

High

507361

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

Small-scale

0.479

High

507364

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.479

High

507371

BRD2
Bromodomain-containing protein 2

1

20

Small-scale

0.479

High

507373

RBTN2
Rhombotin-2

1

10

Small-scale

0.479

High

507374

PYR1
Multifunctional protein CAD

1

2

Small-scale

0.479

High

507379

HSP74
Heat shock 70 kDa protein 4

1

6

Small-scale

0.479

High

507382

GATA4
Transcription factor GATA-4

1

9

High-throughput

0.479

High

507383

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.479

High

507385

SMCA2
Probable global transcription activator SNF2L2

1

17

High-throughput

0.479

High

507386

SMCA4
Transcription activator BRG1

1

18

High-throughput

0.479

High

507388

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

Small-scale

0.479

High

507390

ATX1
Ataxin-1

1

10

High-throughput

0.479

High

507391

AF10
Protein AF-10

1

5

High-throughput

0.479

High

507395

LMO4
LIM domain transcription factor LMO4

1

10

High-throughput

0.479

High

507396

RS18
Small ribosomal subunit protein uS13

1

1

Small-scale

0.479

High

507397

RL7A
Large ribosomal subunit protein eL8

1

1

Small-scale

0.479

High

507403

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

507404

TLE3
Transducin-like enhancer protein 3

1

17

High-throughput

0.479

High

507408

TLE5
TLE family member 5

1

14

High-throughput

0.479

High

507410

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.479

High

507417

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

507418

CUL3
Cullin-3

1

1

Small-scale

0.479

High

507419

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

3

Small-scale

0.479

High

507423

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.479

High

507425

MEF2D
Myocyte-specific enhancer factor 2D

1

1

High-throughput

0.479

High

507428

SETB1
Histone-lysine N-methyltransferase SETDB1

1

15

Small-scale

0.479

High

507429

BRD3
Bromodomain-containing protein 3

1

20

Small-scale

0.479

High

507433

SSXT
Protein SSXT

1

20

High-throughput

0.479

High

507434

NCOA2
Nuclear receptor coactivator 2

1

19

High-throughput

0.479

High

507437

EZH2
Histone-lysine N-methyltransferase EZH2

1

19

Small-scale

0.479

High

507442

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

507443

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

7

High-throughput

0.479

High

507444

PRC2B
Protein PRRC2B

1

14

High-throughput

0.479

High

507447

NIPBL
Nipped-B-like protein

1

11

High-throughput

0.479

High

507449

ZN746
Zinc finger protein 746

1

3

High-throughput

0.479

High

507451

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

3

High-throughput

0.479

High

507452

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

12

High-throughput

0.479

High

507453

MCAF1
Activating transcription factor 7-interacting protein 1

1

19

High-throughput

0.479

High

507456

CO039
Uncharacterized protein C15orf39

1

9

High-throughput

0.479

High

507457

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

507458

ASXL2
Putative Polycomb group protein ASXL2

1

19

High-throughput

0.479

High

507459

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

High-throughput

0.479

High

507461

LDB1
LIM domain-binding protein 1

1

1

High-throughput

0.479

High

507462

ZFHX4
Zinc finger homeobox protein 4

1

4

High-throughput

0.479

High

507464

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

507466

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.479

High

507468

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

507469

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

507470

KDM2B
Lysine-specific demethylase 2B

1

15

High-throughput

0.479

High

507472

MORC4
MORC family CW-type zinc finger protein 4

1

3

High-throughput

0.479

High

507473

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

7

High-throughput

0.479

High

507475

MAML1
Mastermind-like protein 1

1

20

High-throughput

0.479

High

507476

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.479

High

507477

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

507478

DPF3
Zinc finger protein DPF3

1

20

High-throughput

0.479

High

507479

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

507480

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

507481

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

507482

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

507485

ISL2
Insulin gene enhancer protein ISL-2

1

6

High-throughput

0.479

High

507487

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

507488

ZN521
Zinc finger protein 521

1

1

High-throughput

0.479

High

507490

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

507495

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

507496

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

7

High-throughput

0.479

High

507497

PYGO2
Pygopus homolog 2

1

1

High-throughput

0.479

High

507498

PCGF1
Polycomb group RING finger protein 1

1

14

High-throughput

0.479

High

507502

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

12

Small-scale

0.479

High

507504

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

1

High-throughput

0.479

High

507506

HIPK2
Homeodomain-interacting protein kinase 2

1

2

High-throughput

0.479

High

507507

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

507509

ZN703
Zinc finger protein 703

1

9

High-throughput

0.479

High

507513

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

507514

TF7L2
Transcription factor 7-like 2

1

19

High-throughput

0.479

High

507516

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

19

High-throughput

0.479

High

507518

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

12

High-throughput

0.479

High

507520

RERE
Arginine-glutamic acid dipeptide repeats protein

1

9

High-throughput

0.479

High

507522

TCF20
Transcription factor 20

1

17

High-throughput

0.479

High

507523

TRPS1
Zinc finger transcription factor Trps1

1

10

High-throughput

0.479

High

507525

ZN608
Zinc finger protein 608

1

5

High-throughput

0.479

High

507526

PRR12
Proline-rich protein 12

1

14

High-throughput

0.479

High

507529

SATB2
DNA-binding protein SATB2

1

5

High-throughput

0.479

High

507530

ZN148
Zinc finger protein 148

1

10

High-throughput

0.479

High

507531

ZN281
Zinc finger protein 281

1

10

High-throughput

0.479

High

507532

ARIP4
Helicase ARIP4

1

20

High-throughput

0.479

High

507534

NCOR2
Nuclear receptor corepressor 2

1

15

High-throughput

0.479

High

507535

NCOA3
Nuclear receptor coactivator 3

1

19

High-throughput

0.479

High

507358

NDKA
Nucleoside diphosphate kinase A

1

0

Small-scale

0.458

High

507415

XRCC4
DNA repair protein XRCC4

1

0

Small-scale

0.458

High

507448

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

507499

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.458

High

507511

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

507438

DREB
Drebrin

1

2

High-throughput

0.457

High

507372

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

507424

GSE1
Genetic suppressor element 1

1

1

High-throughput

0.437

High

507440

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

507508

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

507510

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

507512

FBSL
Fibrosin-1-like protein

1

3

High-throughput

0.437

High

215098

LANC1
Glutathione S-transferase LANCL1

1

0

Small-scale

0.292

High

507369

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

0

High-throughput

0.282

High

507489

F218A
Protein FAM218A

1

0

High-throughput

0.282

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024