HitPredict

Interactor 1: NPAS2 (Q99743)
Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)
Gene: NPAS2

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	14645221
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0046983 - protein dimerization activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 824 Hs			1 1424
+	Hs
		1264406 NPAS2_HUMAN (1-824): 3.41e-135: 423: 100.00		BMAL2_HUMAN (10-541): 1.06e-108: 360: 16.06
+	Hs
		1085577 HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		126165 NPAS2_HUMAN (1-824): 3.41e-135: 423: 100.00		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Mm
		139879 CLOCK_MOUSE (1-824): 6.7e-129: 408: 47.85		BMAL1_MOUSE (6-541): 2.82e-108: 359: 18.94
+	Mm
		1142409 HIF1A_MOUSE (2-798): 4.47e-128: 405: 15.14		BMAL1_MOUSE (6-541): 2.82e-108: 359: 18.94
+	Hs
		181548 CLOCK_HUMAN (1-782): 2.98e-127: 403: 48.81		BMAL2_HUMAN (10-541): 1.06e-108: 360: 16.06
+	Hs
		126089 CLOCK_HUMAN (1-782): 2.98e-127: 403: 48.81		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		126132 HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		87730 D0VY79_HUMAN (2-798): 6.81e-126: 399: 16.22		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Mm
		139865 CLOCK_MOUSE (1-824): 6.7e-129: 408: 47.85		BMAL2_MOUSE (27-541): 1.22e-90: 307: 16.58
+	Hs
		181557 NPAS2_HUMAN (1-824): 3.41e-135: 423: 100.00		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		649149 NPAS2_HUMAN (1-824): 3.41e-135: 423: 100.00		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Mm
		1012216 HIF1A_MOUSE (2-798): 4.47e-128: 405: 15.14		HIF3A_MOUSE (20-674): 3.24e-79: 277: 15.16
+	Hs
		181489 CLOCK_HUMAN (1-782): 2.98e-127: 403: 48.81		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		1306192 NPAS2_HUMAN (1-824): 3.41e-135: 423: 100.00		ARNT2_HUMAN (1-620): 6.44e-72: 257: 16.69
+	Hs
		1078515 HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		181499 CLOCK_HUMAN (1-782): 2.98e-127: 403: 48.81		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		649123 HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Mm
		864794 HIF1A_MOUSE (2-798): 4.47e-128: 405: 15.14		ARNT_MOUSE (6-673): 3.97e-70: 254: 16.23