Protein: CATD
Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]

Gene: CATD, CTSD
Organism: Homo sapiens
Interactions: 137
UniProt ID: P07339

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0004190 - aspartic-type endopeptidase activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

330756

NAPSA
Napsin-A

3

1

High-throughput

0.861

High

427122

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

0

High-throughput

0.630

High

427049

SPB3
Serpin B3

1

1

High-throughput

0.618

High

427053

SPB5
Serpin B5

1

1

High-throughput

0.618

High

427033

TAU
Microtubule-associated protein tau

2

2

Small-scale

0.585

High

427126

FBX6
F-box only protein 6

2

2

High-throughput

0.584

High

427061

PPT1
Palmitoyl-protein thioesterase 1

2

0

Small-scale

0.559

High

427100

TM192
Transmembrane protein 192

2

0

High-throughput

0.559

High

427070

CCL20
C-C motif chemokine 20

1

3

Small-scale

0.536

High

277398

RASF9
Ras association domain-containing protein 9

1

2

High-throughput

0.536

High

421946

LDHB
L-lactate dehydrogenase B chain

1

1

High-throughput

0.536

High

427045

CALX
Calnexin

1

3

High-throughput

0.536

High

427060

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.536

High

177790

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.515

High

125092

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.515

High

427036

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

427040

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

427110

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

427142

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.512

High

134286

CCL21
C-C motif chemokine 21

1

3

Small-scale

0.501

High

393936

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.501

High

427032

CCL3
C-C motif chemokine 3

1

3

Small-scale

0.501

High

427035

CCL4
C-C motif chemokine 4

1

3

Small-scale

0.501

High

427069

HBA
Hemoglobin subunit alpha

1

1

Small-scale

0.501

High

168594

NPFF
Pro-FMRFamide-related neuropeptide FF

1

0

High-throughput

0.493

High

427056

VDAC2
Voltage-dependent anion-selective channel protein 2

1

0

High-throughput

0.493

High

427068

H31
Histone H3.1

1

0

High-throughput

0.493

High

427111

PGRP3
Peptidoglycan recognition protein 3

1

0

High-throughput

0.493

High

63630

RASFA
Ras association domain-containing protein 10

1

1

High-throughput

0.489

High

427071

RASF7
Ras association domain-containing protein 7

1

2

High-throughput

0.489

High

427078

CUL2
Cullin-2

1

3

High-throughput

0.489

High

427108

CUL5
Cullin-5

1

3

High-throughput

0.489

High

427114

SH23A
SH2 domain-containing protein 3A

1

1

High-throughput

0.489

High

427047

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.486

High

427054

SYUA
Alpha-synuclein

1

0

Small-scale

0.480

High

133845

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

329248

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

427027

INVO
Involucrin

1

1

High-throughput

0.479

High

427028

SAP
Prosaposin

1

3

Small-scale

0.479

High

427037

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.479

High

427038

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.479

High

427042

EFNA1
Ephrin-A1

1

1

High-throughput

0.479

High

427048

GRN
Progranulin

1

1

Small-scale

0.479

High

427050

CASPE
Caspase-14

1

1

High-throughput

0.479

High

427051

1433S
14-3-3 protein sigma

1

2

High-throughput

0.479

High

427057

LEG7
Galectin-7

1

1

High-throughput

0.479

High

427062

EFNA4
Ephrin-A4

1

1

High-throughput

0.479

High

427067

1433Z
14-3-3 protein zeta/delta

1

2

Small-scale

0.479

High

427097

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

427106

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

427128

T106B
Transmembrane protein 106B

1

2

Small-scale

0.479

High

427136

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

427138

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

Small-scale

0.479

High

427090

ZDH20
Palmitoyltransferase ZDHHC20

1

1

High-throughput

0.470

High

427095

GP141
Probable G-protein coupled receptor 141

1

1

High-throughput

0.470

High

427118

SPY4
Protein sprouty homolog 4

1

2

High-throughput

0.470

High

380927

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

337780

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

345708

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

427031

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

427034

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

427043

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

427063

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

427066

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.458

High

427082

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

427101

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

427112

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

427132

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.458

High

427133

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.458

High

427140

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

174554

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.457

High

427096

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

3

Small-scale

0.457

High

427029

ELNE
Neutrophil elastase

1

2

Small-scale

0.457

High

427041

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.445

High

427055

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.445

High

204937

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

282483

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.437

High

427065

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

427076

IKZF1
DNA-binding protein Ikaros

1

1

High-throughput

0.437

High

427077

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

427079

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

427080

PKP1
Plakophilin-1

1

1

High-throughput

0.437

High

427081

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.437

High

427107

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

427109

KISSR
KiSS-1 receptor

1

1

Small-scale

0.437

High

427116

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.437

High

427119

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

427120

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.437

High

427137

IKZF3
Zinc finger protein Aiolos

1

1

High-throughput

0.437

High

427121

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.426

High

427074

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

427058

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.279

Low

427073

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.279

Low

427075

ILK
Integrin-linked protein kinase

1

0

High-throughput

0.279

Low

427087

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.279

Low

427091

JADE1
Protein Jade-1

1

0

High-throughput

0.279

Low

427115

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.279

Low

427124

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.279

Low

427127

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

427093

ZN497
Zinc finger protein 497

1

0

High-throughput

0.278

Low

111208

I6L9I8
EPN3 protein

1

0

High-throughput

0.268

Low

427030

IG2R
Putative insulin-like growth factor 2-associated protein

1

0

High-throughput

0.268

Low

427046

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.268

Low

427072

KIF1A
Kinesin-like protein KIF1A

1

0

High-throughput

0.268

Low

427083

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.268

Low

427089

LCE2A
Late cornified envelope protein 2A

1

0

High-throughput

0.268

Low

427098

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.268

Low

427102

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

0

High-throughput

0.268

Low

427113

SYT3
Synaptotagmin-3

1

0

High-throughput

0.268

Low

427134

DLGP2
Disks large-associated protein 2

1

0

High-throughput

0.268

Low

427143

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

High-throughput

0.268

Low

427086

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

427131

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

309647

KAT7
Histone acetyltransferase KAT7

1

0

High-throughput

0.249

Low

427039

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

427044

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

427052

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

427059

DNLI4
DNA ligase 4

1

0

High-throughput

0.249

Low

427064

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

427084

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

427085

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

427088

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

427092

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

427094

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

427099

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

427103

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.249

Low

427104

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

427105

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low

427117

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.249

Low

427123

RANB3
Ran-binding protein 3

1

0

High-throughput

0.249

Low

427125

ANLN
Anillin

1

0

High-throughput

0.249

Low

427129

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

427130

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

427135

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

427139

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

427141

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

239715

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024