Protein: GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9)

Gene: GPX4
Organism: Homo sapiens
Interactions: 69
UniProt ID: P36969

Gene Ontology (top 5):
GO:0004602 - glutathione peroxidase activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788327

OTUB1
Ubiquitin thioesterase OTUB1

3

0

Small-scale

0.606

High

788329

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

1

Small-scale

0.584

High

733836

CDD
Cytidine deaminase

2

0

High-throughput

0.576

High

788325

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

Small-scale

0.561

High

788304

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.536

High

788309

CYTM
Cystatin-M

1

1

High-throughput

0.536

High

788317

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

788335

GSTO2
Glutathione S-transferase omega-2

1

2

High-throughput

0.536

High

184596

MK13
Mitogen-activated protein kinase 13

1

0

High-throughput

0.518

High

656056

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.515

High

788294

OMP
Olfactory marker protein

1

0

High-throughput

0.513

High

788328

OTUD5
OTU domain-containing protein 5

1

0

High-throughput

0.513

High

788330

GPA33
Cell surface A33 antigen

1

0

High-throughput

0.513

High

788336

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.513

High

788308

IL18
Interleukin-18

1

0

High-throughput

0.493

High

788322

RPE
Ribulose-phosphate 3-epimerase

1

0

High-throughput

0.493

High

788295

CY561
Transmembrane ascorbate-dependent reductase CYB561

1

3

High-throughput

0.489

High

788315

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

1

High-throughput

0.489

High

716251

PRDX6
Peroxiredoxin-6

1

2

High-throughput

0.481

High

190838

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

341534

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

623158

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.479

High

788300

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

2

High-throughput

0.479

High

788303

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

Small-scale

0.479

High

788314

UBP31
Ubiquitin carboxyl-terminal hydrolase 31

1

1

Small-scale

0.479

High

788316

TAXB1
Tax1-binding protein 1

1

2

Small-scale

0.479

High

788321

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

1

High-throughput

0.479

High

788312

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.460

High

188651

BIRC5
Baculoviral IAP repeat-containing protein 5

1

0

Small-scale

0.458

High

240935

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

788293

COIL
Coilin

1

0

High-throughput

0.458

High

788296

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

788297

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

788298

H31
Histone H3.1

1

0

High-throughput

0.458

High

788299

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

788306

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

788307

CUL3
Cullin-3

1

0

High-throughput

0.458

High

788311

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.458

High

788333

SHRPN
Sharpin

1

0

Small-scale

0.458

High

388161

GLPA
Glycophorin-A

1

1

High-throughput

0.445

High

529238

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

622035

CD53
Leukocyte surface antigen CD53

1

3

High-throughput

0.445

High

720736

PUR8
Adenylosuccinate lyase

1

2

High-throughput

0.445

High

788326

LRC46
Leucine-rich repeat-containing protein 46

1

2

High-throughput

0.445

High

788331

HIRP3
HIRA-interacting protein 3

1

1

High-throughput

0.445

High

788332

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

1

High-throughput

0.445

High

788338

DBNL
Drebrin-like protein

1

2

High-throughput

0.445

High

788339

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

370164

CYTN
Cystatin-SN

1

1

Small-scale

0.437

High

640656

ZP3
Zona pellucida sperm-binding protein 3

1

2

Small-scale

0.437

High

788301

ZP2
Zona pellucida sperm-binding protein 2

1

2

Small-scale

0.437

High

788302

ZP4
Zona pellucida sperm-binding protein 4

1

2

Small-scale

0.437

High

788313

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

788318

TRI59
Tripartite motif-containing protein 59

1

2

Small-scale

0.437

High

788334

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

788340

TRI17
E3 ubiquitin-protein ligase TRIM17

1

1

Small-scale

0.437

High

341907

CEP43
Centrosomal protein 43

1

0

High-throughput

0.426

High

429424

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

653169

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

788305

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

788320

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.426

High

64172

ARG35
Rho guanine nucleotide exchange factor 35

1

1

High-throughput

0.407

High

330064

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

788310

LRC73
Leucine-rich repeat-containing protein 73

1

1

High-throughput

0.407

High

158602

VCY1
Testis-specific basic protein Y 1

1

0

High-throughput

0.279

Low

788337

FLOWR
Calcium channel flower homolog

1

0

High-throughput

0.279

Low

788319

CI040
Uncharacterized protein C9orf40

1

0

High-throughput

0.232

Low

788323

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.232

Low

788324

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025