HitPredict

Interactor 1: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.885

The method score is based on:

Property Details
Experiments 15001576, 11343802, 15572679, 14743216
Identification Methods enzymatic study, in-gel kinase assay, tandem affinity purification
Interaction Type direct interaction, phosphorylation reaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PB1~PB1, PB1~Pkinase, Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0001568 - blood vessel development
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
and 12 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 626
Hs

1 626
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Last updated: 15 Jul 2024