Protein: IDE
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)

Gene: IDE
Organism: Homo sapiens
Interactions: 163
UniProt ID: P14735

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001618 - virus receptor activity
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575106

IDE
Insulin-degrading enzyme

3

10

Small-scale

0.840

High

377392

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

2

0

Small-scale

0.761

High

377815

IGF2
Insulin-like growth factor 2

2

3

Small-scale

0.755

High

575117

HXC9
Homeobox protein Hox-C9

4

2

High-throughput

0.691

High

575124

NEST
Nestin

3

13

Small-scale

0.670

High

575183

VWCE
von Willebrand factor C and EGF domain-containing protein

3

2

High-throughput

0.662

High

575226

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

3

8

Small-scale

0.650

High

420271

IGF1
Insulin-like growth factor 1

1

2

Small-scale

0.647

High

575186

HYLS1
Centriolar and ciliogenesis-associated protein HYLS1

3

0

High-throughput

0.638

High

575195

DOHH
Deoxyhypusine hydroxylase

3

0

High-throughput

0.638

High

421429

A4
Amyloid-beta precursor protein

2

2

Small-scale

0.635

High

575224

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

3

0

High-throughput

0.634

High

474445

VIME
Vimentin

2

11

High-throughput

0.628

High

575130

ISK7
Serine protease inhibitor Kazal-type 7

2

6

High-throughput

0.628

High

575176

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

4

High-throughput

0.628

High

575129

CCL23
C-C motif chemokine 23

2

4

High-throughput

0.612

High

388038

MBP
Myelin basic protein

2

0

High-throughput

0.602

High

409556

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

0

High-throughput

0.602

High

575151

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.602

High

575152

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.602

High

575184

ARSG
Arylsulfatase G

2

0

High-throughput

0.602

High

575197

PHF7
E3 ubiquitin-protein ligase PHF7

2

0

High-throughput

0.602

High

575217

TINAG
Tubulointerstitial nephritis antigen

2

0

High-throughput

0.602

High

403792

GCR
Glucocorticoid receptor

2

4

Small-scale

0.595

High

575167

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

0

High-throughput

0.585

High

575123

SOX2
Transcription factor SOX-2

2

2

High-throughput

0.584

High

575133

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.584

High

575139

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

456936

CO8A
Complement component C8 alpha chain

2

0

High-throughput

0.576

High

575185

LURA1
Leucine rich adaptor protein 1

2

0

High-throughput

0.576

High

575201

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.576

High

575109

ISK2
Serine protease inhibitor Kazal-type 2

2

3

High-throughput

0.574

High

507486

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.568

High

518801

CCL3
C-C motif chemokine 3

1

4

Small-scale

0.568

High

534550

IAPP
Islet amyloid polypeptide

1

1

Small-scale

0.568

High

575218

NSF1C
NSFL1 cofactor p47

2

0

Small-scale

0.559

High

575188

MIA2
Melanoma inhibitory activity protein 2

3

3

High-throughput

0.558

High

377275

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

0

Small-scale

0.544

High

133075

FOXE1
Forkhead box protein E1

1

2

High-throughput

0.536

High

438925

CD5
T-cell surface glycoprotein CD5

1

3

High-throughput

0.536

High

451116

NFL
Neurofilament light polypeptide

1

11

High-throughput

0.536

High

570347

GFAP
Glial fibrillary acidic protein

1

11

High-throughput

0.536

High

575108

CL3L1
C-C motif chemokine 3-like 1

1

4

High-throughput

0.536

High

575116

HXC8
Homeobox protein Hox-C8

1

1

High-throughput

0.536

High

575132

DEFB1
Beta-defensin 1

1

2

High-throughput

0.536

High

575135

AMPD2
AMP deaminase 2

1

1

High-throughput

0.536

High

575138

AINX
Alpha-internexin

1

11

High-throughput

0.536

High

575140

KR132
Keratin-associated protein 13-2

1

3

High-throughput

0.536

High

575146

PRR27
Proline-rich protein 27

1

3

High-throughput

0.536

High

575153

YTHD3
YTH domain-containing family protein 3

1

2

High-throughput

0.536

High

575154

NEK8
Serine/threonine-protein kinase Nek8

1

2

High-throughput

0.536

High

575159

EGFL6
Epidermal growth factor-like protein 6

1

3

High-throughput

0.536

High

575161

CDKL3
Cyclin-dependent kinase-like 3

1

1

High-throughput

0.536

High

575170

G45IP
Large ribosomal subunit protein mL64

1

2

High-throughput

0.536

High

575171

BRSK1
Serine/threonine-protein kinase BRSK1

1

3

High-throughput

0.536

High

575198

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

1

High-throughput

0.536

High

575212

DKK4
Dickkopf-related protein 4

1

1

High-throughput

0.536

High

575219

SCAF8
SR-related and CTD-associated factor 8

1

2

High-throughput

0.536

High

575225

TNR18
Tumor necrosis factor receptor superfamily member 18

1

1

High-throughput

0.536

High

575227

RM42
Large ribosomal subunit protein mL42

1

2

High-throughput

0.536

High

575229

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.536

High

131545

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

0

High-throughput

0.513

High

298485

SPF30
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.513

High

575110

SIAL
Integrin-binding sialoprotein

1

0

High-throughput

0.513

High

575115

AVR2A
Activin receptor type-2A

1

0

High-throughput

0.513

High

575119

CHKA
Choline kinase alpha

1

0

High-throughput

0.513

High

575122

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

575128

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

575155

ILDR1
Immunoglobulin-like domain-containing receptor 1

1

0

High-throughput

0.513

High

575172

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

0

High-throughput

0.513

High

575173

DCNP1
Dendritic cell nuclear protein 1

1

0

High-throughput

0.513

High

575177

GATA6
Transcription factor GATA-6

1

0

High-throughput

0.513

High

575196

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

575213

DUX4
Double homeobox protein 4

1

0

High-throughput

0.513

High

575216

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

519706

ANDR
Androgen receptor

1

4

Small-scale

0.501

High

575223

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.501

High

418813

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.493

High

451324

NFM
Neurofilament medium polypeptide

1

12

High-throughput

0.489

High

575145

ISK14
Serine protease inhibitor Kazal-type 14

1

2

High-throughput

0.489

High

575214

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.489

High

124574

EYA2
Protein phosphatase EYA2

1

1

High-throughput

0.479

High

214251

LYRM1
LYR motif-containing protein 1

1

2

High-throughput

0.479

High

240650

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

274973

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.479

High

284537

ECI2
Enoyl-CoA delta isomerase 2

1

5

High-throughput

0.479

High

316739

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.479

High

411291

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

413116

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

505411

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

4

High-throughput

0.479

High

575107

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

575112

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

7

High-throughput

0.479

High

575114

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

11

High-throughput

0.479

High

575134

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

575136

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

575137

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

575143

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

575148

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

575150

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

5

High-throughput

0.479

High

575157

NIT1
Deaminated glutathione amidase

1

3

High-throughput

0.479

High

575158

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.479

High

575164

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

3

High-throughput

0.479

High

575174

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.479

High

575175

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

575181

CHCH1
Small ribosomal subunit protein mS37

1

2

High-throughput

0.479

High

575191

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

575199

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

3

High-throughput

0.479

High

575202

OPA3
Optic atrophy 3 protein

1

1

High-throughput

0.479

High

575204

LYRM4
LYR motif-containing protein 4

1

4

High-throughput

0.479

High

575205

XPP3
Xaa-Pro aminopeptidase 3

1

3

High-throughput

0.479

High

575207

MTMRA
Myotubularin-related protein 10

1

1

High-throughput

0.479

High

575208

PAK5
Serine/threonine-protein kinase PAK 5

1

8

High-throughput

0.479

High

575215

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

575222

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

575228

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

5

High-throughput

0.479

High

575147

DLK2
Protein delta homolog 2

1

2

High-throughput

0.470

High

536419

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

575120

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

575165

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

575182

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

575192

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

575203

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

429233

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

561019

CCL4
C-C motif chemokine 4

1

4

Small-scale

0.445

High

575111

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

1

High-throughput

0.445

High

575126

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.445

High

575127

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.445

High

575141

S27A3
Long-chain fatty acid transport protein 3

1

2

High-throughput

0.445

High

575142

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

575144

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

575189

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

575193

PKP2
Plakophilin-2

1

1

High-throughput

0.445

High

575220

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.445

High

575118

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

457033

CAN1
Calpain-1 catalytic subunit

1

0

High-throughput

0.426

High

575113

PROZ
Vitamin K-dependent protein Z

1

0

High-throughput

0.426

High

575121

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.426

High

575156

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.426

High

575166

NOA1
Nitric oxide-associated protein 1

1

0

High-throughput

0.426

High

575168

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

1

0

High-throughput

0.426

High

575178

GPKOW
G-patch domain and KOW motifs-containing protein

1

0

High-throughput

0.426

High

575179

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

High-throughput

0.426

High

575180

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.426

High

575190

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.426

High

575206

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.426

High

575211

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.426

High

575221

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.426

High

575125

PEX5
Peroxisomal targeting signal 1 receptor

1

3

Small-scale

0.408

High

261073

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

575200

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

575160

P3H3
Prolyl 3-hydroxylase 3

2

0

High-throughput

0.328

High

575149

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.289

High

504683

F163B
Protein FAM163B

1

0

High-throughput

0.279

Low

575131

PROK1
Prokineticin-1

1

0

High-throughput

0.279

Low

575162

D107A
Beta-defensin 107

1

0

High-throughput

0.279

Low

575163

H6ST3
Heparan-sulfate 6-O-sulfotransferase 3

1

0

High-throughput

0.279

Low

575169

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

575210

GALP
Galanin-like peptide

1

0

High-throughput

0.279

Low

575187

CF195
Uncharacterized protein encoded by LINC01600

1

0

High-throughput

0.269

Low

165791

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

0

High-throughput

0.232

Low

575194

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.232

Low

575209

VGLU2
Vesicular glutamate transporter 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025