HitPredict

Interactor 1: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_2~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 1731
+	Hs
		1307450 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		1115943 SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		1052307 SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1089308 RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1045505 SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		82760 B9EKJ1_MOUSE (4-349): 1.05e-36: 143: 16.06		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		561160 SPTN1_MOUSE (4-349): 1.15e-36: 142: 16.06		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Rn
		555260 SPTN1_RAT (4-349): 1.18e-36: 142: 16.06		SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31
+	Rn
		1337443 DBNL_RAT (26-348): 1.37e-35: 136: 15.03		SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31
+	Mm
		1115913 GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		1052351 SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		167009 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		862039 SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Hs
		862037 SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Mm
		82740 B9EKJ1_MOUSE (4-349): 1.05e-36: 143: 16.06		ANK3_MOUSE (120-691): 8.6e-55: 214: 14.98
+	Hs
		965102 SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		1021399 SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		924484 GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		1045573 SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06		SHAN1_HUMAN (320-1726): 3.34e-22: 107: 13.60
+	Mm
		561172 SPTN1_MOUSE (4-349): 1.15e-36: 142: 16.06		ANK2_MOUSE (134-336): 2.34e-09: 65.1: 29.56