Protein: FBXW5
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)

Gene: FBXW5
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q969U6

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007088 - regulation of mitotic nuclear division
GO:0010824 - regulation of centrosome duplication
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992292

SKP1
S-phase kinase-associated protein 1

17

1

Small-scale

0.985

High

1112646

CUL1
Cullin-1

9

4

Small-scale

0.968

High

1114987

CUL4A
Cullin-4A

4

4

Small-scale

0.881

High

1157851

DDB1
DNA damage-binding protein 1

4

1

Small-scale

0.878

High

1349261

WDR20
WD repeat-containing protein 20

4

0

High-throughput

0.853

High

610815

TCPA
T-complex protein 1 subunit alpha

2

3

High-throughput

0.789

High

821493

TCPZ
T-complex protein 1 subunit zeta

2

4

High-throughput

0.789

High

1007189

TCPB
T-complex protein 1 subunit beta

2

4

High-throughput

0.789

High

1381297

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

1

High-throughput

0.783

High

882078

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.691

High

1103642

PHLP
Phosducin-like protein

1

1

High-throughput

0.691

High

1112947

CUL2
Cullin-2

1

4

High-throughput

0.691

High

1115345

CUL4B
Cullin-4B

1

4

High-throughput

0.691

High

1208943

DCA10
DDB1- and CUL4-associated factor 10

1

1

High-throughput

0.691

High

1363665

TCPW
T-complex protein 1 subunit zeta-2

1

5

High-throughput

0.691

High

1381264

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.691

High

950615

KR108
Keratin-associated protein 10-8

3

9

High-throughput

0.675

High

1146086

K1H1
Keratin, type I cuticular Ha1

3

3

High-throughput

0.675

High

331782

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.656

High

618475

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

0

High-throughput

0.656

High

1085513

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

High-throughput

0.656

High

1135031

CUL7
Cullin-7

1

0

High-throughput

0.656

High

1153210

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.656

High

1181488

EMAL3
Echinoderm microtubule-associated protein-like 3

1

0

High-throughput

0.656

High

1245318

WDR59
GATOR2 complex protein WDR59

1

0

High-throughput

0.656

High

1327576

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.656

High

1349721

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.656

High

1381298

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.656

High

1381283

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.655

High

572111

TRI27
Zinc finger protein RFP

3

0

High-throughput

0.646

High

1336240

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

3

0

High-throughput

0.638

High

1381268

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.638

High

1277347

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.633

High

1381280

NDEL1
Nuclear distribution protein nudE-like 1

2

1

High-throughput

0.628

High

1258789

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.622

High

876106

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.618

High

1113925

CUL3
Cullin-3

1

4

Small-scale

0.618

High

300455

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.606

High

300676

KRT37
Keratin, type I cuticular Ha7

2

3

High-throughput

0.606

High

950856

KR109
Keratin-associated protein 10-9

2

10

High-throughput

0.606

High

1205917

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.606

High

1307432

KRA13
Keratin-associated protein 1-3

2

8

High-throughput

0.606

High

1381275

KRA93
Keratin-associated protein 9-3

2

9

High-throughput

0.606

High

1381276

KRA41
Keratin-associated protein 4-1

2

9

High-throughput

0.606

High

1179934

TXIP1
Translin-associated factor X-interacting protein 1

2

0

High-throughput

0.602

High

1381291

DCA13
DDB1- and CUL4-associated factor 13

1

0

Small-scale

0.586

High

890869

TSC2
Tuberin

2

1

Small-scale

0.584

High

949610

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.580

High

1149011

SC23B
Protein transport protein Sec23B

2

0

Small-scale

0.577

High

213987

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

0

Small-scale

0.576

High

259023

DNJA2
DnaJ homolog subfamily A member 2

2

0

High-throughput

0.576

High

1230183

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.573

High

1381274

KRA94
Keratin-associated protein 9-4

1

9

High-throughput

0.573

High

983925

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.569

High

1358425

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

2

0

Small-scale

0.559

High

351578

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

1

High-throughput

0.553

High

1022268

FBLN2
Fibulin-2

2

1

High-throughput

0.553

High

1180117

VWC2
Brorin

2

1

High-throughput

0.553

High

1381266

KR412
Keratin-associated protein 4-12

1

9

High-throughput

0.541

High

1248169

SAS6
Spindle assembly abnormal protein 6 homolog

1

0

Small-scale

0.537

High

155792

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.536

High

408125

TBB4A
Tubulin beta-4A chain

1

3

High-throughput

0.536

High

457604

TBB5
Tubulin beta chain

1

3

High-throughput

0.536

High

997071

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.536

High

1093393

TRI32
E3 ubiquitin-protein ligase TRIM32

1

2

High-throughput

0.536

High

1108655

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.536

High

1112260

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.536

High

1191924

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.536

High

1212818

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

1259401

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.536

High

1381267

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.536

High

1381271

AFG2B
ATPase family gene 2 protein homolog B

1

1

High-throughput

0.536

High

1381288

IF122
Intraflagellar transport protein 122 homolog

1

1

High-throughput

0.536

High

1381263

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

1364958

TSC1
Hamartin

1

1

Small-scale

0.515

High

325969

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.513

High

347225

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

537660

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

703018

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

984231

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

1154501

STXB2
Syntaxin-binding protein 2

1

0

High-throughput

0.513

High

1206999

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.513

High

1220714

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.513

High

1231944

MRCKG
Serine/threonine-protein kinase MRCK gamma

1

0

High-throughput

0.513

High

1244930

FOXR1
Forkhead box protein R1

1

0

High-throughput

0.513

High

1246911

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.513

High

1322263

FCSK
L-fucose kinase

1

0

High-throughput

0.513

High

1339313

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

1381257

CANB2
Calcineurin subunit B type 2

1

0

High-throughput

0.513

High

1381259

GCP6
Gamma-tubulin complex component 6

1

0

High-throughput

0.513

High

1381265

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1381269

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.513

High

1381273

BBS2
BBSome complex member BBS2

1

0

High-throughput

0.513

High

1381277

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.513

High

1381279

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.513

High

1381282

SAV1
Protein salvador homolog 1

1

0

High-throughput

0.513

High

1381284

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.513

High

1381285

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.513

High

1381290

CABP2
Calcium-binding protein 2

1

0

High-throughput

0.513

High

1381292

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.513

High

1381300

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

1381302

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.513

High

1186788

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

1381260

IF140
Intraflagellar transport protein 140 homolog

1

1

High-throughput

0.489

High

407678

S100B
Protein S100-B

1

0

High-throughput

0.486

High

949961

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.481

High

1059711

KRA11
Keratin-associated protein 1-1

1

8

High-throughput

0.481

High

1094394

CSN1
COP9 signalosome complex subunit 1

1

0

Small-scale

0.479

High

1381270

CSN4
COP9 signalosome complex subunit 4

1

0

Small-scale

0.479

High

136118

PLK4
Serine/threonine-protein kinase PLK4

1

1

Small-scale

0.479

High

144309

ACACB
Acetyl-CoA carboxylase 2

1

2

High-throughput

0.479

High

346674

TTC4
Tetratricopeptide repeat protein 4

1

2

High-throughput

0.479

High

349190

LATS1
Serine/threonine-protein kinase LATS1

1

1

Small-scale

0.479

High

425833

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.479

High

425941

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.479

High

461787

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468669

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

547186

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.479

High

895944

F10A1
Hsc70-interacting protein

1

1

High-throughput

0.479

High

1086889

CDC20
Cell division cycle protein 20 homolog

1

1

Small-scale

0.479

High

1308568

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1358080

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

1381262

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1381289

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.479

High

1381293

AKA7G
A-kinase anchor protein 7 isoform gamma

1

1

High-throughput

0.479

High

1381299

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

517079

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

598

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.460

High

124823

AIP
AH receptor-interacting protein

1

0

High-throughput

0.458

High

173179

XPO1
Exportin-1

1

0

High-throughput

0.458

High

182169

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.458

High

480876

LEG1
Galectin-1

1

0

High-throughput

0.458

High

519412

MYB
Transcriptional activator Myb

1

0

Small-scale

0.458

High

587762

DESP
Desmoplakin

1

0

High-throughput

0.458

High

637671

FLNA
Filamin-A

1

0

High-throughput

0.458

High

916698

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

991077

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

1095291

REST
RE1-silencing transcription factor

1

0

Small-scale

0.458

High

1157711

CSRP2
Cysteine and glycine-rich protein 2

1

0

High-throughput

0.458

High

1257745

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.458

High

1288879

NOXA1
NADPH oxidase activator 1

1

0

High-throughput

0.458

High

1357508

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1371175

GLMN
Glomulin

1

0

High-throughput

0.458

High

1381258

RHG07
Rho GTPase-activating protein 7

1

0

Small-scale

0.458

High

1381261

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

1381286

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.458

High

1381287

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1381296

NLK
Serine/threonine-protein kinase NLK

1

0

Small-scale

0.458

High

485316

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.426

High

1329722

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.426

High

1340184

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

224426

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.407

High

1337406

SRFB1
Serum response factor-binding protein 1

4

0

High-throughput

0.360

High

1250279

ATL4
ADAMTS-like protein 4

3

0

High-throughput

0.352

High

1187327

CMA1D
Protein CIMAP1D

3

0

High-throughput

0.347

High

451427

NFM
Neurofilament medium polypeptide

3

0

High-throughput

0.345

High

948735

DEFB1
Beta-defensin 1

2

0

High-throughput

0.328

High

70406

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

60646

CI170
Uncharacterized protein encoded by LINC02872

1

0

High-throughput

0.279

Low

1090360

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

Small-scale

0.279

Low

1178941

WASC4
WASH complex subunit 4

1

0

High-throughput

0.279

Low

1225960

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1241231

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.279

Low

1252853

ZN704
Zinc finger protein 704

1

0

High-throughput

0.279

Low

1293445

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.279

Low

1316620

CDK20
Cyclin-dependent kinase 20

1

0

High-throughput

0.279

Low

1381272

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

1381278

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

1381281

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1381294

ZNFX1
NFX1-type zinc finger-containing protein 1

1

0

High-throughput

0.279

Low

1381301

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.279

Low

1364807

F168A
Protein FAM168A

1

0

High-throughput

0.265

Low

756002

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.249

Low

1142354

PDIA6
Protein disulfide-isomerase A6

1

0

High-throughput

0.249

Low

1381295

NYNRI
Protein NYNRIN

1

0

High-throughput

0.249

Low

854563

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025