HitPredict - High confidence protein-protein interactions

Interactor 1: NAMPT (Q99KQ4)
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin)
Gene: NAMPT

Interactor 2: NAMPT (Q99KQ4)
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin)
Gene: NAMPT

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	16783373, 16783377
Identification Methods	x-ray crystallography, molecular sieving, light scattering
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	NAMPT_N~NAPRTase, NAPRTase~NAPRTase
Common GO terms	GO:0000166 - nucleotide binding GO:0001774 - microglial cell activation GO:0005125 - cytokine activity GO:0005615 - extracellular space GO:0005737 - cytoplasm and 14 others more... GO:0005829 - cytosol GO:0007623 - circadian rhythm GO:0009435 - NAD biosynthetic process GO:0010507 - negative regulation of autophagy GO:0014916 - regulation of lung blood pressure GO:0016607 - nuclear speck GO:0030054 - cell junction GO:0032922 - circadian regulation of gene expression GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0047280 - nicotinamide phosphoribosyltransferase activity GO:0048661 - positive regulation of smooth muscle cell proliferation GO:0051770 - positive regulation of nitric-oxide synthase biosynthetic process GO:1901363 - heterocyclic compound binding GO:2000773 - negative regulation of cellular senescence
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	491
Mm

1	491

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Last updated: 15 Jul 2024