Protein: RNF41
E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)

Gene: RNF41
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9H4P4

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005128 - erythropoietin receptor binding
GO:0005135 - interleukin-3 receptor binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

828253

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

5

20

Small-scale

0.930

High

1434402

RNF41
E3 ubiquitin-protein ligase NRDP1

5

19

Small-scale

0.923

High

1434409

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

4

20

Small-scale

0.899

High

242927

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.812

High

931598

RD23A
UV excision repair protein RAD23 homolog A

2

20

High-throughput

0.783

High

957670

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

957199

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

1434412

ASB6
Ankyrin repeat and SOCS box protein 6

9

6

Small-scale

0.759

High

1405802

TTC1
Tetratricopeptide repeat protein 1

10

8

Small-scale

0.757

High

1323343

VPS52
Vacuolar protein sorting-associated protein 52 homolog

8

4

Small-scale

0.757

High

1434418

ENOPH
Enolase-phosphatase E1

6

1

Small-scale

0.733

High

1434404

CYBP
Calcyclin-binding protein

4

4

Small-scale

0.702

High

1218763

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1382342

RN166
E3 ubiquitin-protein ligase RNF166

1

19

High-throughput

0.698

High

1434403

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1434411

HOME2
Homer protein homolog 2

4

10

Small-scale

0.696

High

230431

CREB3
Cyclic AMP-responsive element-binding protein 3

4

10

High-throughput

0.691

High

1102506

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

4

10

Small-scale

0.691

High

641673

ERBB3
Receptor tyrosine-protein kinase erbB-3

7

13

Small-scale

0.678

High

1434413

AIRIM
AFG2-interacting ribosome maturation factor

3

1

High-throughput

0.675

High

1178378

CL16A
Protein CLEC16A

3

4

High-throughput

0.675

High

281097

TACC1
Transforming acidic coiled-coil-containing protein 1

3

6

Small-scale

0.671

High

1434422

SGT1
Protein SGT1 homolog

3

10

Small-scale

0.667

High

1428792

SRR
Serine racemase

3

1

High-throughput

0.665

High

568174

PLSL
Plastin-2

3

12

High-throughput

0.662

High

769782

RFC4
Replication factor C subunit 4

5

3

Small-scale

0.658

High

1411295

LZTS2
Leucine zipper putative tumor suppressor 2

2

20

Small-scale

0.631

High

1135531

RHG19
Rho GTPase-activating protein 19

2

8

High-throughput

0.628

High

1252058

ZN517
Zinc finger protein 517

2

17

High-throughput

0.628

High

49346

SHOT1
Shootin-1

2

2

Small-scale

0.621

High

1226807

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

3

2

Small-scale

0.611

High

322867

MTCL2
Microtubule cross-linking factor 2

3

18

Small-scale

0.609

High

1145684

RCN1
Reticulocalbin-1

3

5

High-throughput

0.609

High

175992

N4BP3
NEDD4-binding protein 3

3

20

High-throughput

0.607

High

1273162

KDM3B
Lysine-specific demethylase 3B

2

6

Small-scale

0.606

High

991711

DYL1
Dynein light chain 1, cytoplasmic

2

6

High-throughput

0.601

High

1390716

DYL2
Dynein light chain 2, cytoplasmic

2

6

High-throughput

0.601

High

1145778

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

12

Small-scale

0.595

High

1273907

BHA15
Class A basic helix-loop-helix protein 15

2

1

High-throughput

0.574

High

1338110

NAV1
Neuron navigator 1

2

6

Small-scale

0.567

High

849080

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.561

High

943816

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

15

Small-scale

0.561

High

1394983

VCIP1
Deubiquitinating protein VCPIP1

2

1

Small-scale

0.558

High

1325119

MTURN
Maturin

2

4

High-throughput

0.553

High

1331103

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

4

High-throughput

0.553

High

1017208

H33
Histone H3.3

1

12

Small-scale

0.553

High

922610

AP2S1
AP-2 complex subunit sigma

1

4

Small-scale

0.552

High

1150487

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

14

High-throughput

0.549

High

1273230

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.549

High

908786

MAT1
CDK-activating kinase assembly factor MAT1

1

7

High-throughput

0.541

High

1093427

TRI32
E3 ubiquitin-protein ligase TRIM32

1

18

High-throughput

0.541

High

1407464

TS101
Tumor susceptibility gene 101 protein

1

4

High-throughput

0.541

High

1420181

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

19

High-throughput

0.541

High

249009

EVI5
Ecotropic viral integration site 5 protein homolog

1

5

High-throughput

0.536

High

517818

GLI4
Zinc finger protein GLI4

1

18

High-throughput

0.536

High

717999

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.536

High

920717

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.536

High

990732

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1096928

FADD
FAS-associated death domain protein

1

14

High-throughput

0.536

High

1143908

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

2

High-throughput

0.536

High

1180727

ZN284
Zinc finger protein 284

1

8

High-throughput

0.536

High

1217081

RAIN
Ras-interacting protein 1

1

14

High-throughput

0.536

High

1243720

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

20

High-throughput

0.536

High

1278218

CLAP1
CLIP-associating protein 1

1

5

High-throughput

0.536

High

1308548

ZN584
Zinc finger protein 584

1

20

High-throughput

0.536

High

1308803

NAV3
Neuron navigator 3

1

15

High-throughput

0.536

High

1369487

TANK
TRAF family member-associated NF-kappa-B activator

1

5

High-throughput

0.536

High

1396678

MARK4
MAP/microtubule affinity-regulating kinase 4

1

8

High-throughput

0.536

High

1431124

REN3A
Regulator of nonsense transcripts 3A

1

1

High-throughput

0.536

High

1434415

ITSN2
Intersectin-2

1

9

High-throughput

0.536

High

1434417

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

20

High-throughput

0.536

High

1434425

SNCAP
Synphilin-1

1

14

High-throughput

0.536

High

1346642

VANG1
Vang-like protein 1

2

2

Small-scale

0.533

High

1434423

MTCL1
Microtubule cross-linking factor 1

2

12

Small-scale

0.533

High

75536

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

465648

IGF1R
Insulin-like growth factor 1 receptor

2

16

Small-scale

0.521

High

123441

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.513

High

568589

TNNT1
Troponin T, slow skeletal muscle

1

0

High-throughput

0.513

High

1388070

RTP4
Receptor-transporting protein 4

1

0

High-throughput

0.513

High

1270525

MARK2
Serine/threonine-protein kinase MARK2

1

9

Small-scale

0.512

High

1353533

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

15

Small-scale

0.512

High

458484

ADRB2
Beta-2 adrenergic receptor

1

4

Small-scale

0.504

High

423163

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

869791

MTR1A
Melatonin receptor type 1A

1

4

High-throughput

0.494

High

880963

MTR1B
Melatonin receptor type 1B

1

4

High-throughput

0.494

High

686650

ELAV4
ELAV-like protein 4

1

16

High-throughput

0.489

High

1326622

KLH36
Kelch-like protein 36

1

2

High-throughput

0.489

High

1327405

DCLK2
Serine/threonine-protein kinase DCLK2

1

11

High-throughput

0.489

High

1365413

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

2

High-throughput

0.489

High

1389754

C1GLC
C1GALT1-specific chaperone 1

1

1

High-throughput

0.489

High

1415230

KIFC3
Kinesin-like protein KIFC3

1

8

High-throughput

0.489

High

160621

IRS4
Insulin receptor substrate 4

1

2

Small-scale

0.481

High

159856

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

9

Small-scale

0.479

High

213248

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

Small-scale

0.479

High

283545

TAD2A
Transcriptional adapter 2-alpha

1

3

High-throughput

0.479

High

334318

TACC2
Transforming acidic coiled-coil-containing protein 2

1

10

Small-scale

0.479

High

401478

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

15

High-throughput

0.479

High

439846

INSR
Insulin receptor

1

16

Small-scale

0.479

High

520375

ANDR
Androgen receptor

1

13

Small-scale

0.479

High

637733

FLNA
Filamin-A

1

12

Small-scale

0.479

High

643562

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

4

Small-scale

0.479

High

855753

CRK
Adapter molecule crk

1

20

Small-scale

0.479

High

862706

UTRN
Utrophin

1

12

Small-scale

0.479

High

900158

FXR1
RNA-binding protein FXR1

1

13

Small-scale

0.479

High

900510

FXR2
RNA-binding protein FXR2

1

13

Small-scale

0.479

High

908858

NEK2
Serine/threonine-protein kinase Nek2

1

15

Small-scale

0.479

High

956006

RAB8A
Ras-related protein Rab-8A

1

6

Small-scale

0.479

High

1056973

FMR1
Fragile X messenger ribonucleoprotein 1

1

13

Small-scale

0.479

High

1068310

AHNK
Neuroblast differentiation-associated protein AHNAK

1

4

Small-scale

0.479

High

1114296

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1150820

SF01
Splicing factor 1

1

10

High-throughput

0.479

High

1286796

KAISO
Transcriptional regulator Kaiso

1

20

Small-scale

0.479

High

1290347

SERC5
Serine incorporator 5

1

4

Small-scale

0.479

High

1295214

HOME1
Homer protein homolog 1

1

16

Small-scale

0.479

High

1309495

CEP97
Centrosomal protein of 97 kDa

1

5

Small-scale

0.479

High

1316453

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.479

High

1411024

COR1B
Coronin-1B

1

12

Small-scale

0.479

High

1434407

RTN4
Reticulon-4

1

3

Small-scale

0.479

High

1434408

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

8

High-throughput

0.479

High

1434410

DBLOH
Diablo IAP-binding mitochondrial protein

1

2

Small-scale

0.479

High

1434416

CTNL1
Alpha-catulin

1

2

Small-scale

0.479

High

1434421

ZN281
Zinc finger protein 281

1

12

Small-scale

0.479

High

244606

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

3

Small-scale

0.470

High

2871

A0A0C4DG62
ADP-ribosylation factor-like protein 6-interacting protein 4

1

2

High-throughput

0.470

High

1232576

Q6FHY5
MEOX2 protein

1

20

High-throughput

0.470

High

167649

GIPC1
PDZ domain-containing protein GIPC1

1

0

Small-scale

0.458

High

1250000

CLC9A
C-type lectin domain family 9 member A

1

1

Small-scale

0.457

High

1055095

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

13

High-throughput

0.457

High

1352984

CE192
Centrosomal protein of 192 kDa

1

2

High-throughput

0.445

High

871486

LEPR
Leptin receptor

1

10

Small-scale

0.439

High

894165

MEOX2
Homeobox protein MOX-2

1

20

High-throughput

0.439

High

1214913

WLS
Protein wntless homolog

1

0

Small-scale

0.438

High

657684

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.437

High

1216334

IFFO2
Intermediate filament family orphan 2

1

20

Small-scale

0.437

High

1217198

RIF1
Telomere-associated protein RIF1

1

4

Small-scale

0.437

High

1253940

FA83H
Protein FAM83H

1

1

Small-scale

0.437

High

1432578

CPVL
Probable serine carboxypeptidase CPVL

1

2

Small-scale

0.437

High

1433883

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1434405

Q9HCK3
KIAA1569 protein

1

2

High-throughput

0.437

High

1434414

DJB12
DnaJ homolog subfamily B member 12

1

3

Small-scale

0.437

High

1434419

MRTFB
Myocardin-related transcription factor B

1

8

Small-scale

0.437

High

1434420

VANG2
Vang-like protein 2

1

2

Small-scale

0.437

High

1434424

CD2AP
CD2-associated protein

1

18

Small-scale

0.437

High

1023887

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

1104933

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.426

High

116435

H7BXG1
C-type lectin domain containing 16A

1

4

High-throughput

0.407

High

1287732

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

5

0

Small-scale

0.377

High

1434406

IL23A
Interleukin-23 subunit alpha

3

0

High-throughput

0.347

High

485954

GIP
Gastric inhibitory polypeptide

2

0

High-throughput

0.328

High

567081

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

1124132

NPAT
Protein NPAT

1

0

High-throughput

0.279

Low

635913

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

Small-scale

0.249

Low

1358752

FACR1
Fatty acyl-CoA reductase 1

1

0

Small-scale

0.249

Low

116493

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025