HitPredict

Interactor 1: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Interactor 2: AGO4 (Q9HCK5)
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
Gene: AGO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19167051
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 342 Hs			1 861
+	Hs
		1309311 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		AGO1_HUMAN (8-861): 0: 1157: 83.49
+	Hs
		1309310 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		AGO2_HUMAN (12-861): 0: 1151: 78.94
+	Hs
		1309285 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		AGO3_HUMAN (5-861): 0: 1146: 81.18
+	Hs
		725607 COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38		AGO2_HUMAN (12-861): 0: 1151: 78.94
+	Hs
		725563 COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38		AGO3_HUMAN (5-861): 0: 1146: 81.18
+	Ce
		108523 COPB2_CAEEL (117-323): 2.2e-20: 94.1: 18.10		G5EGR6_CAEEL (13-861): 0: 1072: 64.77