Protein: SNX2
Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)

Gene: SNX2
Organism: Homo sapiens
Interactions: 180
UniProt ID: O60749

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

255500

SNX6
Sorting nexin-6

7

19

Small-scale

0.963

High

255421

SNX1
Sorting nexin-1

5

19

Small-scale

0.926

High

255447

SNX32
Sorting nexin-32

4

19

High-throughput

0.902

High

255502

DYN3
Dynamin-3

3

13

High-throughput

0.861

High

255509

SNX5
Sorting nexin-5

2

19

High-throughput

0.793

High

255351

SNX4
Sorting nexin-4

2

19

Small-scale

0.789

High

255345

SNX2
Sorting nexin-2

2

19

Small-scale

0.743

High

255352

VAPB
Vesicle-associated membrane protein-associated protein B/C

4

3

High-throughput

0.691

High

255408

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

4

2

High-throughput

0.691

High

255455

CAST3
Putative protein CASTOR3P

3

1

High-throughput

0.667

High

255399

DYN2
Dynamin-2

1

13

High-throughput

0.665

High

255474

FNBP1
Formin-binding protein 1

2

8

Small-scale

0.640

High

255434

HENMT
Small RNA 2'-O-methyltransferase

2

1

High-throughput

0.628

High

255462

DYT2B
Dynein light chain Tctex-type protein 2B

2

1

High-throughput

0.628

High

156750

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.618

High

255483

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.618

High

61839

F221A
Protein FAM221A

3

2

High-throughput

0.609

High

255433

TRML2
Trem-like transcript 2 protein

3

1

High-throughput

0.609

High

255454

CK042
Uncharacterized protein C11orf42

3

1

High-throughput

0.609

High

253032

PLIN3
Perilipin-3

2

2

High-throughput

0.606

High

255425

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

5

High-throughput

0.606

High

255461

TM239
Transmembrane protein 239

2

1

High-throughput

0.606

High

217592

TGON2
Trans-Golgi network integral membrane protein 2

2

8

High-throughput

0.588

High

240239

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

255354

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.584

High

255380

RAB4A
Ras-related protein Rab-4A

2

13

High-throughput

0.584

High

255410

RB11A
Ras-related protein Rab-11A

2

9

High-throughput

0.584

High

255420

MTM1
Myotubularin

2

4

High-throughput

0.584

High

255497

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.584

High

255442

CENPQ
Centromere protein Q

2

0

High-throughput

0.580

High

255475

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.580

High

255503

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.575

High

255453

CA087
Uncharacterized protein C1orf87

2

2

High-throughput

0.574

High

255358

CP1A1
Cytochrome P450 1A1

2

1

High-throughput

0.558

High

255349

YIF1A
Protein YIF1A

2

1

High-throughput

0.553

High

255493

VAPA
Vesicle-associated membrane protein-associated protein A

2

3

Small-scale

0.553

High

255371

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.552

High

255487

PAK6
Serine/threonine-protein kinase PAK 6

1

8

High-throughput

0.541

High

255512

DUS10
Dual specificity protein phosphatase 10

1

1

High-throughput

0.541

High

255347

DNJB6
DnaJ homolog subfamily B member 6

1

4

High-throughput

0.536

High

255367

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

5

High-throughput

0.536

High

255382

BMP6
Bone morphogenetic protein 6

1

3

High-throughput

0.536

High

255384

1433T
14-3-3 protein theta

1

7

High-throughput

0.536

High

255386

TPP2
Tripeptidyl-peptidase 2

1

1

High-throughput

0.536

High

255404

S12A3
Solute carrier family 12 member 3

1

3

High-throughput

0.536

High

255407

1433G
14-3-3 protein gamma

1

7

High-throughput

0.536

High

255414

1433F
14-3-3 protein eta

1

7

High-throughput

0.536

High

255435

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.536

High

255449

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

2

High-throughput

0.536

High

255460

PRUN2
Protein prune homolog 2

1

2

High-throughput

0.536

High

255476

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

255485

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

255490

KLHL1
Kelch-like protein 1

1

4

High-throughput

0.536

High

255496

DJB11
DnaJ homolog subfamily B member 11

1

2

High-throughput

0.536

High

255498

NRBP
Nuclear receptor-binding protein

1

3

High-throughput

0.536

High

255499

SPAT2
Spermatogenesis-associated protein 2

1

1

High-throughput

0.536

High

255506

WASC3
WASH complex subunit 3

1

1

High-throughput

0.536

High

255507

HYOU1
Hypoxia up-regulated protein 1

1

5

High-throughput

0.536

High

255510

SAR1B
Small COPII coat GTPase SAR1B

1

9

High-throughput

0.536

High

255359

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

255393

HD
Huntingtin

1

2

High-throughput

0.515

High

255353

CYB5
Cytochrome b5

1

0

High-throughput

0.513

High

255441

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.513

High

255508

TRI17
E3 ubiquitin-protein ligase TRIM17

1

0

High-throughput

0.513

High

49145

POTB3
POTE ankyrin domain family member B3

2

5

High-throughput

0.504

High

255430

SMN
Survival motor neuron protein

1

0

High-throughput

0.493

High

255459

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.493

High

155704

CUX2
Homeobox protein cut-like 2

1

3

High-throughput

0.489

High

255369

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

255417

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.489

High

255432

DB136
Defensin beta 136

1

3

High-throughput

0.489

High

255463

IBPL1
Insulin-like growth factor-binding protein-like 1

1

7

High-throughput

0.489

High

255505

NTNG1
Netrin-G1

1

6

High-throughput

0.489

High

255511

RM42
Large ribosomal subunit protein mL42

1

1

High-throughput

0.489

High

255411

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.481

High

189339

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

225879

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

255355

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

255356

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

255357

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

255360

K1C18
Keratin, type I cytoskeletal 18

1

1

High-throughput

0.479

High

255362

INSR
Insulin receptor

1

20

Small-scale

0.479

High

255363

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

255368

PGFRB
Platelet-derived growth factor receptor beta

1

16

Small-scale

0.479

High

255370

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

255373

FGFR1
Fibroblast growth factor receptor 1

1

14

High-throughput

0.479

High

255374

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

255375

LAMP2
Lysosome-associated membrane glycoprotein 2

1

15

High-throughput

0.479

High

255377

PGFRA
Platelet-derived growth factor receptor alpha

1

15

Small-scale

0.479

High

255379

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

5

High-throughput

0.479

High

255381

RAB5A
Ras-related protein Rab-5A

1

14

High-throughput

0.479

High

255383

FGFR4
Fibroblast growth factor receptor 4

1

15

High-throughput

0.479

High

255387

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

255388

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

255391

VGFR3
Vascular endothelial growth factor receptor 3

1

16

High-throughput

0.479

High

255394

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

255397

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

255398

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

255400

RAB5C
Ras-related protein Rab-5C

1

14

High-throughput

0.479

High

255401

RAB7A
Ras-related protein Rab-7a

1

18

High-throughput

0.479

High

255402

RAB9A
Ras-related protein Rab-9A

1

17

High-throughput

0.479

High

255409

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

255412

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

255413

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

255419

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

255422

AVR2B
Activin receptor type-2B

1

8

Small-scale

0.479

High

255427

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.479

High

255428

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.479

High

255429

T22D1
TSC22 domain family protein 1

1

2

High-throughput

0.479

High

255437

LTOR1
Ragulator complex protein LAMTOR1

1

8

High-throughput

0.479

High

255440

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

255443

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

255445

HOOK3
Protein Hook homolog 3

1

2

High-throughput

0.479

High

255456

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

255457

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

255458

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.479

High

255464

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

255465

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

255468

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

255470

AURKB
Aurora kinase B

1

7

High-throughput

0.479

High

255473

FMNL2
Formin-like protein 2

1

3

High-throughput

0.479

High

255477

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

255480

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

2

Small-scale

0.479

High

255482

DNJC5
DnaJ homolog subfamily C member 5

1

11

High-throughput

0.479

High

255484

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

255486

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

255491

ZDH18
Palmitoyltransferase ZDHHC18

1

2

Small-scale

0.479

High

255492

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

255494

ANFY1
Rabankyrin-5

1

6

High-throughput

0.479

High

255495

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

255504

LAMP3
Lysosome-associated membrane glycoprotein 3

1

15

High-throughput

0.479

High

255424

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.460

High

186961

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.458

High

255348

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

255366

K1C19
Keratin, type I cytoskeletal 19

1

0

High-throughput

0.458

High

255389

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.458

High

255423

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

255426

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

255431

FSCN1
Fascin

1

0

High-throughput

0.458

High

255478

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

248811

GSDME
Gasdermin-E

1

1

High-throughput

0.445

High

255361

HEPS
Serine protease hepsin

1

4

High-throughput

0.445

High

255378

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.445

High

255405

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

255416

WASC5
WASH complex subunit 5

1

1

High-throughput

0.445

High

255436

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

255438

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

255450

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.445

High

255452

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

255466

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.445

High

255488

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

255489

BIN3
Bridging integrator 3

1

7

High-throughput

0.445

High

255350

ZN202
Zinc finger protein 202

1

1

High-throughput

0.439

High

255376

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

255385

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

255390

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

255392

ACV1B
Activin receptor type-1B

1

8

Small-scale

0.437

High

255395

LEPR
Leptin receptor

1

4

Small-scale

0.437

High

255396

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

255403

EPHA5
Ephrin type-A receptor 5

1

19

High-throughput

0.437

High

255406

RAB25
Ras-related protein Rab-25

1

11

High-throughput

0.437

High

255415

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

5

High-throughput

0.437

High

255444

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

255446

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

255448

F90A1
Protein FAM90A1

1

3

High-throughput

0.437

High

255451

ZDH23
Palmitoyltransferase ZDHHC23

1

5

Small-scale

0.437

High

255467

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

255501

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

255469

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

255481

CENPH
Centromere protein H

1

0

High-throughput

0.426

High

255364

ACM4
Muscarinic acetylcholine receptor M4

1

4

High-throughput

0.407

High

255418

RM49
Large ribosomal subunit protein mL49

1

3

High-throughput

0.407

High

255479

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

255372

LAMC1
Laminin subunit gamma-1

1

0

High-throughput

0.251

Low

255439

CA122
Uncharacterized protein C1orf122

1

0

High-throughput

0.251

Low

255365

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

255471

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

255472

SFXN2
Sideroflexin-2

1

0

High-throughput

0.249

Low

255346

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025