HitPredict

Interactor 1: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 559
+	Hs
		1031490 PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61		PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00
+	Hs
		963985 SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1054669 PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1020258 ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1031328 PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1020321 SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		1288621 SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		1020353 PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		1020306 ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		1020292 ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45		CELF5_HUMAN (226-307): 1.82e-18: 90.2: 25.61
+	Hs
		516744 PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		1031413 PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		474019 ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45		PAB4L_HUMAN (479-559): 3.69e-14: 76.1: 20.99
+	Hs
		474021 PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61		PAB4L_HUMAN (479-559): 3.69e-14: 76.1: 20.99
+	Hs
		1020249 ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516484 ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		516495 PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		516339 PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64