Protein: P5CR3
Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)

Gene: P5CR3, PYCR3
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q53H96

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005829 - cytosol
GO:0042802 - identical protein binding
GO:0045171 - intercellular bridge
GO:0055129 - L-proline biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733940

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

3

14

High-throughput

0.861

High

1199934

P5CR2
Pyrroline-5-carboxylate reductase 2

3

14

High-throughput

0.861

High

1199905

P5CR3
Pyrroline-5-carboxylate reductase 3

1

14

High-throughput

0.698

High

140295

SDCB1
Syntenin-1

3

1

High-throughput

0.675

High

842922

CDN2B
Cyclin-dependent kinase 4 inhibitor B

3

1

Small-scale

0.653

High

679179

DNJB1
DnaJ homolog subfamily B member 1

3

2

High-throughput

0.650

High

643492

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

0

High-throughput

0.638

High

336683

BAG4
BAG family molecular chaperone regulator 4

2

1

High-throughput

0.606

High

1199930

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

1

High-throughput

0.601

High

1199942

CYH2
Cytohesin-2

2

2

High-throughput

0.601

High

1199955

DNJB4
DnaJ homolog subfamily B member 4

2

2

High-throughput

0.601

High

633701

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

1199938

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

981850

RL23
Large ribosomal subunit protein uL14

2

0

High-throughput

0.576

High

1199924

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

0

High-throughput

0.559

High

1199910

KLD10
Kelch domain-containing protein 10

2

1

High-throughput

0.549

High

1199935

KCD12
BTB/POZ domain-containing protein KCTD12

2

2

High-throughput

0.549

High

1199962

TRI33
E3 ubiquitin-protein ligase TRIM33

2

2

High-throughput

0.549

High

899945

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

900359

FXR2
RNA-binding protein FXR2

1

4

High-throughput

0.541

High

276692

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

1

High-throughput

0.536

High

927335

ATX1
Ataxin-1

1

2

High-throughput

0.536

High

1113273

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1124466

MAP7
Ensconsin

1

3

High-throughput

0.536

High

1142725

PDK2
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

1149052

CYH1
Cytohesin-1

1

2

High-throughput

0.536

High

1156506

CCDC6
Coiled-coil domain-containing protein 6

1

2

High-throughput

0.536

High

1199914

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

372206

MYC
Myc proto-oncogene protein

2

3

Small-scale

0.533

High

1199918

ZN687
Zinc finger protein 687

1

0

High-throughput

0.513

High

1199921

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.513

High

1199950

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

873366

AL3B2
Aldehyde dehydrogenase family 3 member B2

1

1

High-throughput

0.489

High

1142558

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.489

High

1199944

AASD1
Alanyl-tRNA editing protein Aarsd1

1

3

High-throughput

0.489

High

1199959

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

1

High-throughput

0.489

High

728278

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

241880

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

508084

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.479

High

942661

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

964999

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

1115705

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.479

High

1199923

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1199929

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1199931

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

1199943

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1199953

BABA1
BRISC and BRCA1-A complex member 1

1

1

High-throughput

0.479

High

1199961

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

1199957

KCNG1
Voltage-gated potassium channel regulatory subunit KCNG1

1

1

High-throughput

0.470

High

1199939

ANM6
Protein arginine N-methyltransferase 6

1

1

High-throughput

0.464

High

319814

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

786643

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

897291

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

970613

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1109785

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1199925

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

1199928

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.458

High

1199946

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

1199951

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

67679

RHG32
Rho GTPase-activating protein 32

1

1

High-throughput

0.445

High

225483

CYH3
Cytohesin-3

1

2

High-throughput

0.445

High

848029

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.445

High

1199908

ELP2
Elongator complex protein 2

1

1

High-throughput

0.445

High

1199927

LMO7
LIM domain only protein 7

1

1

High-throughput

0.445

High

1199937

AURKB
Aurora kinase B

1

2

High-throughput

0.445

High

1199954

RHG23
Rho GTPase-activating protein 23

1

2

High-throughput

0.445

High

176070

KDM6B
Lysine-specific demethylase 6B

1

2

Small-scale

0.437

High

293790

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

315660

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

406249

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

775135

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

879163

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1121246

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

1199907

TENS2
Tensin-2

1

1

High-throughput

0.437

High

1199911

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1199913

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1199933

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

1199940

UIMC1
BRCA1-A complex subunit RAP80

1

1

High-throughput

0.437

High

1199949

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

186213

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.426

High

327604

ELP1
Elongator complex protein 1

1

0

High-throughput

0.426

High

413959

P53
Cellular tumor antigen p53

1

0

Small-scale

0.426

High

1199915

ULK2
Serine/threonine-protein kinase ULK2

1

0

High-throughput

0.426

High

75546

B3KSP9
Alanyl-tRNA editing protein Aarsd1

1

3

High-throughput

0.407

High

260876

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.407

High

844933

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.407

High

903388

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

High-throughput

0.407

High

1199932

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.407

High

1186167

INAVA
Innate immunity activator protein

2

0

High-throughput

0.313

High

885270

HXA1
Homeobox protein Hox-A1

1

0

High-throughput

0.282

High

409579

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.279

Low

608284

EGLN
Endoglin

1

0

High-throughput

0.279

Low

770391

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

946309

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

1098897

KLRD1
Natural killer cells antigen CD94

1

0

High-throughput

0.279

Low

1199906

KLH26
Kelch-like protein 26

1

0

High-throughput

0.279

Low

1199912

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.279

Low

1199916

MICU2
Calcium uptake protein 2, mitochondrial

1

0

High-throughput

0.279

Low

1199917

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1199920

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

0

High-throughput

0.279

Low

1199936

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

1199941

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

1199945

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1199947

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

1199960

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

1199963

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

613899

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.251

Low

246642

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

324914

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

377595

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1135699

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1186102

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

1199922

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.249

Low

1199948

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1199958

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low

1199964

SNX11
Sorting nexin-11

1

0

High-throughput

0.249

Low

191992

CAN5
Calpain-5

1

0

High-throughput

0.232

Low

244978

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

600502

ZNF3
Zinc finger protein 3

1

0

High-throughput

0.232

Low

1123508

BTG3
Protein BTG3

1

0

High-throughput

0.232

Low

1199909

PONL1
Podocan-like protein 1

1

0

High-throughput

0.232

Low

1199919

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

0

High-throughput

0.232

Low

1199926

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

0

High-throughput

0.232

Low

1199952

TB22B
TBC1 domain family member 22B

1

0

Small-scale

0.232

Low

1199956

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025