HitPredict

Interactor 1: BIN1 (O00499)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
Gene: BIN1

Interactor 2: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9182529
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 977
+	Rn
		88754 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		D3ZUY8_RAT (1-977): 0: 872: 95.30
+	Hs
		131185 BIN1_HUMAN (1-593): 1.03e-133: 404: 100.00		AP2A2_HUMAN (1-977): 0: 832: 76.97
+	Rn
		139993 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		Q66HM2_RAT (1-977): 0: 845: 79.39
+	Rn
		139988 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		AP2B1_RAT (34-972): 0: 676: 17.11
+	Hs
		321511 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		AP2A1_HUMAN (1-977): 0: 904: 100.00
+	Hs
		321552 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		AP2A1_HUMAN (1-977): 0: 904: 100.00
+	Rn
		88753 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		D3ZUY8_RAT (1-977): 0: 872: 95.30
+	Rn
		139980 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		Q66HM2_RAT (1-977): 0: 845: 79.39
+	Mm
		567528 AMPH_MOUSE (43-592): 1.88e-20: 97.6: 16.07		AP2A2_MOUSE (1-977): 0: 841: 79.29
+	Hs
		302118 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		AP2A2_HUMAN (1-977): 0: 832: 76.97
+	Hs
		302157 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		AP2A2_HUMAN (1-977): 0: 832: 76.97
+	Hs
		827733 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		AP2B1_HUMAN (34-972): 0: 676: 17.11
+	Mm
		1186720 AMPH_MOUSE (43-592): 1.88e-20: 97.6: 16.07		AP2B1_MOUSE (34-972): 0: 676: 17.01
+	Rn
		139975 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		AP2B1_RAT (34-972): 0: 676: 17.11
+	Hs
		827743 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		AP1B1_HUMAN (34-972): 0: 668: 18.15
+	Hs
		926031 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		AP2B1_HUMAN (34-972): 0: 676: 17.11
+	Hs
		925876 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		AP2B1_HUMAN (34-972): 0: 676: 17.11
+	Hs
		1014096 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		AP1B1_HUMAN (34-972): 0: 668: 18.15
+	Hs
		1014017 ITSN1_HUMAN (3-591): 1.85e-11: 69.4: 13.69		AP1B1_HUMAN (34-972): 0: 668: 18.15
+	Hs
		212606 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		AP1G1_HUMAN (1-864): 0: 612: 23.74