Protein: UCHL
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Ubiquitin thioesterase)

Gene: UCHL, Uch
Organism: Drosophila melanogaster
Interactions: 220
UniProt ID: P35122

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0030163 - protein catabolic process
GO:0045821 - positive regulation of glycolytic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

57525

A1ZB71
Glutathione S transferase E6

2

3

High-throughput

0.571

High

57748

A1ZB77
Uncharacterized protein, isoform J

2

3

High-throughput

0.571

High

578040

ENO
Enolase

2

4

High-throughput

0.571

High

609363

PCNA
Proliferating cell nuclear antigen

2

1

High-throughput

0.571

High

648860

ANXB9
Annexin B9

2

10

High-throughput

0.571

High

649007

ANX10
Annexin B10

2

10

High-throughput

0.571

High

682709

PROF
Profilin

2

2

High-throughput

0.571

High

762518

MOEH
Moesin/ezrin/radixin homolog 1

2

5

High-throughput

0.571

High

762519

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

2

7

High-throughput

0.571

High

762523

PDI
Protein disulfide-isomerase

2

8

High-throughput

0.571

High

762538

NLP
Nucleoplasmin-like protein

2

3

High-throughput

0.571

High

762554

TERA
Transitional endoplasmic reticulum ATPase TER94

2

6

High-throughput

0.571

High

762568

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

1

High-throughput

0.571

High

762572

NACA
Nascent polypeptide-associated complex subunit alpha

2

2

High-throughput

0.571

High

762594

Q9VAC4
GEO09167p1

2

3

High-throughput

0.571

High

762603

Q9VEB1
Malate dehydrogenase, mitochondrial

2

6

High-throughput

0.571

High

762638

Q9VPN5
Stress-induced-phosphoprotein 1

2

10

High-throughput

0.571

High

762639

Q9VPX6
Adenylyl cyclase-associated protein

2

2

High-throughput

0.571

High

762651

Q9VSL2
Glutathione S transferase O3

2

2

High-throughput

0.571

High

762675

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

3

High-throughput

0.571

High

762686

Q9XZ57
Eb1, isoform E

2

2

High-throughput

0.571

High

195004

O16043
Anon1A4

2

0

High-throughput

0.547

High

357470

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.547

High

762575

FAXC
Failed axon connections

2

0

High-throughput

0.547

High

762582

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

0

High-throughput

0.547

High

197734

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

2

1

High-throughput

0.521

High

459994

ALF
Fructose-bisphosphate aldolase

2

2

High-throughput

0.521

High

476909

NDKA
Nucleoside diphosphate kinase

2

2

High-throughput

0.521

High

712321

CALR
Calreticulin

2

2

High-throughput

0.521

High

762517

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

2

1

High-throughput

0.521

High

762529

PGK
Phosphoglycerate kinase

2

2

High-throughput

0.521

High

762545

Q7JX87
1-Cys peroxiredoxin

2

11

High-throughput

0.521

High

762585

Q9V3V2
peptidylprolyl isomerase

2

8

High-throughput

0.521

High

762587

THIO2
Thioredoxin-2

2

8

High-throughput

0.521

High

762608

Q9VGK3
peptidylprolyl isomerase

2

9

High-throughput

0.521

High

762613

Q9VHN7
transketolase

2

2

High-throughput

0.521

High

762622

Q9VK60
GH25425p

2

2

High-throughput

0.521

High

762626

EF1D
Probable elongation factor 1-delta

2

2

High-throughput

0.521

High

762627

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

2

4

High-throughput

0.521

High

762628

Q9VL70
HL08109p

2

3

High-throughput

0.521

High

762630

Q9VLB7
Rab GDP dissociation inhibitor

2

2

High-throughput

0.521

High

762653

Q9VTY2
Uncharacterized protein, isoform A

2

7

High-throughput

0.521

High

762660

Q9VVL7
Dihydrolipoyl dehydrogenase

2

2

High-throughput

0.521

High

762661

Q9VW59
Rho GDP-dissociation inhibitor 3

2

1

High-throughput

0.521

High

762687

PSA6
Proteasome subunit alpha type-6

2

20

High-throughput

0.521

High

762689

Q9Y112
BcDNA.GH10614

2

7

High-throughput

0.521

High

762637

Q9VNB2
RE42193p

1

0

High-throughput

0.481

High

94229

D5SHR3
HECT-type E3 ubiquitin transferase

1

4

High-throughput

0.481

High

263669

O61604
Fimbrin

1

11

High-throughput

0.479

High

762548

Q7K0B6
Glutathione S transferase T1

1

3

High-throughput

0.479

High

762558

Q86BM5
A kinase anchor protein 200, isoform D

1

2

High-throughput

0.479

High

762657

PYRG
CTP synthase

1

1

High-throughput

0.479

High

762565

Q8MSD1
LD05256p

1

0

High-throughput

0.458

High

762676

Q9W325
HECT-type E3 ubiquitin transferase

1

4

High-throughput

0.457

High

197307

O18335
Rab11

1

5

High-throughput

0.445

High

234544

VINC
Vinculin

1

2

High-throughput

0.445

High

262654

LOK
Ovarian-specific serine/threonine-protein kinase Lok

1

3

High-throughput

0.445

High

305635

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.445

High

556641

PSA1
Proteasome subunit alpha type-1

1

18

High-throughput

0.445

High

561766

MODU
DNA-binding protein modulo

1

3

High-throughput

0.445

High

611465

PSA4
Proteasome subunit alpha type-4

1

17

High-throughput

0.445

High

632939

GLNA1
Glutamine synthetase 1, mitochondrial

1

1

High-throughput

0.445

High

762525

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.445

High

762527

TRXR1
Thioredoxin reductase 1, mitochondrial

1

2

High-throughput

0.445

High

762533

Q0E993
Valine--tRNA ligase

1

3

High-throughput

0.445

High

762541

Q76NR6
Regucalcin

1

1

High-throughput

0.445

High

762544

Q7JVZ8
Glutathione S transferase E11, isoform A

1

3

High-throughput

0.445

High

762549

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.445

High

762561

Q8IQZ7
FI19014p1

1

11

High-throughput

0.445

High

762567

Q8MYY7
RE44624p

1

12

High-throughput

0.445

High

762569

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.445

High

762571

Q8T0L3
E1 ubiquitin-activating enzyme

1

3

High-throughput

0.445

High

762576

Q960M4
Peroxiredoxin-5

1

1

High-throughput

0.445

High

762577

IF5A
Eukaryotic translation initiation factor 5A

1

1

High-throughput

0.445

High

762580

Q9I7K7
Arrestin C-terminal-like domain-containing protein

1

1

High-throughput

0.445

High

762581

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.445

High

762591

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

9

High-throughput

0.445

High

762610

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.445

High

762618

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

1

High-throughput

0.445

High

762623

Q9VKB0
threonine--tRNA ligase

1

2

High-throughput

0.445

High

762625

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

5

High-throughput

0.445

High

762629

FKB59
FK506-binding protein 59

1

9

High-throughput

0.445

High

762631

AK200
A-kinase anchor protein 200

1

6

High-throughput

0.445

High

762632

SYAC
Alanine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.445

High

762643

Q9VQL1
serine--tRNA ligase

1

4

High-throughput

0.445

High

762645

Q9VRD6
NTF2-related export protein

1

3

High-throughput

0.445

High

762649

Q9VSC5
GM09977p

1

2

High-throughput

0.445

High

762656

Q9VUC1
Hsc70Cb, isoform A

1

9

High-throughput

0.445

High

762664

CLIC
Chloride intracellular channel Clic

1

4

High-throughput

0.445

High

762671

Q9W0H8
Reticulocalbin-3

1

6

High-throughput

0.445

High

762674

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.445

High

762678

Q9W3Y3
Calcyclin-binding protein

1

1

High-throughput

0.445

High

762681

Q9W457
Serine hydroxymethyltransferase

1

3

High-throughput

0.445

High

762683

NSUN2
tRNA

1

2

High-throughput

0.445

High

762685

Q9XYZ9
Glutathione S transferase E12, isoform A

1

3

High-throughput

0.445

High

52436

A1Z6X6
Lactoylglutathione lyase

1

1

High-throughput

0.437

High

120750

M9PE30
Transgelin

1

8

High-throughput

0.437

High

762563

Q8IRH7
Supercoiling factor variant B

1

6

High-throughput

0.437

High

762564

Q8IRS7
Ciboulot, isoform C

1

1

High-throughput

0.437

High

762609

Q9VGM2
Fatty acid-binding protein, muscle

1

3

High-throughput

0.437

High

762641

GOLP3
Golgi phosphoprotein 3 homolog sauron

1

1

High-throughput

0.437

High

762666

Q9VYR1
Regucalcin

1

1

High-throughput

0.437

High

762672

Q9W0M4
Endoplasmic reticulum transmembrane protein

1

1

High-throughput

0.437

High

121616

M9PFR6
Multiprotein bridging factor 1, isoform E

1

0

High-throughput

0.426

High

145951

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

356533

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.426

High

762556

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.426

High

762557

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.426

High

762583

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.426

High

762614

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

762634

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.426

High

762652

Q9VTX2
RE32936p

1

0

High-throughput

0.426

High

762658

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.426

High

762688

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.426

High

47748

A0AQH0
Proteasome subunit beta

1

20

High-throughput

0.407

High

53975

A1Z892
1-Cys peroxiredoxin

1

11

High-throughput

0.407

High

86458

B9EQV3
Endoplasmic reticulum transmembrane protein

1

1

High-throughput

0.407

High

121186

ALDR
Aldo-keto reductase 1B

1

7

High-throughput

0.407

High

234736

O46067
Hypoxia up-regulated protein 1

1

11

High-throughput

0.407

High

304597

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.407

High

357258

O97428
Ciboulot, isoform A

1

1

High-throughput

0.407

High

426633

HP1
Heterochromatin protein 1

1

5

High-throughput

0.407

High

458083

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.407

High

626987

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

652724

PSA71
Proteasome subunit alpha type-7-1

1

16

High-throughput

0.407

High

714669

TPIS
Triosephosphate isomerase

1

2

High-throughput

0.407

High

726309

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

762516

PSA2
Proteasome subunit alpha type-2

1

20

High-throughput

0.407

High

762530

HMGD
High mobility group protein D

1

5

High-throughput

0.407

High

762531

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.407

High

762537

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

5

High-throughput

0.407

High

762539

SAHH
Adenosylhomocysteinase

1

3

High-throughput

0.407

High

762540

Q3YMU0
Protein disulfide-isomerase

1

7

High-throughput

0.407

High

762542

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.407

High

762543

Q7JVH6
LD24696p

1

7

High-throughput

0.407

High

762546

Q7JXC4
CG6459 protein

1

1

High-throughput

0.407

High

762550

Q7K148
Proteasome subunit beta

1

20

High-throughput

0.407

High

762552

Q7K3J0
T-complex protein 1 subunit theta

1

9

High-throughput

0.407

High

762553

Q7KKI0
T-complex protein 1 subunit epsilon

1

9

High-throughput

0.407

High

762555

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.407

High

762560

Q8INK3
Fatty acid-binding protein, muscle

1

3

High-throughput

0.407

High

762574

PSA5
Proteasome subunit alpha type-5

1

14

High-throughput

0.407

High

762579

NASP
Nuclear autoantigenic sperm protein homolog

1

1

High-throughput

0.407

High

762584

Q9V3Q4
thioredoxin-dependent peroxiredoxin

1

11

High-throughput

0.407

High

762588

PDIA6
Protein disulfide-isomerase A6 homolog

1

8

High-throughput

0.407

High

762589

PSA3
Proteasome subunit alpha type-3

1

18

High-throughput

0.407

High

762592

Q9V9U3
LD45254p

1

2

High-throughput

0.407

High

762595

Q9VAG3
trypsin

1

1

High-throughput

0.407

High

762596

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.407

High

762597

Q9VAY2
Heat shock protein 83

1

7

High-throughput

0.407

High

762598

Q9VBR6
RE74917p

1

1

High-throughput

0.407

High

762601

Q9VD02
GH14779p

1

2

High-throughput

0.407

High

762602

Q9VD29
small monomeric GTPase

1

5

High-throughput

0.407

High

762604

FLNA
Filamin-A

1

9

High-throughput

0.407

High

762605

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.407

High

762606

Q9VG31
Malic enzyme

1

1

High-throughput

0.407

High

762611

TEBPH
Cytosolic Prostaglandin E synthase

1

2

High-throughput

0.407

High

762612

Q9VHL2
T-complex protein 1 subunit eta

1

10

High-throughput

0.407

High

762615

Q9VHX4
LD24679p

1

7

High-throughput

0.407

High

762619

Q9VJD4
LD24721p

1

10

High-throughput

0.407

High

762620

Q9VJJ0
Proteasome subunit beta

1

20

High-throughput

0.407

High

762621

Q9VJZ6
LD40224p

1

9

High-throughput

0.407

High

762624

Q9VKW5
Prolyl endopeptidase

1

3

High-throughput

0.407

High

762636

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.407

High

762640

Q9VQ61
Aspartate aminotransferase

1

1

High-throughput

0.407

High

762644

Q9VRD4
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

762647

Q9VRP2
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

762650

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

2

High-throughput

0.407

High

762654

Q9VU35
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.407

High

762655

WDR1
Actin-interacting protein 1

1

5

High-throughput

0.407

High

762659

CHMP5
Charged multivesicular body protein 5

1

2

High-throughput

0.407

High

762662

RS10B
Small ribosomal subunit protein eS10B

1

2

High-throughput

0.407

High

762667

TXND5
Thioredoxin domain-containing protein 5 homolog

1

9

High-throughput

0.407

High

762668

Q9VZI1
Transgelin

1

8

High-throughput

0.407

High

762670

Q9W022
GEO01508p1

1

9

High-throughput

0.407

High

762679

CISY
Probable citrate synthase, mitochondrial

1

2

High-throughput

0.407

High

762680

WUHO
tRNA

1

3

High-throughput

0.407

High

762684

PSB3
Proteasome subunit beta type-3

1

19

High-throughput

0.407

High

356301

O97102
Small ubiquitin-related modifier

2

0

High-throughput

0.298

High

762528

SODM
Superoxide dismutase [Mn], mitochondrial

2

0

High-throughput

0.298

High

762562

Q8IRD3
Glutathione peroxidase

2

0

High-throughput

0.298

High

762586

Q9V3V9
Endonuclease G inhibitor, isoform A

2

0

High-throughput

0.298

High

762547

SEELE
Protein seele

1

0

High-throughput

0.249

Low

53835

A1Z864
FI01421p

1

0

High-throughput

0.232

Low

305172

TRMB
tRNA

1

0

High-throughput

0.232

Low

614887

SYB
Synaptobrevin

1

0

High-throughput

0.232

Low

762520

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

762521

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.232

Low

762522

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.232

Low

762524

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

762526

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

762532

Q0E8X8
ATP synthase F1 subunit epsilon

1

0

High-throughput

0.232

Low

762534

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

762535

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

762536

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.232

Low

762551

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

762559

QPCT2
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.232

Low

762566

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.232

Low

762570

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.232

Low

762573

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

762578

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.232

Low

762590

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.232

Low

762593

Q9VAC1
GM14349p

1

0

High-throughput

0.232

Low

762599

ORN
Probable oligoribonuclease

1

0

High-throughput

0.232

Low

762600

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

762607

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

762616

Q9VIC3
carboxylesterase

1

0

High-throughput

0.232

Low

762617

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.232

Low

762633

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

762635

GUAD
Guanine deaminase

1

0

High-throughput

0.232

Low

762642

BACC
Bacchus

1

0

High-throughput

0.232

Low

762646

Q9VRL1
GEO06356p1

1

0

High-throughput

0.232

Low

762648

Q9VS98
LD12639p

1

0

High-throughput

0.232

Low

762663

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

762665

Q9VYB9
LP02557p

1

0

High-throughput

0.232

Low

762669

Q9VZY0
LD45195p

1

0

High-throughput

0.232

Low

762673

GALE
UDP-glucose 4-epimerase

1

0

High-throughput

0.232

Low

762677

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.232

Low

762682

Q9W478
RE43153p

1

0

High-throughput

0.232

Low

762690

DHRS7
Dehydrogenase/reductase SDR family protein 7-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025