HitPredict

Interactor 1: BIN1 (O00499)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
Gene: BIN1

Interactor 2: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.681

Property	Details
Experiments	16275660
Identification Methods	unspecified method, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 864
+	Mm
		139028 BIN1_MOUSE (1-592): 3.79e-129: 393: 94.10		DYN1_MOUSE (1-845): 0: 1081: 99.65
+	Rn
		139987 BIN1_RAT (1-592): 2.1e-127: 388: 93.59		DYN1_RAT (1-864): 0: 1081: 98.03
+	Hs
		131222 BIN1_HUMAN (1-593): 1.03e-133: 404: 100.00		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Mm
		139029 BIN1_MOUSE (1-592): 3.79e-129: 393: 94.10		DYN2_MOUSE (1-860): 0: 1022: 79.13
+	Mm
		139042 BIN1_MOUSE (1-592): 3.79e-129: 393: 94.10		DYN3_MOUSE (1-860): 0: 1012: 78.55
+	Hs
		983387 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Hs
		840692 SRC8_HUMAN (14-591): 1.39e-77: 257: 16.72		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Mm
		760473 SRC8_MOUSE (14-591): 3.51e-76: 253: 15.22		DYN2_MOUSE (1-860): 0: 1022: 79.13
+	Hs
		840739 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		1167839 DNMBP_HUMAN (17-591): 7.98e-54: 200: 16.93		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Hs
		827736 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Mm
		760459 AMPH_MOUSE (43-592): 1.88e-20: 97.6: 16.07		DYN1_MOUSE (1-845): 0: 1081: 99.65
+	Rn
		139973 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		DYN1_RAT (1-864): 0: 1081: 98.03
+	Hs
		827729 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Mm
		760477 AMPH_MOUSE (43-592): 1.88e-20: 97.6: 16.07		DYN2_MOUSE (1-860): 0: 1022: 79.13
+	Rn
		139974 AMPH_RAT (44-592): 1.56e-19: 94.9: 16.52		DYN2_RAT (1-860): 0: 1021: 79.02
+	Mm
		1186718 AMPH_MOUSE (43-592): 1.88e-20: 97.6: 16.07		DYN3_MOUSE (1-860): 0: 1012: 78.55
+	Hs
		827766 AMPH_HUMAN (44-592): 1.49e-21: 101: 15.13		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Dm
		112570 M9ND00_DROME (322-591): 2.06e-32: 135: 16.49		DYN_DROME (6-859): 0: 963: 65.41
+	Hs
		840840 ITSN2_HUMAN (2-593): 2.37e-12: 72.5: 11.45		DYN2_HUMAN (1-860): 0: 1021: 78.91